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AZD6738 for Myelodysplastic Syndrome
Study Summary
This trial is testing a drug called AZD6738 as a possible treatment for Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
Media Library
- My MDS or CMML has returned after a stem cell transplant.My leukemia has spread to my brain or spinal cord.Your liver function tests should show AST and ALT levels that are not more than 2.5 times the upper limit of normal.My MDS or CMML has returned after a stem cell transplant.I can take care of myself but might not be able to do heavy physical work.I had a transplant less than 100 days ago and am not on strong immune-suppressing drugs.I don't know if I have a splicing factor mutation, but I will test for it before taking the drug.My kidney function, measured by creatinine clearance, is sufficient.I can take care of myself but might not be able to do heavy physical work.My splicing factor mutation test results are available before joining Part 2.My cancer has specific genetic mutations or is wildtype.I agree to use effective birth control during and for 1 week after the study.I have not had major surgery in the last 4 weeks.You are currently participating in another research study.I have not received any live vaccines in the last 4 weeks.My MDS did not respond to specific chemotherapy, or I couldn't tolerate it.I have lower-risk MDS, need regular blood transfusions, and treatments like ESA haven't worked for me.My organ and bone marrow functions are within normal ranges.My MDS is high-risk and didn't respond to specific chemotherapy treatments.I have been diagnosed with acute myeloid leukemia.I am not pregnant, breastfeeding, and can't become pregnant.Your blood clotting levels should not be too high.I have an active hepatitis B or C infection.I am HIV-positive.Your bilirubin levels are normal, unless you have a condition called Gilbert's syndrome, in which case the levels can be slightly elevated but still within a certain range.I haven't had chemotherapy in the last 21 days or five half-lives of the drugs, whichever is longer.I have been diagnosed with ataxia-telangiectasia.I don't have ongoing major side effects from previous treatments.I have severe, ongoing stomach issues that affect how my body absorbs medication.I am 18 years old or older.I do not have any uncontrolled illnesses.I have previously been treated with ATR or DDR inhibitors.I am not taking strong drugs that affect liver enzyme CYP3A4.I have CMML and did not respond well or couldn't tolerate previous HMA chemotherapy.I am not eligible for or have chosen not to undergo stem cell transplantation.I have been diagnosed with MDS or CMML that is getting worse or not going away.I have lower-risk MDS, need regular blood transfusions, and other treatments haven't worked or aren't suitable for me.I have been taking more than 10mg of prednisone or its equivalent daily for up to 14 days before starting the study drug.I have CMML and didn't respond well or couldn't tolerate HMA chemotherapy, or I chose not to receive it.I am 18 years old or older.I haven't taken any experimental drugs within the last 21 days or longer.I have another cancer that hasn't been treated yet.I have not had any heart diseases in the last 6 months.I can swallow and keep down pills.
- Group 1: AZD6738
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Has AZD6738 obtained governmental authorization to be marketed?
"Evaluating the safety of AZD6738, our team at Power provided a rating of 1 due to it being in its initial phase. Thus far there is only scant data regarding both efficacy and security."
How many participants are being accepted in this medical experiment?
"Confirmed. According to clinicaltrials.gov, this research study is currently seeking out participants since its original posting on August 5th 2019 and most recent update on January 13th 2021. A total of fifty-two individuals are needed across four trial sites."
Has this investigation ever been attempted before?
"AZD6738 has been in the research pipeline since 2014 when AstraZeneca launched its first trial which involved 330 patients. After being found safe and effective during Phase 1 & 2 trials, AZD6738 is now part of 24 active clinical studies spread across 92 cities and 20 nations."
Could you elucidate if this clinical trial has any vacancies for participants?
"Per the clinicaltrials.gov listing, recruitment for this experiment is still underway. It was initially posted on August 5th 2019 and modified most recently on January 13th 2021."
Are there any additional investigations that have been done into AZD6738?
"AZD6738 was initially studied in 2014 at a Research Site, with 5 trials now completed. As of the present day, there are 24 active medical studies taking place, many located within Boston Massachusetts."
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