Avandia

Physical Activity, Type 2 Diabetes, Diet

Treatment

20 Active Studies for Avandia

Treatment for

Physical Activity

What is Avandia

RosiglitazoneThe Generic name of this drug

Treatment SummaryRosiglitazone is a medication used to treat diabetes. It works by activating a protein in the body called PPARγ, which helps the body respond better to insulin. Rosiglitazone is sold under the brand names Avandia, Avandamet, and Avandaryl. It may also help reduce inflammation, and research suggests that it could potentially be used to help people with Alzheimer's disease who do not have the ApoE4 gene.

Avandiais the brand name

image of different drug pills on a surface

Avandia Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Avandia

Rosiglitazone

1999

Effectiveness

How Avandia Affects PatientsTaking rosiglitazone on its own can lead to increases in total cholesterol, LDL (bad cholesterol), and HDL (good cholesterol). It also leads to lower levels of free fatty acids. LDL levels tend to peak at 1 to 2 months of taking the drug and remain elevated beyond that, but HDL levels will continue to rise. The LDL/HDL ratio will be highest after 2 months and then should start to decrease over time.

How Avandia works in the bodyRosiglitazone helps the body respond better to insulin, by activating special receptors in tissues like fat, muscle, and the liver. This helps control how glucose is made, moved, and used up in the body.

When to interrupt dosage

The dosage of Avandia is contingent upon the determined condition, including Diet, Physical Activity and Type 2 Diabetes. The measure of dosage will depend on the delivery technique (e.g. Tablet - Oral or Oral) listed in the table underneath.

Condition

Dosage

Administration

Diet

, 2.0 mg, 8.0 mg, 4.0 mg, 1.0 mg

, Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral

Type 2 Diabetes

, 2.0 mg, 8.0 mg, 4.0 mg, 1.0 mg

, Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral

Physical Activity

, 2.0 mg, 8.0 mg, 4.0 mg, 1.0 mg

, Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral

Warnings

Avandia has three contraindications, so its use should be avoided when encountering any of the conditions given in the following table.Avandia Contraindications

Condition

Risk Level

Notes

Hypesthesia

Do Not Combine

Hypesthesia

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Rosiglitazone may interact with Pulse Frequency

There are 20 known major drug interactions with Avandia.

Common Avandia Drug Interactions

Drug Name

Risk Level

Description

Aminophylline

Major

The metabolism of Aminophylline can be decreased when combined with Rosiglitazone.

Brigatinib

Major

The metabolism of Brigatinib can be decreased when combined with Rosiglitazone.

Cabazitaxel

Major

The metabolism of Cabazitaxel can be decreased when combined with Rosiglitazone.

Enasidenib

Major

The metabolism of Enasidenib can be decreased when combined with Rosiglitazone.

Erlotinib

Major

The metabolism of Erlotinib can be decreased when combined with Rosiglitazone.

Avandia Toxicity & Overdose RiskSide effects of the drug include an accumulation of fluids, CHF, and liver damage.

image of a doctor in a lab doing drug, clinical research

Avandia Novel Uses: Which Conditions Have a Clinical Trial Featuring Avandia?

196 active investigations are assessing the potency of Avandia in providing relief for Type 2 Diabetes, Physical Activity and Diet related issues.

Condition

Clinical Trials

Trial Phases

Type 2 Diabetes

179 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1

Diet

5 Actively Recruiting

Not Applicable, Phase 1

Physical Activity

35 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Early Phase 1