Avandia

Physical Activity, Type 2 Diabetes, Diet
Treatment
20 Active Studies for Avandia

What is Avandia

RosiglitazoneThe Generic name of this drug
Treatment SummaryRosiglitazone is a medication used to treat diabetes. It works by activating a protein in the body called PPARγ, which helps the body respond better to insulin. Rosiglitazone is sold under the brand names Avandia, Avandamet, and Avandaryl. It may also help reduce inflammation, and research suggests that it could potentially be used to help people with Alzheimer's disease who do not have the ApoE4 gene.
Avandiais the brand name
image of different drug pills on a surface
Avandia Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Avandia
Rosiglitazone
1999
51

Effectiveness

How Avandia Affects PatientsTaking rosiglitazone on its own can lead to increases in total cholesterol, LDL (bad cholesterol), and HDL (good cholesterol). It also leads to lower levels of free fatty acids. LDL levels tend to peak at 1 to 2 months of taking the drug and remain elevated beyond that, but HDL levels will continue to rise. The LDL/HDL ratio will be highest after 2 months and then should start to decrease over time.
How Avandia works in the bodyRosiglitazone helps the body respond better to insulin, by activating special receptors in tissues like fat, muscle, and the liver. This helps control how glucose is made, moved, and used up in the body.

When to interrupt dosage

The dosage of Avandia is contingent upon the determined condition, including Diet, Physical Activity and Type 2 Diabetes. The measure of dosage will depend on the delivery technique (e.g. Tablet - Oral or Oral) listed in the table underneath.
Condition
Dosage
Administration
Type 2 Diabetes
, 2.0 mg, 8.0 mg, 4.0 mg, 1.0 mg
, Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral
Diet
, 2.0 mg, 8.0 mg, 4.0 mg, 1.0 mg
, Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral
Physical Activity
, 2.0 mg, 8.0 mg, 4.0 mg, 1.0 mg
, Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral

Warnings

Avandia has three contraindications, so its use should be avoided when encountering any of the conditions given in the following table.Avandia Contraindications
Condition
Risk Level
Notes
Hypesthesia
Do Not Combine
Hypesthesia
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Rosiglitazone may interact with Pulse Frequency
There are 20 known major drug interactions with Avandia.
Common Avandia Drug Interactions
Drug Name
Risk Level
Description
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Rosiglitazone.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Rosiglitazone.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Rosiglitazone.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Rosiglitazone.
Erlotinib
Major
The metabolism of Erlotinib can be decreased when combined with Rosiglitazone.
Avandia Toxicity & Overdose RiskSide effects of the drug include an accumulation of fluids, CHF, and liver damage.
image of a doctor in a lab doing drug, clinical research

Avandia Novel Uses: Which Conditions Have a Clinical Trial Featuring Avandia?

196 active investigations are assessing the potency of Avandia in providing relief for Type 2 Diabetes, Physical Activity and Diet related issues.
Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
170 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Diet
5 Actively Recruiting
Not Applicable, Phase 1
Physical Activity
24 Actively Recruiting
Not Applicable, Phase 1, Phase 2

Avandia Reviews: What are patients saying about Avandia?

5Patient Review
6/16/2011
Avandia for Type 2 Diabetes Mellitus
Diabetes is a lifestyle disease that cannot be fixed by drugs. If you want to heal, you need to change your lifestyle and the food you consume.
5Patient Review
7/26/2010
Avandia for Type 2 Diabetes Mellitus
I took this medication for 10 months. While it did lower my blood sugar, the side effects were really bad. I gained 15 kgs, couldn't breathe well, and had swollen legs and hands. I wouldn't recommend this to anyone.
5Patient Review
11/14/2011
Avandia for Type 2 Diabetes Mellitus
So far, I'm really enjoying this new medication!
5Patient Review
4/19/2016
Avandia for Type 2 Diabetes Mellitus
I was prescribed Avandia to treat my diabetes II after experiencing congestive heart failure in 2003. I saw a cardiologist and diabetes specialist regularly while taking it, and never experienced any side effects. My blood sugar was effectively controlled with Metformin and Glyburide without insulin, to an A1C of 6.8.
4.3Patient Review
9/24/2010
Avandia for Type 2 Diabetes Mellitus
I unfortunately experienced some negative cardiovascular effects after taking this medication.
4Patient Review
3/26/2011
Avandia for Type 2 Diabetes Mellitus
Unfortunately, after taking Avandia for five months I developed cirrhosis of the liver. I am now awaiting a transplant. Additionally, while on this medication I gained 50-60 pounds and constantly had excess fluid all over my body. Consequently, I have joined a lawsuit against Glaxo Smith Kline.
4Patient Review
7/19/2010
Avandia for Type 2 Diabetes Mellitus
My husband's heart failure has been greatly assisted by this drug.
3.7Patient Review
8/11/2011
Avandia for Type 2 Diabetes Mellitus
This treatment has been effective in keeping my glucose levels normal for the past 5 years.
3.7Patient Review
7/14/2010
Avandia for Type 2 Diabetes Mellitus
3.3Patient Review
6/24/2010
Avandia for Type 2 Diabetes Mellitus
2.7Patient Review
7/13/2010
Avandia for Type 2 Diabetes Mellitus
2.7Patient Review
7/15/2010
Avandia for Type 2 Diabetes Mellitus
2.7Patient Review
7/16/2010
Avandia for Type 2 Diabetes Mellitus
2.7Patient Review
10/14/2010
Avandia for Type 2 Diabetes Mellitus
I've been taking this medication for four years now with no issues. It's effective for me.
2.7Patient Review
12/15/2010
Avandia for Type 2 Diabetes Mellitus
I stopped taking Avandia when reports came out, and I felt much better - even lost 10lbs. However, my A1C went up to 7.6. My doctor made me go back on in May, and now I've gained the weight back and feel tired and achy all the time. I'm waiting to see the doctor in September so that I can get off of this medication for good!
2Patient Review
7/19/2010
Avandia for Type 2 Diabetes Mellitus
I was on this medication for six years and it did help with my edema, but I have seen other comments from people over 50 who had similar experiences. My weight gain is due to overeating and now I'm having more heart palpitations and my blood pressure has gone dangerously high. This is something that runs in my family so I know it's not the medication. I will miss one thing about it though; I wasn't allergic to it like some of the other medications I've tried.
1.7Patient Review
8/12/2010
Avandia for Type 2 Diabetes Mellitus
I was on this a while ago but my doctor took me off of it because of the dangers associated with the drug. My new doctor put me back on it, and in just one month I've gained 10 pounds, feel constantly fatigued, have swollen joints, and overall feel terrible. This medication hasn't lowered my blood sugar levels at all, so I'm going to stop taking it. With my high blood pressure and heart rate, I don't think this is a good medication for me.
1.3Patient Review
1/2/2012
Avandia for Type 2 Diabetes Mellitus
I have developed serious heart problems as a result of taking this drug. I have had stents installed, a pacemaker, and multiple heart attacks. This medication has shortened my life span and I would not recommend it to anyone.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about avandia

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the drug Avandia used for?

"Rosiglitazone is used in combination with a diet and exercise regimen to help control blood sugar levels in people with type 2 diabetes. Maintaining normal blood sugar levels can help prevent complications such as kidney damage, blindness, nerve problems, limb loss, and sexual dysfunction."

Answered by AI

What are the side effects of Avandia?

"The most common side effects of Avandia (rosiglitazone) are upper respiratory tract infection, headache, back pain, high blood sugar, fatigue, sinusitis, diarrhea and low blood sugar. However, there are also some serious potential side effects, such as heart failure, heart attack, liver damage and bone fracture."

Answered by AI

Who should not take Avandia?

"AVANDIA should not be taken by people with type 1 diabetes mellitus or those who are in diabetic ketoacidosis. Additionally,AVANDIA should not be taken with insulin."

Answered by AI

Is Avandia same as metformin?

"Avandia contains the active drug rosiglitazone, which belongs to a class of medications called thiazolidinediones. Metformin is the generic version of a drug Glucophage. Metformin belongs to a class of drugs called biguanides."

Answered by AI

Clinical Trials for Avandia

Image of NYU Langone Health in New York, United States.

Adaptive Dietary Intervention for Type 2 Diabetes

18+
All Sexes
New York, NY
The investigators will examine the feasibility, acceptability, and effect of an adaptive dietary intervention over 24 weeks (12-week intervention, 12-week follow-up) among Asian Americans with Type 2 diabetes. Participants (N=120; 60 Chinese Americans and 60 Vietnamese Americans) will be 2:1 randomized to one of two arms: adaptive dietary intervention or standard of care (SC). The intervention will begin with continued glucose monitoring (CGM) use only during weeks 0-4. At week 4, participants who achieve the glycemic control goal (at least an 8% increase in time in range \[TIR\] from baseline) will continue with the CGM alone during weeks 4-12 ("CGM Alone"); otherwise, culturally and linguistically adapted glucose excursion minimization (GEM) will be augmented with CGM ("CGM-GEM").
Waitlist Available
Has No Placebo
NYU Langone HealthYaguang Zheng, PhD, RN
Image of KPNC Division of Research in Pleasanton, United States.

MetSense Risk Flag for Type 2 Diabetes

18+
All Sexes
Pleasanton, CA
People with serious mental illness have high risk for type 2 diabetes due to multiple risk factors, including the metabolic side effects of psychotropic medications that are used to treat these conditions. Type 2 diabetes is preventable through lifestyle and pharmacological interventions, but many people with serious mental illness do not receive regular screening for type 2 diabetes risk. In many health care settings, clinical pharmacists are increasingly managing patients with serious mental illness and have expertise in monitoring the metabolic side effects of psychotropic medications. This study evaluates the feasibility and acceptability of using a diabetes prediction model that is based on electronic health record data (the MetSense risk flag) to alert clinical pharmacists about patients who are at high diabetes risk, prompting these clinicians to prioritize diabetes risk management services.
Waitlist Available
Has No Placebo
KPNC Division of ResearchEsti Iturralde, PhD
Have you considered Avandia clinical trials? We made a collection of clinical trials featuring Avandia, we think they might fit your search criteria.Go to Trials
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PATAS for Type 2 Diabetes

18 - 55
All Sexes
Cincinnati, OH
The primary objective of Part 1 of this study is to evaluate safety and tolerability of single subcutaneous (SC) doses of PATAS in healthy subjects. The secondary objective of Part 1 of this study is to determine the pharmacokinetics (PK) of single SC doses of PATAS in healthy subjects. The primary objectives of Part 2 of this study are to evaluate the safety and tolerability of 4 weekly SC doses of PATAS in subjects with T2D; and to determine the PK and pharmacodynamics (PD) of 4 weekly SC doses of PATAS in subjects with T2D. The secondary objectives of Part 2 of this study are to evaluate the potential effect of multiple SC doses of PATAS on markers of glycemic control, as measured by glucose levels, insulin levels, and other metabolomic biomarkers; and to characterize the adverse event (AE) profiles of the various dose levels of PATAS.
Phase 1
Waitlist Available
Medpace Clinical Pharmaology UnitVincent Marion, Ph.D.AdipoPharma LLC
Image of The Worship Center Cristian Church in Birmingham, United States.

Black Impact for Heart Health

18+
Male
Birmingham, AL
The goal of this clinical trial is to evaluate the implementation and effectiveness of the Black Impact program-a church-based cardiovascular health (CVH) intervention-in Black men aged 35-70 who are at risk for heart disease, diabetes, obesity, and related conditions. The main questions this study aims to answer are: * Does participation in the Black Impact program improve cardiovascular health metrics (e.g., blood pressure, cholesterol, blood sugar) and health behaviors among Black men at The Worship Center Christian Church (TWC)? * What factors influence the adoption, delivery, and sustainability of the Black Impact program in a faith-based setting? Researchers will compare an immediate-start intervention group and a delayed-start (waitlist control) group to assess both short-term health outcomes and program implementation factors. Participants will: * Attend a 90-minute weekly session for 24 weeks, including 45 minutes of physical activity led by a certified trainer and 45 minutes of health education delivered by trained coaches. * Receive one-on-one support from a community health worker to reduce barriers to care and engage with primary care. * Complete biometric health screenings and surveys at baseline, 12 weeks, and 24 weeks to assess clinical and behavioral outcomes. * Use a smartwatch, blood pressure cuff, and other tools to track progress in real time. * Participate in exit focus groups or interviews to share feedback about the intervention. * A subset of TWC leaders and interventionists (N=15) will also be interviewed to assess implementation, resource needs, and sustainability. This study uses the RE-AIM framework to assess Reach, Effectiveness, Adoption, Implementation, and Maintenance, and aims to inform scalable strategies for improving CVH among Black men in trusted community settings.
Waitlist Available
Has No Placebo
The Worship Center Cristian Church
Have you considered Avandia clinical trials? We made a collection of clinical trials featuring Avandia, we think they might fit your search criteria.Go to Trials
Image of University of British Columbia - Okanagan in Kelowna, Canada.

Estrogen and Testosterone for Gender Differences in Physiology

18 - 40
All Sexes
Kelowna, Canada
Due to historical exclusion of females from research, there are gaps in the understanding of female physiology, how it differs from males, and how sex-specific hormones contribute. As a result, many diagnoses and treatments are based on male physiology and may not be appropriate or effective for females. Females consistently experience greater risk and report worse neurological outcomes in many diseases, including stroke, cardiac arrest, and dementia. As research in females progresses, differences between sexes and changes throughout the lifespan (e.g., puberty, menopause) highlight the importance of understanding the effects of sex and sex-specific hormones on the body. The brain is arguably the most important organ in the body, consuming 20% of the body's total energy. Previous research supports higher blood flow to the brain in females, and research in animals suggests hormones such as estrogen, progesterone, and testosterone are responsible. However, it is extremely difficult to isolate these hormones in humans, due to natural fluctuations (i.e., menstrual cycle). Therefore, the investigators plan to explore the direct role of these sex-specific hormones in regulating blood flow to the brain by blocking hormone production in healthy males and females and giving back testosterone and estrogen, respectively. The investigators will then conduct a range of tests to look at blood flow to the brain at rest and during various stressors. This research will provide crucial insight into how males and females differ in regulation of brain blood flow and inform new treatments and therapies to a wide range of brain injuries and diseases, improving outcomes and reducing the sex disparity in clinical pathways.
Waitlist Available
Has No Placebo
University of British Columbia - OkanaganPhilip Ainslie, PhD
Have you considered Avandia clinical trials? We made a collection of clinical trials featuring Avandia, we think they might fit your search criteria.Go to Trials