20 Participants Needed

Aerobic Exercise Timing for Obesity

(TANDEM Trial)

JL
SP
Overseen ByShelby Panter, MS
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

What is the purpose of this trial?

This study plans to learn more about metabolic responses to aerobic exercise at different times of the day (morning or evening) under fasting versus fed conditions.

Will I have to stop taking my current medications?

The trial requires that you do not regularly use medications that significantly impact appetite, weight, energy metabolism, heart rate, or sleep. If you are on such medications, you may need to stop taking them to participate.

What data supports the effectiveness of the treatment Aerobic Exercise, Physical Activity, Cardiovascular Exercise, Fitness Training for obesity?

Research shows that adding aerobic exercise to a weight management program can significantly improve fitness, body measurements, and psychological well-being in people with obesity. Studies suggest that engaging in more than 150 minutes of moderate-intensity aerobic activity per week can help prevent weight gain and improve overall health.12345

Is aerobic exercise safe for people with obesity?

Aerobic exercise is generally safe for people with obesity, as studies show high adherence and retention rates in exercise programs, and it is often used to improve health markers in this population.678910

How does the timing of aerobic exercise differ as a treatment for obesity?

This treatment is unique because it explores the impact of exercising at different times of the day (morning vs. evening) on energy balance and weight regulation in people with obesity, which is not typically considered in standard exercise programs.25101112

Research Team

SC

Seth Creasy, PhD

Principal Investigator

University of Colorado, Denver

Eligibility Criteria

This trial is for adults who are generally healthy but living with obesity. Participants should be interested in how aerobic exercise affects metabolism under different conditions, such as fasting or after eating.

Inclusion Criteria

No plans to relocate within the next 6 months
For Females: Not currently pregnant or lactating, not pregnant within the past 6 months, not planning to become pregnant in the next 6 months
Have a primary care physician (or are willing to establish care with a primary care physician prior to study enrollment) to address medical issues which may arise during screening or study procedures
See 11 more

Exclusion Criteria

Diabetes (fasting glucose >/=126 mg/dL or Hemoglobin A1C >/=6.5%) as measured during the screening visit
Nicotine use (past 6 months)
LDL cholesterol >200 mg/dL as measured on the screening visit
See 25 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants engage in aerobic exercise under different conditions (fasted/fed, AM/PM) to study metabolic responses

5 days per condition
4 visits (in-person) for each condition

Follow-up

Participants are monitored for metabolic changes and energy expenditure after exercise sessions

1-2 weeks

Treatment Details

Interventions

  • Aerobic Exercise
Trial Overview The TANDEM Study is testing the effects of aerobic exercise on metabolism when done at various times (morning vs evening) and states (fasting vs fed). It aims to understand how timing and nutrient intake influence metabolic responses.
Participant Groups
1Treatment groups
Experimental Treatment
Group I: TANDEM ExerciseExperimental Treatment4 Interventions
Participants in this arm will engage in morning aerobic exercise while in a fasted state, morning aerobic exercise while in a fed state, evening aerobic exercise while in a fasted state, and evening aerobic exercise while in a fed state in a randomly assigned order

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Colorado, Denver

Lead Sponsor

Trials
1,842
Recruited
3,028,000+

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Collaborator

Trials
2,513
Recruited
4,366,000+

Findings from Research

In a randomized controlled trial involving 31 morbidly obese participants, both aerobic training (AT) and resistance training (RT) significantly improved health-related fitness measures compared to a control group, including enhancements in walking distance, skin-fold thickness, and psychological factors like self-efficacy.
RT showed additional benefits over the control group in reducing BMI and waist circumference, indicating that while both exercise types are effective, resistance training may offer extra advantages in certain anthropometric measures.
The efficacy of 12 weeks supervised exercise in obesity management.Herring, LY., Wagstaff, C., Scott, A.[2015]
In a study involving 17.9-year-old male patients with obesity, a novel interval training method targeting respiratory muscles (RMIT) combined with a body weight reduction program led to significant improvements in exercise tolerance and reduced perceived effort during heavy-intensity cycling.
RMIT not only decreased the cardiorespiratory burden but also increased peak pulmonary oxygen uptake and time to exhaustion, demonstrating its efficacy in enhancing the integrative response to exercise in young patients with obesity.
Respiratory Muscle Interval Training Improves Exercise Capacity in Obese Adolescents during a 3-Week In-Hospital Multidisciplinary Body Weight Reduction Program.Salvadego, D., Tringali, G., De Micheli, R., et al.[2023]
To effectively prevent weight gain and regain after weight loss, adults should engage in more than 150 minutes, ideally 300 minutes, of moderate-intensity aerobic activity each week.
For significant weight and fat loss, a minimum of 300 to 420 minutes of moderate-intensity aerobic exercise per week is necessary, while the amount needed to reduce central fat may be less than that required for overall weight loss.
Physical activity in the management of obesity in adults: A position statement from Exercise and Sport Science Australia.Johnson, NA., Sultana, RN., Brown, WJ., et al.[2021]

References

The efficacy of 12 weeks supervised exercise in obesity management. [2015]
Respiratory Muscle Interval Training Improves Exercise Capacity in Obese Adolescents during a 3-Week In-Hospital Multidisciplinary Body Weight Reduction Program. [2023]
Physical activity in the management of obesity in adults: A position statement from Exercise and Sport Science Australia. [2021]
Impact of training modes on fitness and body composition in women with obesity: A systematic review and meta-analysis. [2022]
Influences of Resistance versus Aerobic Exercise on Physiological and Physical Fitness Changes in Previously Inactive Men with Obesity: A Prospective, Single-Blinded Randomized Controlled Trial. [2022]
Comparison of linear periodized and non-periodized combined training in health markers and physical fitness of adults with obesity: Clinical trial protocol. [2020]
Evaluation of exercise prescription for hypertensive obese men by ventilatory threshold. [2019]
Effects of regular aerobic exercise on vascular function in overweight or obese older adults: A systematic review and meta-analysis. [2023]
Sequential effects of aerobic exercise training and weight loss on risk factors for coronary disease in healthy, obese middle-aged and older men. [2019]
Effect of Morning and Evening Exercise on Energy Balance: A Pilot Study. [2022]
11.United Statespubmed.ncbi.nlm.nih.gov
Readiness to Perform Aerobic Activity in Adults With Obesity: A Thematic Analysis of Online Surveys. [2020]
Effect of different types of regular exercise on physical fitness in adults with overweight or obesity: Systematic review and meta-analyses. [2021]
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