Tailored DPP for Prediabetes

Overseen By Lauren E Wisk, PhD

Age: < 65

Sex: Any

Trial Phase: Academic

Sponsor: University of California, Los Angeles

Disqualifiers: Not UCLA undergrad, Not T-UP eligible

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 5

80 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to test a diabetes prevention program tailored for young adults at risk of developing type 2 diabetes. Participants will join a program designed to help them lose weight and reduce diabetes risk through online lessons. The trial will compare this tailored program to a control group receiving other online wellness resources. UCLA undergraduates with a BMI over 25 (23 for Asian students) who have prediabetes or are at high risk are eligible to join. As an unphased trial, participants can contribute to innovative research and access personalized resources that may improve their health.

Do I have to stop taking my current medications for this trial?

The trial information does not specify whether you need to stop taking your current medications. It would be best to discuss this with the trial coordinators for clarification.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research has shown that the Diabetes Prevention Program (DPP) is generally safe and well-tolerated. In previous studies, the DPP lifestyle change program helped people lower their risk of developing type 2 diabetes by 58% over about three years. Participants in these studies lost about 5% to 7% of their body weight, which is important for reducing diabetes risk.

No major safety issues were reported in these studies, suggesting that the program is safe for those wanting to lower their diabetes risk. The program focuses on lifestyle changes, like eating healthier and being more active, which are usually safe and beneficial for most people.

Overall, for those considering joining a trial involving the DPP, research indicates it is a safe option for managing prediabetes. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Researchers are excited about the Tailored Diabetes Prevention Program (DPP) because it offers a personalized approach to managing prediabetes, unlike typical one-size-fits-all lifestyle interventions. This program allows participants to complete lessons online at their own pace, which is a more flexible and accessible option compared to traditional in-person group sessions. By tailoring the intervention, it aims to be more engaging and relevant to each individual's needs, potentially leading to better adherence and outcomes in preventing the progression to diabetes.

What evidence suggests that the tailored DPP intervention could be effective for prediabetes?

Research has shown that the Diabetes Prevention Program (DPP) can significantly reduce the risk of developing type 2 diabetes. Studies have found that lifestyle changes in the DPP can decrease the likelihood of type 2 diabetes by 58%. In this trial, participants in the DPP group will receive a specially designed version of the DPP to address cultural and financial challenges, making it more accessible and potentially more effective for underserved communities. Online versions of the DPP have also succeeded in increasing participation and helping individuals achieve weight loss goals. These results suggest that this tailored DPP could help participants reduce their diabetes risk through weight loss. ^{3 4 6 7 8}

Who Is on the Research Team?

Lauren E Wisk, PhD

Principal Investigator

University of California, Los Angeles

Are You a Good Fit for This Trial?

This trial is for UCLA undergraduate students at risk of type 2 diabetes, particularly those underserved with challenges like food and financial insecurity. Participants should be able to complete online lessons and surveys. Those not meeting the study's specific health criteria or unable to commit to the full duration may be excluded.

Inclusion Criteria

I am a UCLA student with a BMI ≥25 (or ≥23 if Asian) and have prediabetes or am at high risk according to the CDC.

Exclusion Criteria

Participants who are not currently enrolled (either full time or part time) as an undergraduate at UCLA and do not meet criteria for the T-UP Wellness Program.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Online form submission

Baseline Assessment

Participants complete baseline assessments including a 30-minute questionnaire and height/weight measurements

1 week

1 visit (in-person or virtual)

Intervention

Participants engage in the tailored Diabetes Prevention Program (DPP) or control interventions online and asynchronously

9 months

Remote participation

Quarterly Assessments

Participants complete brief REDCap surveys to assess acceptability and self-report weight and physical activity

Throughout intervention

3 surveys (online)

Follow-up

Participants complete a 9-month follow-up assessment including a questionnaire and height/weight measurements

1 week

1 visit (in-person or virtual)

What Are the Treatments Tested in This Trial?

Interventions

• Tailored DPP Intervention

Trial Overview The study tests a tailored version of the UC Diabetes Prevention Program (DPP), aiming for weight loss and diabetes risk reduction in young adults. It compares this intervention with control materials on study habits, alcohol use, and financial literacy provided remotely.

How Is the Trial Designed?

Group I: Diabetes Prevention Program (DPP) group Experimental Treatment 1 Intervention

The DPP group will receive a tailored Diabetes Prevention Program. The DPP group will complete intervention lessons online and asynchronously. Each lesson typically takes on average 15 minutes to complete.

Group II: Control group Active Control 1 Intervention

The control group will receive access to a study habits intervention (fall), alcohol use intervention (winter), and financial literacy intervention (spring). The control group will receive each intervention materials via e-mail for participants to review on their own time. The interventions for the control group will be remote. A research assistant will meet with control participants via Zoom to explain the intervention materials. The Zoom session will take approximately 1 hour.

Who Is Running the Clinical Trial?

University of California, Los Angeles

Lead Sponsor

Trials

1,594

Recruited

10,430,000+

American Diabetes Association

Collaborator

Trials

148

Recruited

102,000+

Citations

1. clinicaltrials.gov clinicaltrials.gov/study/NCT05301413

Social Determinants and a Diabetes Prevention Program ... This novel study is the first to tailor the DPP to address SD cultural and socioeconomic barriers that limit DPP attendance and reduce its effectiveness on ...

2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC1282458/

The Diabetes Prevention Program (DPP) - PubMed Central Lifestyle intervention decreased the incidence of type 2 diabetes by 58% compared with 31% in the metformin-treated group, and information on adherence to these ...

3. researchprotocols.org researchprotocols.org/2025/1/e64405

Virtual Diabetes Prevention Program Tailored to Increase ... The primary aim of the project is to assess the effect of Power-Up versus NDPP on weight loss among men with prediabetes. The secondary aim is ...

4. hopkinsmedicine.org hopkinsmedicine.org/news/newsroom/news-releases/2025/10/ai-powered-diabetes-prevention-program-shows-similar-benefits-to-those-led-by-people

AI-Powered Diabetes Prevention Program Shows Similar ... After 12 months, the study team found 31.7% of AI-DPP participants and 31.9% of human-led DPP participants met the CDC-defined composite ...

5. cdc.gov cdc.gov/pcd/issues/2019/19_0156.htm

Evaluation of a Digital Diabetes Prevention Program ... Our study examined a digitally delivered DPP that removed some barriers to access and increased participation for low-income patients.

6. niddk.nih.gov niddk.nih.gov/about-niddk/research-areas/diabetes/diabetes-prevention-program-dpp

Diabetes Prevention Program (DPP) - NIDDK After about 3 years, the DPP showed that participants in the DPP Lifestyle Change Program lowered their chances of developing type 2 diabetes by 58 percent ...

7. diabetesjournals.org diabetesjournals.org/care/article/46/2/e39/148317/The-National-Clinical-Care-Commission-Report-to

The National Clinical Care Commission Report to Congress In addition, only 4.9% of adults diagnosed by a physician with prediabetes were advised to participate in a diabetes prevention program (51).

8. sciencedirect.com sciencedirect.com/science/article/pii/S2211335524000706

A systematic review of diabetes prevention programs ... Participants achieved 5 to 7 % weight loss, reducing the risk of developing diabetes by 58 %. (Knowler et al., 2002) The 10-year follow-up study, the Diabetes ...