Aerobic Exercise for Cancer Survivors

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RM
Overseen ByRyan Marker
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of Colorado, Denver
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores how extra body weight affects fitness and certain health markers in cancer survivors who have completed their treatments. Participants will join a 15-week aerobic exercise program to assess how exercise influences their health post-cancer. The trial seeks individuals diagnosed with breast, prostate, or colorectal cancer, who completed treatment 6 months to 5 years ago, and can commit to a supervised exercise routine.

As an unphased trial, this study offers a unique opportunity to contribute to understanding the role of exercise in improving health outcomes for cancer survivors.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. However, you must not be undergoing any current cancer treatment, including hormonal treatment, to participate.

What prior data suggests that aerobic exercise is safe for cancer survivors?

A previous study showed that aerobic exercise improved the quality of life for cancer patients undergoing chemotherapy, including those with breast and colorectal cancer. Another study found that aerobic exercise enhanced heart and lung fitness in cancer survivors, even for those who had undergone challenging treatments like anthracyclines, which can affect the heart.

Physical activity is widely recommended for cancer survivors. Scientific organizations endorse exercise, including aerobic activities, as safe and beneficial. No major safety concerns have been reported for aerobic exercise in cancer survivors, suggesting it is generally well-tolerated and safe for those who have completed cancer treatment, including individuals with breast, prostate, or colorectal cancer.12345

Why are researchers excited about this trial?

Researchers are excited about aerobic exercise for cancer survivors because it's a non-invasive way to potentially improve health and well-being after cancer treatment. Unlike traditional treatments, which often involve medication or surgery, aerobic exercise simply uses movement to boost physical fitness and mental health. This approach can enhance quality of life, reduce fatigue, and improve heart health without the side effects associated with many medical treatments. Plus, it empowers survivors to take an active role in their recovery.

What evidence suggests that aerobic exercise might be an effective treatment for cancer survivors?

Research has shown that aerobic exercise, which participants in this trial will engage in, greatly benefits cancer survivors. It improves the coordination of the heart and lungs, even for those who have undergone treatments like chemotherapy. Exercise also reduces fatigue, a common side effect of cancer treatment, and lowers the risk of heart disease. For individuals with colorectal cancer, being active after diagnosis is linked to a lower risk of death. Overall, regular aerobic exercise leads to better health outcomes for cancer survivors.12367

Who Is on the Research Team?

RM

Ryan Marker, PT, PhD

Principal Investigator

University of Colorado, Denver

Are You a Good Fit for This Trial?

This trial is for breast, prostate, or colorectal cancer survivors who are overweight or obese. They should have finished their cancer treatments between 6 months and 5 years ago and must be able to do supervised exercise with a doctor's clearance.

Inclusion Criteria

I finished my cancer treatment between 6 months and 5 years ago.
You are able and willing to take part in an exercise program with supervision.
My cancer is either breast, prostate, or colorectal.
See 1 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants engage in a 15-week standardized aerobic exercise intervention

15 weeks
Pre- and post-intervention assessments

Follow-up

Participants are monitored for adherence and physiological responses post-intervention

up to 12 months

What Are the Treatments Tested in This Trial?

Interventions

  • Aerobic Exercise
Trial Overview The study tests how body fat affects fitness levels and the body's response to a standardized 15-week aerobic exercise program in terms of cardiorespiratory fitness (CRF) and insulin-like growth factor-1 (IGF-1).
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: Aerobic exerciseExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Colorado, Denver

Lead Sponsor

Trials
1,842
Recruited
3,028,000+

Citations

Physical Activity and Cancer Care—A Review - PMCThe findings from these studies show that physical activity decreases the severity of side effects of cancer treatment, reduces fatigue, improves quality of ...
Exercise, Cancer & Cardiovascular Disease: Clinician Advice?Exercise has been shown to improve cardiovascular outcomes in patients with cancer even when initiated before the diagnosis of cancer. This was demonstrated in ...
Effects of Aerobic Exercise on Cardiorespiratory Fitness ...Although aerobic exercise improves CRF in anthracycline-treated long-term BCS, the response was less than one-half that observed in cancer-naive subjects.
Cardio-Oncology Rehabilitation for Cancer Survivors With ...Recent data from a large noncontrolled study showed that exercise-based CR was associated with improve cardiorespiratory fitness and survival in ...
Grading Physical Activity & Cancer Survivors: Umbrella ReviewIn colorectal cancer, both strong and highly suggestive evidence showed that post-diagnosis physical activity reduced total mortality,(Qiu et al., 2020) while ...
Physical activity guidelines in oncology: A systematic ...This review aims to summarize the recommendations endorsed by scientific societies regarding physical activity for patients with cancer.
Exercise-based interventions for preventing and treating ...The 5-year relative survival rate for all cancers was 69% from 2014 to 2020 [2]. In the United States, it is estimated that there are more than ...
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