Tolinase

Type 2 Diabetes
Treatment
2 FDA approvals
20 Active Studies for Tolinase

What is Tolinase

TolazamideThe Generic name of this drug
Treatment SummaryGlimepiride is a medication used to treat low blood sugar levels (hypoglycemia). It works similarly to another diabetes medication called Chlorpropamide and belongs to a group of drugs known as sulphonylureas.
Tolazamideis the brand name
Tolinase Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tolazamide
Tolazamide
1995
11

Approved as Treatment by the FDA

Tolazamide, otherwise called Tolazamide, is approved by the FDA for 2 uses like Type 2 Diabetes Mellitus and Type 2 Diabetes .
Type 2 Diabetes Mellitus
Helps manage Type 2 Diabetes Mellitus
Type 2 Diabetes
Helps manage Type 2 Diabetes Mellitus

Effectiveness

How Tolinase Affects PatientsTolazamide is a type of medicine that helps reduce blood sugar levels. It does this by encouraging the pancreas to produce more insulin, though other processes may also be involved. Over time, the body may become less responsive to the effects of tolazamide, but it may still work for some people who have stopped responding to other types of sulfonylurea drugs. Additionally, tolazamide can also cause increased urination.
How Tolinase works in the bodySulfonylureas help the body produce more insulin. They do this by attaching to receptors on the surface of pancreatic cells. This causes the cells to become more electrically charged, which then triggers calcium ions to enter the cell. The increased calcium ions lead to the release of insulin.

When to interrupt dosage

The suggested amount of Tolinase is contingent upon the determined condition. The measure of dosage can be found in the table below, in accordance with the method of administration (e.g. Oral or Tablet - Oral).
Condition
Dosage
Administration
Type 2 Diabetes
250.0 mg, , 500.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral

Warnings

Tolinase has two potential drawbacks, so it should not be utilized while encountering any of the circumstances listed in the following table.Tolinase Contraindications
Condition
Risk Level
Notes
Diabetes Mellitus, Type 1
Do Not Combine
Diabetic Ketoacidosis
Do Not Combine
There are 20 known major drug interactions with Tolinase.
Common Tolinase Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Minor
Tolazamide may increase the anticoagulant activities of (R)-warfarin.
(S)-Warfarin
Minor
Tolazamide may increase the anticoagulant activities of (S)-Warfarin.
Abacavir
Minor
Tolazamide may decrease the excretion rate of Abacavir which could result in a higher serum level.
Abrocitinib
Minor
The metabolism of Abrocitinib can be decreased when combined with Tolazamide.
Aclidinium
Minor
Tolazamide may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Tolinase Toxicity & Overdose RiskTaking too much of a sulfonylurea can cause extremely low blood sugar, which can lead to unconsciousness, seizures, and other serious neurological issues. This is a medical emergency that requires immediate hospital care.

Tolinase Novel Uses: Which Conditions Have a Clinical Trial Featuring Tolinase?

162 ongoing studies are assessing the potential of Tolinase to improve Type 2 Diabetes symptoms.
Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
168 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1

Patient Q&A Section about tolinase

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Tolazamide used for?

"Tolazamide is used to treat high blood sugar levels caused by type 2 diabetes. In type 2 diabetes, your body does not work properly to store excess sugar and the sugar remains in your bloodstream."

Answered by AI

Is Tolazamide still used?

"As of September 15, 2020, tolazamide is no longer available for purchase in the United States."

Answered by AI

What class of drugs is Tolbutamide?

"Tolbutamide is a drug that belongs to a class of drugs called sulfonylureas. It causes your pancreas to release more insulin into the blood stream."

Answered by AI

What is Tolinase used for?

"Tolinase is a diabetes medication that is taken orally. It is typically used in conjunction with diet and exercise to treat type 2 diabetes. If necessary, other diabetes medications may be used in combination with Tolinase. The brand name Tolinase is no longer available, but there may be generic versions available."

Answered by AI

Clinical Trials for Tolinase

Image of KPNC Division of Research in Pleasanton, United States.

MetSense Risk Flag for Type 2 Diabetes

18+
All Sexes
Pleasanton, CA
People with serious mental illness have high risk for type 2 diabetes due to multiple risk factors, including the metabolic side effects of psychotropic medications that are used to treat these conditions. Type 2 diabetes is preventable through lifestyle and pharmacological interventions, but many people with serious mental illness do not receive regular screening for type 2 diabetes risk. In many health care settings, clinical pharmacists are increasingly managing patients with serious mental illness and have expertise in monitoring the metabolic side effects of psychotropic medications. This study evaluates the feasibility and acceptability of using a diabetes prediction model that is based on electronic health record data (the MetSense risk flag) to alert clinical pharmacists about patients who are at high diabetes risk, prompting these clinicians to prioritize diabetes risk management services.
Waitlist Available
Has No Placebo
KPNC Division of ResearchEsti Iturralde, PhD
Image of University of California, Los Angeles in Los Angeles, United States.

Tailored DPP for Prediabetes

17 - 25
All Sexes
Los Angeles, CA
The goal of this study is to enhance reach and uptake of diabetes prevention among young adults, with a focus on recruiting underserved and high-need students who face additional challenges, including food and financial insecurity. The specific aims are: Aim 1 - Evaluate the efficacy of an AYA-tailored version of the UC DPP for mitigating type 2 diabetes risk (i.e., weight change) in a pre/post pilot trial. The investigators hypothesize that the AYA-tailored intervention will be effective at producing 5% weight loss from baseline to program completion (at 9-months). Aim 2 - Assess the feasibility and acceptability of an AYA-tailored version of the UC DPP program. The investigators hypothesize that it will be feasible to recruit the desired number of participants given proposed innovative outreach strategies, and that the AYA-tailored intervention will be deemed acceptable to participants both qualitatively and in regards to their retention in the program at rates similar to the larger UC DPP. The investigators will recruit 80 UCLA undergraduate students. Participants will be asked to complete a brief screening online form to assess eligibility and to collect contact information. The PI and/or Research Assistants (RAs) will reach out to eligible participants to obtain informed consent and enroll them in the pilot trial. The investigators will randomize participants to the tailored DPP cohort vs control cohort. Control participants will be offered the opportunity to participate in the tailored DPP in the following academic year. The tailored DPP intervention will be online and asynchronously. Participants will be asked to complete the intervention lessons on their own time. Each lesson typically takes on average 15 minutes to complete. Control group will receive each intervention materials via e-mail for participants to review on their own time and will receive acceptability surveys. The interventions for the control group will be remote. A research assistant will meet with control participants via Zoom to explain the intervention materials. Control group will receive access to a study habits intervention, alcohol use intervention, and financial literacy intervention. At the end of each quarter (Fall, Winter, and Spring), both control and intervention participants will receive an email with a unique link to a brief REDCap survey to ascertain acceptability of sessions/lessons. Furthermore, participants will complete baseline and 9-month follow-up assessments. Participants will complete a 30 minute questionnaire and height/weight measurements will be collected by a RA. Participants will be asked to self-report weight and physical activity at the end of the fall and winter quarter; data will be collected via brief REDCap survey.
Recruiting
Has No Placebo
University of California, Los AngelesLauren E Wisk, PhD
Have you considered Tolinase clinical trials? We made a collection of clinical trials featuring Tolinase, we think they might fit your search criteria.Go to Trials
Image of The Worship Center Cristian Church in Birmingham, United States.

Black Impact for Heart Health

18+
Male
Birmingham, AL
The goal of this clinical trial is to evaluate the implementation and effectiveness of the Black Impact program-a church-based cardiovascular health (CVH) intervention-in Black men aged 35-70 who are at risk for heart disease, diabetes, obesity, and related conditions. The main questions this study aims to answer are: * Does participation in the Black Impact program improve cardiovascular health metrics (e.g., blood pressure, cholesterol, blood sugar) and health behaviors among Black men at The Worship Center Christian Church (TWC)? * What factors influence the adoption, delivery, and sustainability of the Black Impact program in a faith-based setting? Researchers will compare an immediate-start intervention group and a delayed-start (waitlist control) group to assess both short-term health outcomes and program implementation factors. Participants will: * Attend a 90-minute weekly session for 24 weeks, including 45 minutes of physical activity led by a certified trainer and 45 minutes of health education delivered by trained coaches. * Receive one-on-one support from a community health worker to reduce barriers to care and engage with primary care. * Complete biometric health screenings and surveys at baseline, 12 weeks, and 24 weeks to assess clinical and behavioral outcomes. * Use a smartwatch, blood pressure cuff, and other tools to track progress in real time. * Participate in exit focus groups or interviews to share feedback about the intervention. * A subset of TWC leaders and interventionists (N=15) will also be interviewed to assess implementation, resource needs, and sustainability. This study uses the RE-AIM framework to assess Reach, Effectiveness, Adoption, Implementation, and Maintenance, and aims to inform scalable strategies for improving CVH among Black men in trusted community settings.
Waitlist Available
Has No Placebo
The Worship Center Cristian Church
Have you considered Tolinase clinical trials? We made a collection of clinical trials featuring Tolinase, we think they might fit your search criteria.Go to Trials
Image of Exercise Metabolism and Inflammation Laboratory in Okanagan, Canada.

Aerobic Exercise with Blood Flow Restriction for Type 2 Diabetes

19 - 64
All Sexes
Okanagan, Canada
The goal of this trial is to learn if blood flow restriction training with treadmill walking is possible for individuals living with type 2 diabetes. It will also learn about how the blood flow restriction with treadmill walking could improve health. The main questions it aims to answer are: Is 6 weeks of treadmill walking with blood flow restriction reasonable for people with type 2 diabetes to perform? Does treadmill walking with blood flow restriction training help manage type 2 diabetes better than just treadmill walking? Researchers will compare treadmill walking with blood flow restriction to treadmill walking without blood flow restriction to see if blood flow restriction works to manage type 2 diabetes based on fitness and blood sugar levels. Participants will: Perform treadmill walking with or without blood flow restriction for 96 minutes a week for 6 weeks. Visit the lab before and after the exercise for tests and questionnaires.
Waitlist Available
Has No Placebo
Exercise Metabolism and Inflammation Laboratory (+2 Sites)Martin Senechal, PhD
Image of Jefferson Health New Jersey in Sewell, United States.

Continuous vs Finger-stick Glucose Monitoring for Type 2 Diabetes in Pregnancy

18+
Female
Sewell, NJ
The purpose of this study is to compare patient adherence to blood sugar monitoring during pregnancy using two different measurement methods in pregnancies complicated by pregestational type 2 diabetes (T2DM). Pregnant patients with T2DM are at risk of having larger babies, babies with low sugar levels in the first 24 hours of life, higher rates of cesarean delivery, stillbirth (death of baby inside the womb), and hypertensive or high blood pressure disorders of pregnancy, such as preeclampsia. Prior studies have shown that treating high blood sugars in pregnancy with medications can reduce these risks. To determine the amount of medication needed, recording of blood sugar levels is necessary. This trial aims to determine whether continuous blood sugar monitors have improved patient recording of blood sugar levels over finger stick blood sugar measurements. Patients involved in the study will be assigned to either: 1. Fingerstick glucose monitoring (FSG) 2. Continuous glucose monitoring (CGM) Patients will be randomize in a 1:1 ratio. FSG Group: blood sugar is tested four times daily - once fasting and two hours after every meal (post-prandial). Blood will be tested using a glucometer, and values will be recorded in a blood sugar log from the time of enrollment to the time of delivery. CGM Group: A CGM sensor will be placed on the patient's arm for blood sugar collection every 3-5 minutes. This data is sent to a phone application from the time of enrollment to the time of delivery. These sensors will need to be replaced every 14 days. Percent adherence will be recorded from the time you were randomized to a study group until delivery.
Recruiting
Has No Placebo
Jefferson Health New Jersey (+1 Sites)
Have you considered Tolinase clinical trials? We made a collection of clinical trials featuring Tolinase, we think they might fit your search criteria.Go to Trials
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