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Alcohol and Sugar Impact on Liver Metabolism

N/A
Waitlist Available
Research Sponsored by University of Texas Southwestern Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 0, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 5, 6, and 7 hours post heavy water consumption
Awards & highlights

Study Summary

This trial will study the effects of alcohol and sugar on the synthesis of new fats in the liver.

Who is the study for?
This trial is for healthy men and women aged 21-45, with a BMI of 18.5-29.9, who drink alcohol lightly to moderately. They must understand English but can't participate if they're pregnant, breastfeeding, have a high BMI (>29.9), take regular medications (except oral contraceptives), or exercise heavily.Check my eligibility
What is being tested?
The study tests how the liver creates fat after drinking alcohol by having participants consume deuterated water and then vodka. Blood samples will be taken before and after this process in two groups: one also consuming sucrose with vodka and another with sucrose alone.See study design
What are the potential side effects?
While deuterated water is not harmful and widely used in studies, potential side effects from the interventions may include typical reactions to alcohol such as nausea, headache, dizziness or general discomfort.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~0, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 5, 6, and 7 hours post heavy water consumption
This trial's timeline: 3 weeks for screening, Varies for treatment, and 0, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 5, 6, and 7 hours post heavy water consumption for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Mean Change in Hepatic De Novo Lipogenesis (DNL)

Trial Design

3Treatment groups
Experimental Treatment
Group I: ETOH + SucroseExperimental Treatment2 Interventions
5 Females will receive deuterated water and drink 1.72 ounces of alcohol in the form of vodka + 7 grams of sucrose and have de novo Lipogenesis measured at 11 time points during and after.
Group II: C. SucroseExperimental Treatment1 Intervention
5 Females will receive deuterated water and drink a solution containing water and 35 grams of sucrose, and have de novo Lipogenesis measured at 11 time points during and after.
Group III: A. ETOHExperimental Treatment1 Intervention
5 Males and 5 Females will receive deuterated water and drink 2.15 ounces of alcohol in the form of vodka and have de novo Lipogenesis measured at 11 time points during and after.

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Who is running the clinical trial?

University of Texas Southwestern Medical CenterLead Sponsor
1,048 Previous Clinical Trials
1,053,791 Total Patients Enrolled

Media Library

ETOH (Other) Clinical Trial Eligibility Overview. Trial Name: NCT04829110 — N/A
Liver Metabolism Research Study Groups: ETOH + Sucrose, A. ETOH, C. Sucrose
Liver Metabolism Clinical Trial 2023: ETOH Highlights & Side Effects. Trial Name: NCT04829110 — N/A
ETOH (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04829110 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the qualifications for individuals to join this research endeavor?

"In order to be eligible for the trial, participants must possess healthy liver metabolism and fall between 21-45 years of age. Only 20 individuals are being admitted into this clinical study."

Answered by AI

How many individuals are participating in this scientific exploration?

"Affirmative. All the information on clinicaltrials.gov points to this trial still being open for recruitment; first posted on November 11th 2021 and last modified March 15th 2022, with a need for 20 individuals from one medical centre."

Answered by AI

Is this research study accepting participants of advanced age?

"The minimum and maximum age for enrollment in this medical study is 21 to 45, as mandated by the inclusion criteria."

Answered by AI

Is this clinical study currently recruiting participants?

"Correct. As per the clinicaltrials.gov data, this medical research study is presently seeking participants and was initially posted on November 11th 2021. The trial requires 20 individuals to be recruited from one site and the details were most recently amended on March 15th 2022."

Answered by AI

Who else is applying?

What state do they live in?
Texas
How old are they?
18 - 65
What site did they apply to?
School of Health Professions at UTSW
What portion of applicants met pre-screening criteria?
Met criteria

How responsive is this trial?

Typically responds via
Email
Recent research and studies
clinicaltrials.govStudy
Alcohol Induced de Novo Lipogenesis in Women
Justin Fletcher 2021. "Alcohol Induced de Novo Lipogenesis in Women". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04829110.
~6 spots leftby Apr 2025
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