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What is Kazano
AlogliptinThe Generic name of this drug
Treatment SummaryAlogliptin is an oral medication used to block the activity of an enzyme called dipeptidyl peptidase-4 (DPP-4). It is available as a salt and is mostly made up of the R-enantiomer form. Alogliptin was approved by the FDA in 2013.
Nesinais the brand name
Kazano Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Nesina
Alogliptin
2013
26
Approved as Treatment by the FDA
Alogliptin, also known as Nesina, is approved by the FDA for 3 uses which include Type 2 Diabetes and Diet .Type 2 Diabetes
Used to treat Type 2 Diabetes Mellitus in combination with Pioglitazone
Diet
Used to treat Diet in combination with Pioglitazone
Physical Activity
Used to treat Exercise in combination with Pioglitazone
Effectiveness
How Kazano Affects PatientsAlogliptin is effective within 2-3 hours of taking a single dose, and can keep working for up to 24 hours if taken in a dose of 25 mg or higher. It reduces the amount of glucagon produced after eating, and increases the amount of active GLP-1 in the body. Alogliptin does not have any effect on the heart's electrical activity.
How Kazano works in the bodyAlogliptin helps control blood sugar levels by blocking an enzyme that breaks down two hormones that regulate blood sugar. These hormones, called incretins, stimulate the pancreas to produce insulin and suppress the production of glucagon. They also make you feel full and reduce the amount of food you eat. Blocking the enzyme that breaks them down allows more of these hormones to remain active, helping to control your blood sugar.
When to interrupt dosage
The prescribed dosage of Kazano is contingent upon the specified condition, including Diet, Physical Activity and Type 2 Diabetes. The magnitude of dosage is based on the technique of administration indicated in the table below.Condition
Dosage
Administration
Diet
, 6.25 mg, 12.5 mg, 25.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Type 2 Diabetes
, 6.25 mg, 12.5 mg, 25.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Physical Activity
, 6.25 mg, 12.5 mg, 25.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Warnings
There are 20 known major drug interactions with Kazano.Common Kazano Drug Interactions
Drug Name
Risk Level
Description
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Alogliptin.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Alogliptin.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Alogliptin.
Clomipramine
Major
The metabolism of Clomipramine can be decreased when combined with Alogliptin.
Clonidine
Major
The metabolism of Clonidine can be decreased when combined with Alogliptin.
Kazano Toxicity & Overdose RiskCommon side effects of alogliptin include a stuffy or runny nose, headaches, and a cold or other upper respiratory infection.
Kazano Novel Uses: Which Conditions Have a Clinical Trial Featuring Kazano?
196 active clinical trials are investigating the utility of Kazano in augmenting Physical Activity, ameliorating Type 2 Diabetes and optimizing Diet.Condition
Clinical Trials
Trial Phases
Diet
5 Actively Recruiting
Not Applicable
Physical Activity
39 Actively Recruiting
Not Applicable, Phase 2, Phase 1, Early Phase 1
Type 2 Diabetes
192 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3
Kazano Reviews: What are patients saying about Kazano?
5Patient Review
4/6/2021 I don't know why, but metformin alone makes my stomach unbearably upset. With Kazano my blood sugar levels are great and I have no GI issues.
3.7Patient Review
9/5/20133.7Patient Review
12/19/20133.3Patient Review
5/18/2016 For the past two years, this medication has been great for keeping my A1c levels down. However, I've recently noticed that my blood sugar is always high, especially in the morning. Nothing else in my routine has changed, so I think it might be time to switch medications.
3.3Patient Review
2/28/2014 I was really sweating a lot, my eyes were watery, and I had a runny nose.
3Patient Review
9/29/2014 Unfortunately, I experienced some pretty intense diarrhea. This also came with nausea and a loss of appetite.
Patient Q&A Section about kazano
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of Kazano?
"An upper respiratory tract infection can cause symptoms like a stuffy nose, sinus pain, and a sore throat. Other possible causes of these symptoms include a cold, a headache, back pain, a urinary tract infection, high blood pressure, and diarrhea."
Answered by AI
What is Kazano used for?
"Kazano is a combination medication containing alogliptin and metformin. This medication is designed to be used in conjunction with diet and exercise to improve blood sugar control in people with type 2 diabetes."
Answered by AI
How much does Kazano cost?
"The price of Kazano oral tablets (12.5 mg-500 mg) varies depending on the pharmacy, but is around $440 for a supply of 60 tablets. This price is for cash paying customers only and does not apply to customers with insurance plans."
Answered by AI
What are Gliflozin drugs?
"This class of drugs is used to lower high blood glucose levels in people with type 2 diabetes by inhibiting the SGLT-2 proteins located in the renal tubules of the kidneys, which are responsible for reabsorbing glucose back into the blood."
Answered by AI