Ionamin

Caloric Restriction, Obesity, Type 2 Diabetes + 6 more
Treatment
3 FDA approvals
20 Active Studies for Ionamin

What is Ionamin

PhentermineThe Generic name of this drug
Treatment SummaryPhentermine is an anti-obesity drug that works by suppressing the appetite. It was introduced in 1959 and approved by the FDA for short-term weight management. Phentermine was originally offered as a combination drug with fenfluramine and dexfenfluramine, but this was discontinued due to reports of abnormal valves in 30% of consumers. In 2012, phentermine was approved for use alone or in combination with topiramate. It has a low risk of addiction and is classified as Schedule IV drug.
Ionaminis the brand name
image of different drug pills on a surface
Ionamin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ionamin
Phentermine
1959
298

Approved as Treatment by the FDA

Phentermine, also known as Ionamin, is approved by the FDA for 3 uses including Obesity and Comorbidity .
Obesity
Used to treat Obesity in combination with Topiramate
Comorbidity
Used to treat one related comorbidity in combination with Topiramate
Regime of weight reduction

Effectiveness

How Ionamin Affects PatientsPhentermine works by suppressing appetite, possibly due to an increase in leptin. It also may increase the amount of energy used when resting. In clinical studies, patients taking phentermine lost an average of 3.6 kg in 2-24 weeks compared to those taking a placebo. Additionally, these patients were able to keep their weight off even after stopping taking the drug. Phentermine is a derivative of the amphetamines, but does not cause any of the amphetamine-related side effects, such as stimulation of the central nervous system, increased blood pressure, or changes in heart rate.
How Ionamin works in the bodyPhentermine works by releasing a special chemical called noradrenaline in the brain. This chemical increases the activity of certain receptors, making them more sensitive to energy signals. It also suppresses the hunger signal by reducing the activity of another chemical called neuropeptide Y. Lastly, it has a weak effect on monoamine oxidase, which is a chemical in the brain responsible for breaking down certain chemicals. All of these effects work together to make us feel less hungry and more energized.

When to interrupt dosage

The indicated dosage of Ionamin relies upon the diagnosed circumstances, such as Regime of weight reduction, Hyperlipidemia and Type 2 Diabetes. The measure of dosage additionally fluctuates in accordance with the method of delivery (e.g. Oral or Tablet) featured in the table underneath.
Condition
Dosage
Administration
Caloric Restriction
, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Type 2 Diabetes
, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Obesity
, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Hypertensive disease
, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
High Cholesterol
, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Regime of weight reduction
, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Chronic Weight Management therapy
, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
increase in physical activity
, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Comorbidity
, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral

Warnings

Ionamin Contraindications
Condition
Risk Level
Notes
Hyperthyroidism
Do Not Combine
concomitant use or 14 days after discontinuation
Do Not Combine
Agitation
Do Not Combine
Drug abuse
Do Not Combine
Cardiovascular Diseases
Do Not Combine
Open-angle glaucoma
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Phentermine may interact with Pulse Frequency
There are 20 known major drug interactions with Ionamin.
Common Ionamin Drug Interactions
Drug Name
Risk Level
Description
Iobenguane
Major
Phentermine can cause a decrease in the absorption of Iobenguane resulting in a reduced serum concentration and potentially a decrease in efficacy.
Methylene blue
Major
Phentermine may increase the serotonergic activities of Methylene blue.
Mirtazapine
Major
Phentermine may increase the serotonergic activities of Mirtazapine.
1-benzylimidazole
Minor
The therapeutic efficacy of 1-benzylimidazole can be decreased when used in combination with Phentermine.
4-Methoxyamphetamine
Minor
The risk or severity of hypertension can be increased when Phentermine is combined with 4-Methoxyamphetamine.
Ionamin Toxicity & Overdose RiskThe highest dose of phentermine that has been found to be toxic in rats is 151 mg/kg. Signs of acute overdose can range from restlessness, tremors, and confusion to fatigue and depression. It can also affect the cardiovascular system, causing rapid heartbeat, abnormal heart rhythms, high or low blood pressure, or circulation collapse. There may also be gastrointestinal symptoms such as nausea, vomiting, diarrhea, or abdominal cramps. Treatment for overdose includes symptom relief, lavage, and sedation with barbiturates. Chronic overdosage may result in skin problems, insomnia, irritability, and changes in personality or behavior.

Ionamin Novel Uses: Which Conditions Have a Clinical Trial Featuring Ionamin?

104 active clinical trials are presently being conducted to assess the efficacy of Ionamin in providing a therapeutic management of Type 2 Diabetes, Weight Reduction Regimens and Diseases.
Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
90 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Obesity
0 Actively Recruiting
Hypertensive disease
0 Actively Recruiting
Comorbidity
0 Actively Recruiting
High Cholesterol
14 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Early Phase 1
Caloric Restriction
0 Actively Recruiting
Regime of weight reduction
0 Actively Recruiting
increase in physical activity
0 Actively Recruiting
Chronic Weight Management therapy
0 Actively Recruiting

Ionamin Reviews: What are patients saying about Ionamin?

5Patient Review
7/31/2013
Ionamin for Overweight
I've been taking this medication for a while now, and it's really great. I'm a bit heavier than I was in high school, but that's not necessarily a bad thing. My doctor monitors my bloodwork every six months and I haven't had any adverse effects.
5Patient Review
3/28/2010
Ionamin for Overweight
Phentermine has helped me lose 18 pounds in just three months, and I'm hoping to lose 20 more pounds with this round of treatment. I've also noticed that my sweating has increased when working out, which means that my body is burning fat more efficiently. This drug is really effective!
5Patient Review
1/12/2008
Ionamin for Overweight
3.7Patient Review
9/23/2010
Ionamin for Overweight
I had tried to lose weight through diet and exercise after my second baby, but saw no results. A doctor then prescribed this pill to me, and I dropped 30 pounds in three months. I have now been off the pill for five months and have not gained any weight back, which is amazing.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about ionamin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Ionamin still on the market?

"Ionamin is no longer available in the United States. If the FDA has approved generic versions of this product, there may be generic equivalents available."

Answered by AI

What kind of drug is Ionamin?

"Ionamin is a stimulant that is used in combination with diet and exercise to treat obesity in people who have risk factors such as high blood pressure, high cholesterol, or diabetes."

Answered by AI

Is phentermine effective for weight loss?

"Phentermine is effective for weight loss, with people typically losing 3% of their initial body weight after 3 months and 5-7% after 6 months. Some people report even more weight loss than this."

Answered by AI

Do you need a prescription for Ionamin?

"Ionamin is a prescription medicine used to treat obesity. It may be used alone or with other medications. Ionamin belongs to a class of drugs called CNS Stimulants, which includes Anorexiants and Stimulants. Sympathomimetic drugs act on the sympathetic nervous system."

Answered by AI

Clinical Trials for Ionamin

Have you considered Ionamin clinical trials? We made a collection of clinical trials featuring Ionamin, we think they might fit your search criteria.
Have you considered Ionamin clinical trials? We made a collection of clinical trials featuring Ionamin, we think they might fit your search criteria.
Have you considered Ionamin clinical trials? We made a collection of clinical trials featuring Ionamin, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top