Hemp Hull WFI for IBS Diarrhea
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial examines how a fiber bar made from hemp hulls affects individuals with irritable bowel syndrome (IBS) and bile acid-induced diarrhea. The researchers aim to determine if consuming two bars daily for 21 days can alleviate symptoms by altering intestinal function. Suitable participants have been diagnosed with bile acid diarrhea and are not currently using medications such as bile acid sequestrants or specific antibiotics.
As an unphased trial, this study provides a unique opportunity to explore a new dietary approach for symptom management.
Will I have to stop taking my current medications?
If you are taking bile acid sequestrants, you will need to stop one week before the study begins and not use them during the study. Also, you cannot use oral antibiotics or NSAIDs for two weeks before and during the study.
What prior data suggests that Hemp Hull WFI is safe for IBS diarrhea?
Research shows that hemp use usually doesn't cause stomach problems like diarrhea. Some studies suggest that hemp hull fiber might help with gut issues in people with IBS-related diarrhea. Although detailed safety information about Hemp Hull WFI is limited, the ongoing research into hemp hulls suggests they are generally considered safe. As this treatment involves a fiber supplement, it may be similar to other dietary fibers, which most people can usually tolerate easily.12345
Why are researchers excited about this trial?
Unlike standard treatments for IBS diarrhea, which often rely on medications that manage symptoms or alter gut motility, Hemp Hull WFI is derived from hemp hulls. This gives it a unique edge as it introduces a new, natural active ingredient that may offer a gentler alternative with potentially fewer side effects. Researchers are excited about this treatment because it introduces a novel dietary approach, using BB01 supplement bars, that could offer relief by supporting gut health in a holistic way. If effective, it might provide a more sustainable, lifestyle-friendly option for managing IBS symptoms.
What evidence suggests that Hemp Hull WFI might be an effective treatment for IBS diarrhea?
Research has shown that hemp hulls, rich in a type of fiber that doesn't dissolve in water, might help with diarrhea caused by IBS. A small study found that this fiber can reduce gut "leakiness," a common issue in IBS. This fiber adds bulk to stools and can regulate bowel movements, potentially easing diarrhea. Additionally, hemp extracts like CBD can interact with the gut to alter its movement, possibly aiding with diarrhea. These early findings suggest that hemp hulls could benefit people with IBS-related diarrhea. Participants in this trial will consume BB01 supplement bars containing Hemp Hull WFI to evaluate its effectiveness for IBS-related diarrhea.12678
Who Is on the Research Team?
Michael Camilleri, MD
Principal Investigator
Mayo Clinic
Are You a Good Fit for This Trial?
This trial is for individuals with IBS-diarrhea who have specific bile acid levels in their blood and stool, a BMI under 40, and haven't used antibiotics or NSAIDs recently. Those with certain surgeries like gallbladder removal can join, but not if they've had other bowel surgeries or take certain diabetes medications.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants consume two BB01 supplement bars daily for 21 days
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Hemp Hull WFI
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor