Serzone

Depression

Treatment

1 FDA approval

20 Active Studies for Serzone

Treatment for

Depression

What is Serzone

NefazodoneThe Generic name of this drug

Treatment SummaryNefazodone hydrochloride (brand name Serzone) was an antidepressant drug made by Bristol-Myers Squibb. In 2003, it was discontinued in some countries due to a very small risk of liver damage. In rare cases, it was linked to a need for a liver transplant or death. On May 20, 2004, Bristol-Myers Squibb stopped selling Serzone in the United States.

Serzoneis the brand name

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Serzone Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Serzone

Nefazodone

1994

Approved as Treatment by the FDA

Nefazodone, otherwise known as Serzone, is approved by the FDA for 1 uses like Depression .

Depression

Effectiveness

How Serzone Affects PatientsNefazodone is a medication used to treat major depression. It is similar to the antidepressant trazodone, but works differently, and has fewer risks of serious cardiovascular problems or insomnia than other antidepressants.

How Serzone works in the bodyNefazodone works on two different systems in the body. First, it increases the amount of serotonin available to interact with serotonin receptors. Second, it blocks the effects of norepinephrine, a chemical that helps to regulate the body's response to stress. Nefazodone also has less significant effects on other receptors, like benzodiazepine and cholinergic receptors.

When to interrupt dosage

The proposed measure of Serzone is contingent upon the diagnosed condition. The quantity of dosage additionally depends on the approach of delivery (e.g. Tablet or Tablet - Oral) documented in the table below.

Condition

Dosage

Administration

Depression

, 100.0 mg, 200.0 mg, 250.0 mg, 150.0 mg, 50.0 mg

, Oral, Tablet, Tablet - Oral

Warnings

Serzone Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

Liver

Do Not Combine

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Serzone.

Common Serzone Drug Interactions

Drug Name

Risk Level

Description

(R)-warfarin

Major

The metabolism of (R)-warfarin can be decreased when combined with Nefazodone.

(S)-Warfarin

Major

The metabolism of (S)-Warfarin can be decreased when combined with Nefazodone.

1,2-Benzodiazepine

Major

The metabolism of 1,2-Benzodiazepine can be decreased when combined with Nefazodone.

3,5-diiodothyropropionic acid

Major

The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Nefazodone.

5-androstenedione

Major

The metabolism of 5-androstenedione can be decreased when combined with Nefazodone.

Serzone Toxicity & Overdose RiskIn some cases, taking nefazodone can result in a dangerous form of liver failure.

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Serzone Novel Uses: Which Conditions Have a Clinical Trial Featuring Serzone?

Currently, 601 active clinical trials are underway to explore the possible utilization of Serzone in addressing Depression.

Condition

Clinical Trials

Trial Phases

Depression

337 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 4, Phase 3

Serzone Reviews: What are patients saying about Serzone?

5Patient Review

1/23/2013

Serzone for Major Depressive Disorder

Since returning from Vietnam in 1971 and diagnosed at that time with PTSD I was subjected to 11 years of trial and error with all drugs. Nefazadone has been the best for me and highly reccomended. Man what a difference I see when NOT taking it for a couple of days.

5Patient Review

9/28/2013

Serzone for Depression

I was diagnosed with PTSD, panic disorder, insomnia and depression six months ago. I started taking ATIVAN but didn't like the effects, so my doctor put me on colozapam. It works OK but I still have angry outbursts, so now I am trying nefazadone. So far it seems to be working.

5Patient Review

1/1/2015

Serzone for Depression

Nefazadone/sera zone has been a life-changing medication for me. After trying 7 different antidepressants that didn't work, I was finally prescribed this drug about 17 years ago. It's helped me immensely and I'm now looking to start my doctoral degree. I would love to do research related to this drug and its efficacy in treating depression and ADHD.

5Patient Review

1/15/2022

Serzone for Depression

Nefazodone's recent availability has been a godsend. It has really helped with my depression and anxiety, to the point where I've been taking it for over 20 years without any side effects. Honestly, none of the other medications I tried did anything remotely as effective as this one when it comes to reducing my anxiety.

5Patient Review

5/12/2012

Serzone for Depression

I've been taking this medication for over 20 years, but recently I haven't been able to get it because of backorders from the manufacturer. Do you know what's causing the issue and if there's a comparable substitute?

View All Reviews

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Patient Q&A Section about serzone

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Why is nefazodone no longer used?

"The antidepressant nefazodone hydrochloride (Serzone) is being discontinued by the manufacturer due to concerns of hepatotoxicity. The last day of sale will be Nov. 27, 2003."

Answered by AI

What kind of drug is Serzone?

"SERZONE works by blocking the reuptake of serotonin, a neurotransmitter in the brain, by neurons. This action increases the level of serotonin in the brain and helps relieve depression.

SERZONE is an antidepressant that is taken orally. It works by blocking the reuptake of serotonin, a neurotransmitter, by neurons. This action increases the level of serotonin in the brain and helps relieve depression."

Answered by AI

Is Serzone still prescribed?

"The brand medication of Nefazodone, Serzone, was discontinued in 2003 in the United States due to the rare occurrence of severe liver damage."

Answered by AI

Is Serzone an SSRI or an SNRI?

"Nefazodone is not in the same class of drugs as the serotonin reuptake inhibitors (SSRIs), the tricyclic antidepressants (TCAs), or the monoamine oxidase (MAO) inhibitors. It is similar to another antidepressant, trazodone (Desyrel), in terms of how it works. The FDA approved nefazodone in December 1994."

Answered by AI