Equanil

Chronic Pain, Anxiety Disorders, Musculoskeletal Diseases
Treatment
20 Active Studies for Equanil

What is Equanil

MeprobamateThe Generic name of this drug
Treatment SummaryMeprobamate is a drug used to reduce anxiety and help people relax. It is mainly used for short-term relief of insomnia, but has largely been replaced by benzodiazepines. In some cases, Meprobamate can also help prevent seizures, although this effect may not work for larger seizures. Meprobamate is a controlled substance in the United States.
Meprobamateis the brand name
image of different drug pills on a surface
Equanil Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Meprobamate
Meprobamate
1973
18

Effectiveness

How Equanil Affects PatientsMeprobamate is a drug used to reduce anxiety. It used to be the most popular anxiety-relieving drug but has since been replaced by benzodiazepines. It is less likely to make the user feel sleepy compared to similar drugs, but it can make generalized tonic-clonic seizures worse. Meprobamate can also be used as a sleeping aid, but it is only recommended as a last resort.
How Equanil works in the bodyMeprobamate works by binding to certain nerve cells in the brain, which leads to calming and pain-relieving effects. Scientists are not sure exactly how it works, but it is believed to act on the thalamus and limbic system of the brain, which are involved in controlling sleep, relaxation, and pain.

When to interrupt dosage

The recommended dosage of Equanil is contingent upon the diagnosed affliction, including Musculoskeletal Diseases, Anxiety Disorders and Chronic Pain. The measure of dosage fluctuates as per the method of administration indicated in the table below.
Condition
Dosage
Administration
Musculoskeletal Diseases
, 400.0 mg, 200.0 mg
, Tablet, Tablet - Oral, Oral
Anxiety Disorders
, 400.0 mg, 200.0 mg
, Tablet, Tablet - Oral, Oral
Chronic Pain
, 400.0 mg, 200.0 mg
, Tablet, Tablet - Oral, Oral

Warnings

Equanil has two contraindications, so it should not be utilized when encountering any of the ailments listed in the following table.Equanil Contraindications
Condition
Risk Level
Notes
Acute Coryza
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Equanil.
Common Equanil Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Meprobamate may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Deutetrabenazine
Major
The risk or severity of sedation and somnolence can be increased when Meprobamate is combined with Deutetrabenazine.
Ethanol
Major
Meprobamate may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Meprobamate is combined with Oliceridine.
Sodium oxybate
Major
Meprobamate may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Equanil Toxicity & Overdose RiskOverdosing on meprobamate can lead to a coma, muscle paralysis, difficulty breathing, shock, fatigue, unresponsiveness, and even death in some cases. A single case study reported a successful survival after consuming 40 g of meprobamate.
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Equanil Novel Uses: Which Conditions Have a Clinical Trial Featuring Equanil?

358 active trials are presently examining the potential of Equanil to alleviate Chronic Pain, Musculoskeletal Diseases and Anxiety Disorders.
Condition
Clinical Trials
Trial Phases
Anxiety Disorders
56 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 3, Early Phase 1
Musculoskeletal Diseases
2 Actively Recruiting
Not Applicable, Phase 2, Phase 3
Chronic Pain
129 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 3, Early Phase 1, Phase 1

Equanil Reviews: What are patients saying about Equanil?

4.3Patient Review
1/12/2012
Equanil for Anxious
I've found 200mg of Equinil to be really effective in the past, but I stopped taking it a while ago because I thought it was no longer being manufactured. However, now that I see it's still an option, I'm going to look into getting a prescription again. It leads to much better days after a good night's sleep!
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Patient Q&A Section about equanil

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Equanil a tranquilizer?

"The drug Equanil is a tranquilizer used to treat anxiety for a short amount of time."

Answered by AI

What is Equanil used for?

"This action results in a reduction in anxiety.

This medication is for short-term use to treat anxiety and nervousness. It acts on certain centers in the brain to help calm the nervous system. This leads to a reduction in anxiety."

Answered by AI

Is meprobamate still prescribed?

"Meprobamate is no longer a commonly prescribed medication, but it is still available for purchase. Currently, only generic versions of the drug are available, as all of the brand products have been discontinued."

Answered by AI

What type of drug is Equanil?

"Meprobamate is a medication used to treat anxiety disorders or to provide short-term relief from anxiety symptoms in adults and children aged 6 and older. Meprobamate belongs to a class of medications called tranquilizers. Its mode of action is by slowing down brain activity to induce relaxation."

Answered by AI

Clinical Trials for Equanil

Image of Vanderbilt University Medical Center in Nashville, United States.

Lidocaine Infusions for Postoperative Pain

18+
All Sexes
Nashville, TN
The goal of this single-center, pragmatic, randomized, blinded, placebo-controlled trial is to evaluate the impact of intravenous (IV) lidocaine within the existing Enhanced Recovery After Surgery (ERAS)program on outcomes in patients after major abdominal surgery. The main questions the trial aims to answer are: The primary hypothesis is that utilization of IV lidocaine as part of a perioperative multimodal pain regimen will result in a reduction in hospital Case Mix Index-Adjusted Resource Length of Stay (CARLOS). The secondary hypotheses are that lidocaine infusion will result in a reduction in total inpatient opioid consumption (oral morphine milligram equivalents, oMMEs) and pain scores, and improved surgical outcomes (including return of bowel function, ileus, nausea, rapid responses called, surgical site infections, and ICU transfers), while also having minimal incidence of side effects (including double/blurry vision, tinnitus, sedation, and adverse events requiring early cessation).
Phase 4
Waitlist Available
Vanderbilt University Medical CenterDanial Shams, MD
Have you considered Equanil clinical trials? We made a collection of clinical trials featuring Equanil, we think they might fit your search criteria.Go to Trials
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Virtual Reality for Cancer

18 - 90
All Sexes
Jacksonville, FL
This clinical trial tests the safety, tolerability, and effectiveness of a virtual reality intervention to improve psychological symptom burden for cancer patients undergoing treatment. Virtual reality (VR) is a technology that allows users to experience and interact with three-dimensional, computer-generated environments that simulate the real world or imagined settings. The VR intervention consists of a preloaded with immersive environments designed to engage the senses through simulated sights and sounds. This may include a walk through of a serene forest, exploring vibrant coral reefs, swimming with dolphins, or standing at the base of a majestic waterfall. These environments are created to provide a relaxing and engaging experience. Completing the VR intervention may be a safe and effective way to improve quality of life, reduce anxiety, enhance focus, and promote healthy living for cancer patients undergoing treatment.
Recruiting
Has No Placebo
Mayo Clinic in FloridaJuan C. Cardenas Rosales, MD
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Erector Spinae Plane Block for Pain

21 - 75
All Sexes
Cleveland, OH
As per usual care for spine surgery, participants will have their back cleaned with alcohol and a needle will be placed using ultrasound for the ESP block. Through the needle, a small catheter will be placed in the participants back and the needle removed. Approximately one hour prior to the start of surgery, a numbing medication (ropivacaine, similar to Novocaine) in combination with dexmedetomidine (a pain medicine that is used in nerve block and that is not a narcotic) and contrast dye (iohexol) will be injected through the catheter. Participants will then go through the QST procedure (test of buzzing sensation and temperature sensation through pads applied to their skin) to assess the numb areas and then head to the operating room. In the operating room, the catheter will be removed after the surgeon obtains baseline CT scan images of the spine. Once surgery is completed, investigators will record pain scores over the next four days in the hospital and the amount of pain medication needed for controlling pain related to the surgery.
Recruiting
Has No Placebo
University Hospitals Cleveland Medical CenterSalim Hayek, MD
Have you considered Equanil clinical trials? We made a collection of clinical trials featuring Equanil, we think they might fit your search criteria.Go to Trials
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Online Parent Education for Child Anxiety

18+
All Sexes
Boston, MA
The investigators are doing this research to test whether parents of children ages 2-7 can better manage their child's anxiety by completing a brief, online, self-guided parent education program. One way to provide anxiety management skills to more children, and to potentially prevent worsening outcomes, is to offer online and self-guided educational programs that parents can complete without a clinician. This randomized trial will evaluate the effects of two brief, online, self-guided parent education programs designed to improve parents' understanding of anxiety and teach parents way to help their children cope with anxiety. Parents will be randomly assigned to one of the three programs. The main aim of the study is to examine whether the parent programs, compared to an educational control reduce parental accommodation of anxiety across a 1-, 4-, and 8-month follow-up period. As a secondary aim, the investigators will explore whether the parent programs reduce children's anxiety symptoms over the 8-month follow-up period. Results will inform the development of a scalable, low-cost model for promoting access to evidence-based treatment to young children.
Recruiting
Online Trial
Massachusetts General Hospital
Image of Walter Reed National Military Medical Center in Bethesda, United States.

Corticosteroid Injections for Osteoarthritis

18+
All Sexes
Bethesda, MD
The goal of this clinical trial is to find out which type of steroid medicine, when added to a standard pain-control injection during total knee replacement surgery, works best at reducing pain, limiting opioid use, and improving recovery in adults undergoing surgery for severe knee arthritis or injury. The main questions it aims to answer are: Does adding a steroid to the injection improve pain control and reduce opioid use after surgery? Is the newer extended-release steroid (Zilretta) more effective and safer-especially for patients with diabetes-than the traditional steroid (methylprednisolone)? Researchers will compare: Standard pain-control injection alone Standard injection plus methylprednisolone Standard injection plus Zilretta to see which option provides better pain relief, less opioid use, and improved knee function. (Patients with diabetes or prediabetes will only be in the standard injection or Zilretta groups so researchers can study whether Zilretta is safer for blood sugar control.) Participants will: Be randomly assigned to one of the study groups during their total knee replacement surgery Receive the assigned pain-control injection around the knee joint Be followed after surgery to measure: Pain levels Opioid pain medication use Knee movement (range of motion) Whether another procedure (such as manipulation under anesthesia) is needed if the knee becomes too stiff Patient-reported outcome surveys about pain and function
Phase 2 & 3
Waitlist Available
Walter Reed National Military Medical CenterJohn P Cody, MD
Have you considered Equanil clinical trials? We made a collection of clinical trials featuring Equanil, we think they might fit your search criteria.Go to Trials
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