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What is Avandia
RosiglitazoneThe Generic name of this drug
Treatment SummaryRosiglitazone is a medication used to treat diabetes. It works by activating a protein in the body called PPARγ, which helps the body respond better to insulin. Rosiglitazone is sold under the brand names Avandia, Avandamet, and Avandaryl. It may also help reduce inflammation, and research suggests that it could potentially be used to help people with Alzheimer's disease who do not have the ApoE4 gene.
Avandiais the brand name
Avandia Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Avandia
Rosiglitazone
1999
51
Effectiveness
How Avandia Affects PatientsTaking rosiglitazone on its own can lead to increases in total cholesterol, LDL (bad cholesterol), and HDL (good cholesterol). It also leads to lower levels of free fatty acids. LDL levels tend to peak at 1 to 2 months of taking the drug and remain elevated beyond that, but HDL levels will continue to rise. The LDL/HDL ratio will be highest after 2 months and then should start to decrease over time.
How Avandia works in the bodyRosiglitazone helps the body respond better to insulin, by activating special receptors in tissues like fat, muscle, and the liver. This helps control how glucose is made, moved, and used up in the body.
When to interrupt dosage
The dosage of Avandia is contingent upon the determined condition, including Diet, Physical Activity and Type 2 Diabetes. The measure of dosage will depend on the delivery technique (e.g. Tablet - Oral or Oral) listed in the table underneath.Condition
Dosage
Administration
Diet
, 2.0 mg, 8.0 mg, 4.0 mg, 1.0 mg
, Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral
Type 2 Diabetes
, 2.0 mg, 8.0 mg, 4.0 mg, 1.0 mg
, Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral
Physical Activity
, 2.0 mg, 8.0 mg, 4.0 mg, 1.0 mg
, Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral
Warnings
Avandia has three contraindications, so its use should be avoided when encountering any of the conditions given in the following table.Avandia ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Rosiglitazone may interact with Pulse Frequency
Hypesthesia
Do Not Combine
Hypesthesia
Do Not Combine
Common Avandia Drug Interactions
Drug Name
Risk Level
Description
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Rosiglitazone.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Rosiglitazone.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Rosiglitazone.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Rosiglitazone.
Erlotinib
Major
The metabolism of Erlotinib can be decreased when combined with Rosiglitazone.
Avandia Toxicity & Overdose RiskSide effects of the drug include an accumulation of fluids, CHF, and liver damage.
Avandia Novel Uses: Which Conditions Have a Clinical Trial Featuring Avandia?
196 active investigations are assessing the potency of Avandia in providing relief for Type 2 Diabetes, Physical Activity and Diet related issues.Condition
Clinical Trials
Trial Phases
Physical Activity
39 Actively Recruiting
Not Applicable, Phase 2, Phase 1, Early Phase 1
Type 2 Diabetes
192 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3
Diet
5 Actively Recruiting
Not Applicable
Avandia Reviews: What are patients saying about Avandia?
5Patient Review
6/16/2011 Diabetes is a lifestyle disease that cannot be fixed by drugs. If you want to heal, you need to change your lifestyle and the food you consume.
5Patient Review
7/26/2010 I took this medication for 10 months. While it did lower my blood sugar, the side effects were really bad. I gained 15 kgs, couldn't breathe well, and had swollen legs and hands. I wouldn't recommend this to anyone.
5Patient Review
11/14/2011 So far, I'm really enjoying this new medication!
5Patient Review
4/19/2016 I was prescribed Avandia to treat my diabetes II after experiencing congestive heart failure in 2003. I saw a cardiologist and diabetes specialist regularly while taking it, and never experienced any side effects. My blood sugar was effectively controlled with Metformin and Glyburide without insulin, to an A1C of 6.8.
4.3Patient Review
9/24/2010 I unfortunately experienced some negative cardiovascular effects after taking this medication.
4Patient Review
3/26/2011 Unfortunately, after taking Avandia for five months I developed cirrhosis of the liver. I am now awaiting a transplant. Additionally, while on this medication I gained 50-60 pounds and constantly had excess fluid all over my body. Consequently, I have joined a lawsuit against Glaxo Smith Kline.
4Patient Review
7/19/2010 My husband's heart failure has been greatly assisted by this drug.
3.7Patient Review
8/11/2011 This treatment has been effective in keeping my glucose levels normal for the past 5 years.
3.7Patient Review
7/14/20103.3Patient Review
6/24/20102.7Patient Review
7/13/20102.7Patient Review
7/15/20102.7Patient Review
7/16/20102.7Patient Review
10/14/2010 I've been taking this medication for four years now with no issues. It's effective for me.
2.7Patient Review
12/15/2010 I stopped taking Avandia when reports came out, and I felt much better - even lost 10lbs. However, my A1C went up to 7.6. My doctor made me go back on in May, and now I've gained the weight back and feel tired and achy all the time. I'm waiting to see the doctor in September so that I can get off of this medication for good!
2Patient Review
7/19/2010 I was on this medication for six years and it did help with my edema, but I have seen other comments from people over 50 who had similar experiences. My weight gain is due to overeating and now I'm having more heart palpitations and my blood pressure has gone dangerously high. This is something that runs in my family so I know it's not the medication. I will miss one thing about it though; I wasn't allergic to it like some of the other medications I've tried.
1.7Patient Review
8/12/2010 I was on this a while ago but my doctor took me off of it because of the dangers associated with the drug. My new doctor put me back on it, and in just one month I've gained 10 pounds, feel constantly fatigued, have swollen joints, and overall feel terrible. This medication hasn't lowered my blood sugar levels at all, so I'm going to stop taking it. With my high blood pressure and heart rate, I don't think this is a good medication for me.
1.3Patient Review
1/2/2012 I have developed serious heart problems as a result of taking this drug. I have had stents installed, a pacemaker, and multiple heart attacks. This medication has shortened my life span and I would not recommend it to anyone.
Patient Q&A Section about avandia
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the drug Avandia used for?
"Rosiglitazone is used in combination with a diet and exercise regimen to help control blood sugar levels in people with type 2 diabetes. Maintaining normal blood sugar levels can help prevent complications such as kidney damage, blindness, nerve problems, limb loss, and sexual dysfunction."
Answered by AI
What are the side effects of Avandia?
"The most common side effects of Avandia (rosiglitazone) are upper respiratory tract infection, headache, back pain, high blood sugar, fatigue, sinusitis, diarrhea and low blood sugar. However, there are also some serious potential side effects, such as heart failure, heart attack, liver damage and bone fracture."
Answered by AI
Who should not take Avandia?
"AVANDIA should not be taken by people with type 1 diabetes mellitus or those who are in diabetic ketoacidosis. Additionally,AVANDIA should not be taken with insulin."
Answered by AI
Is Avandia same as metformin?
"Avandia contains the active drug rosiglitazone, which belongs to a class of medications called thiazolidinediones. Metformin is the generic version of a drug Glucophage. Metformin belongs to a class of drugs called biguanides."
Answered by AI