Calorie Reduction for Obesity
(CARE Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial requires that you stop taking certain medications, including antipsychotic agents, monoamine oxidase inhibitors, systemic corticosteroids, antibiotics for HIV or TB, chemotherapeutic drugs, and prescription weight loss medications.
What data supports the effectiveness of the treatment Energy Reduction for obesity?
Is calorie reduction generally safe for humans?
How does the treatment 'Energy Reduction' for obesity differ from other treatments?
The 'Energy Reduction' treatment for obesity focuses on reducing calorie intake, which can be done through moderate or severe caloric restriction. This approach is unique because it emphasizes the amount of energy consumed rather than the specific types of nutrients, and it can lead to significant short-term weight loss, although maintaining this loss requires ongoing care and lifestyle changes.111121314
What is the purpose of this trial?
This research study will compare two weight loss programs that provide different recommendations for how to reduce your energy (or calorie) intake to achieve weight loss in an effort to determine if fixed calorie reduction or varied calorie reduction is more effective for weight loss.
Research Team
Gareth R Dutton, PhD
Principal Investigator
University of Alabama at Birmingham, Department of Medicine, Division of Preventive Medicine
Eligibility Criteria
This trial is for adults aged 21-75 with obesity (BMI of 30-50). It's not suitable for those with certain chronic diseases, uncontrolled high blood pressure, recent heart attacks or strokes, major psychiatric disorders, or a history of significant weight loss or bariatric surgery. Pregnant women and those planning pregnancy are excluded.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants follow either a fixed or variable calorie reduction plan to achieve weight loss
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Energy Reduction
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Alabama at Birmingham
Lead Sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator