Your session is about to expire
What is Serzone
NefazodoneThe Generic name of this drug
Treatment SummaryNefazodone hydrochloride (brand name Serzone) was an antidepressant drug made by Bristol-Myers Squibb. In 2003, it was discontinued in some countries due to a very small risk of liver damage. In rare cases, it was linked to a need for a liver transplant or death. On May 20, 2004, Bristol-Myers Squibb stopped selling Serzone in the United States.
Serzoneis the brand name
Serzone Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Serzone
Nefazodone
1994
33
Approved as Treatment by the FDA
Nefazodone, otherwise known as Serzone, is approved by the FDA for 1 uses like Depression .Depression
Effectiveness
How Serzone Affects PatientsNefazodone is a medication used to treat major depression. It is similar to the antidepressant trazodone, but works differently, and has fewer risks of serious cardiovascular problems or insomnia than other antidepressants.
How Serzone works in the bodyNefazodone works on two different systems in the body. First, it increases the amount of serotonin available to interact with serotonin receptors. Second, it blocks the effects of norepinephrine, a chemical that helps to regulate the body's response to stress. Nefazodone also has less significant effects on other receptors, like benzodiazepine and cholinergic receptors.
When to interrupt dosage
The proposed measure of Serzone is contingent upon the diagnosed condition. The quantity of dosage additionally depends on the approach of delivery (e.g. Tablet or Tablet - Oral) documented in the table below.Condition
Dosage
Administration
Depression
, 100.0 mg, 200.0 mg, 250.0 mg, 150.0 mg, 50.0 mg
, Oral, Tablet, Tablet - Oral
Warnings
Serzone ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Liver
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Common Serzone Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Major
The metabolism of (R)-warfarin can be decreased when combined with Nefazodone.
(S)-Warfarin
Major
The metabolism of (S)-Warfarin can be decreased when combined with Nefazodone.
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be decreased when combined with Nefazodone.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Nefazodone.
5-androstenedione
Major
The metabolism of 5-androstenedione can be decreased when combined with Nefazodone.
Serzone Toxicity & Overdose RiskIn some cases, taking nefazodone can result in a dangerous form of liver failure.
Serzone Novel Uses: Which Conditions Have a Clinical Trial Featuring Serzone?
Currently, 601 active clinical trials are underway to explore the possible utilization of Serzone in addressing Depression.Condition
Clinical Trials
Trial Phases
Depression
698 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 1, Early Phase 1, Phase 4
Serzone Reviews: What are patients saying about Serzone?
5Patient Review
1/23/2013 Since returning from Vietnam in 1971 and diagnosed at that time with PTSD I was subjected to 11 years of trial and error with all drugs. Nefazadone has been the best for me and highly reccomended. Man what a difference I see when NOT taking it for a couple of days.
5Patient Review
9/28/2013 I was diagnosed with PTSD, panic disorder, insomnia and depression six months ago. I started taking ATIVAN but didn't like the effects, so my doctor put me on colozapam. It works OK but I still have angry outbursts, so now I am trying nefazadone. So far it seems to be working.
5Patient Review
1/1/2015 Nefazadone/sera zone has been a life-changing medication for me. After trying 7 different antidepressants that didn't work, I was finally prescribed this drug about 17 years ago. It's helped me immensely and I'm now looking to start my doctoral degree. I would love to do research related to this drug and its efficacy in treating depression and ADHD.
5Patient Review
1/15/2022 Nefazodone's recent availability has been a godsend. It has really helped with my depression and anxiety, to the point where I've been taking it for over 20 years without any side effects. Honestly, none of the other medications I tried did anything remotely as effective as this one when it comes to reducing my anxiety.
5Patient Review
5/12/2012 I've been taking this medication for over 20 years, but recently I haven't been able to get it because of backorders from the manufacturer. Do you know what's causing the issue and if there's a comparable substitute?
5Patient Review
3/12/2022 I'm so glad that Nefazodone is available again. This medication has been a life-changer for me, helping with my anxiety in a way that nothing else has ever done before. If you're struggling with this issue, I recommend checking out the Facebook Support group "Nefazodone Shortage Survivors and Support."
5Patient Review
4/28/20105Patient Review
10/18/2010 I've been taking this for 10 years and it's really helped me. I tried other antidepressants before this one, but the side effects were too much to handle. With this medication, my liver tests have come back fine and there's no nausea if I take it with food. It's allowed me to live a normal life again and I'm very grateful for that.
5Patient Review
9/13/2013 I was unable to get assistance with getting the medications. Can't afford it. No income, unemployed for over 2 years.
5Patient Review
4/28/20105Patient Review
10/18/2010 I've been taking this medication for a decade and it has really improved my quality of life. I've tried other antidepressants that come with nasty side effects, but this one is much more tolerable. So long as I take it with food, I don't experience any nausea either.
5Patient Review
1/23/2013 Since I was diagnosed with PTSD after returning from Vietnam in 1971, I've tried a lot of different medications. Nefazadone has been the best for me by far, and I highly recommend it to others. It's made such a difference in my life that it's hard to go even a couple days without it.
5Patient Review
5/12/2012 I've been taking this medication for over 20 years, but recently I haven't been able to get it because of manufacturer backorders. Do you know what the problem is and if there's a comparable substitute?
5Patient Review
9/28/2013 I've been dealing with some serious mental health issues for the past six months, including PTSD, severe panic disorder, insomnia and depression. I was originally prescribed Ativan, but didn't like the way it made me feel. So then my doctor put me on colozapam, which helped a little bit but I still had angry outbursts. Today is my first day taking nefazadone and so far it seems to be working well.
5Patient Review
1/1/2015 After trying 7 antidepressants that didn't work 20 years ago, I'm hyperactive also, I finally was prescribed nefazadone/sera zone about 17 years ago. It's been a blessing. I finished my master's degree 5 years ago and looking to start my doctoral.
5Patient Review
9/13/2013 I was unable to get assistance with getting the medications. I couldn't afford it and have been unemployed for over 2 years.
5Patient Review
1/15/2022 Nefazodone has been re-stocked and I am so grateful. This medication has done worlds of good for my depression and anxiety-- better than any other antidepressant I've tried in the 20 years I've been taking it.
5Patient Review
3/12/2022 I'm so glad that Nefazodone is available again. I've been taking it for over 20 years and it's the only thing that helps with my anxiety. There's a great Facebook support group called "Nefazodone Shortage Survivors and Support" where you can find more information about this medication.
4.7Patient Review
5/31/2012 I've been taking this medication for 10 years and it's worked great for me, but now my pharmacy is having trouble filling my prescription. I'm not sure what's going on, but I hope they can continue to provide this product.
4.7Patient Review
9/29/2013 I've been on this medication for a prolonged period of time and it has drastically improved my quality of life. That being said, sometimes it can be difficult to find my 200 mg dose in stores.
4.7Patient Review
8/10/2019 I miss this medication dearly; it was the only one that effectively treated my depression and anxiety. The side effects, while not ideal, were manageable for me. I think it's really important that this drug be available again in Australia.
4.7Patient Review
8/10/2019 I took this medication for several years before it was withdrawn from the market in Australia. It was the only medication that treated my depression & anxiety. Side effects for me were heavy sedation (especially in mornings), restless legs, nausea, weight loss. But overall, I think the side effects were worth it. My liver function was monitored via blood tests and it was fine. Bring this back to the market in Australia; it is vital! There is no equivalent!
4.7Patient Review
5/31/2012 I've been taking this medication for 10 years and have had great results. However, my pharmacist is now having difficulty filling my prescription. I would like to know why this is happening and if there are any alternatives available.
4.7Patient Review
9/29/2013 I've been on this medication for a long time and it has really changed my life for the better. That said, I have run into issues in the past where my pharmacist wasn't able to fill my script for the 200mg dose that I need.
3Patient Review
6/6/2022 I just started this medication and I'm already feeling drowsy. I only took 100mg, is this normal? Will the effects wear off over time?
3Patient Review
6/6/2022 I've just started taking this medication, and I'm already feeling very drowsy. I only took 100mg, is this normal? Will the side effects go away?
2.3Patient Review
11/4/2012 My blood pressure rose to an unhealthy level after only a couple weeks, and I experienced other issues like shaking and memory problems. I had to go the hospital, where they said everything was fine and charged me $6,000.
2.3Patient Review
11/4/2012 My blood pressure spiked alarmingly after only a couple weeks of taking this medication. I also started shaking and forgetting things. I had to go to the hospital, where they said there was no issue. Without insurance, this treatment cost me $6,000 out of pocket.
Patient Q&A Section about serzone
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Why is nefazodone no longer used?
"The antidepressant nefazodone hydrochloride (Serzone) is being discontinued by the manufacturer due to concerns of hepatotoxicity. The last day of sale will be Nov. 27, 2003."
Answered by AI
What kind of drug is Serzone?
"SERZONE works by blocking the reuptake of serotonin, a neurotransmitter in the brain, by neurons. This action increases the level of serotonin in the brain and helps relieve depression.
SERZONE is an antidepressant that is taken orally. It works by blocking the reuptake of serotonin, a neurotransmitter, by neurons. This action increases the level of serotonin in the brain and helps relieve depression."
Answered by AI
Is Serzone still prescribed?
"The brand medication of Nefazodone, Serzone, was discontinued in 2003 in the United States due to the rare occurrence of severe liver damage."
Answered by AI
Is Serzone an SSRI or an SNRI?
"Nefazodone is not in the same class of drugs as the serotonin reuptake inhibitors (SSRIs), the tricyclic antidepressants (TCAs), or the monoamine oxidase (MAO) inhibitors. It is similar to another antidepressant, trazodone (Desyrel), in terms of how it works. The FDA approved nefazodone in December 1994."
Answered by AI