Sleep and Circadian Interventions for Suicide
(REST-UP Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this study is to examine the extent to which delivering sleep and circadian focused interventions in addition to evidenced based psychiatric care for depression and suicide risk may contribute to decreasing suicide risk among high risk young adults. Investigators will evaluate three interventions targeting sleep in acutely suicidal college students enrolled in intensive outpatient treatment. Participants will be randomly assigned to one of three intervention groups:
1. Triple Chronotherapy (TCT)+ Transdiagnostic Sleep and Circadian Intervention (TSC)
2. Transdiagnostic Sleep and Circadian Intervention (TSC)
3. Sleep Feedback (SF) Participants will be followed for 6 months with primary outcome domains of suicidal thoughts and behaviors and depression evaluated by blinded clinicians at short (Days 1-4 of intervention), medium (2 months) and long (6 month) term intervals.
Who Is on the Research Team?
Tina Goldstein, PhD
Principal Investigator
University of Pittsburgh
Peter Franzen
Principal Investigator
University of Pittsburgh
Are You a Good Fit for This Trial?
This trial is for college students at high risk of suicide who are fluent in English, have had suicidal thoughts or attempts in the past month, and suffer from significant sleep disturbances. They must be enrolled or planning to enroll in COSTAR Intensive Outpatient Program.Inclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Sleep Feedback + Psychoeducation
- Transdiagnostic Sleep and Circadian Intervention + Bright Light (TSC+)
- Triple Chronotherapy (TCT+)
Trial Overview
The study tests three interventions: Triple Chronotherapy plus Transdiagnostic Sleep and Circadian Intervention (TCT+TSC), just TSC, and Sleep Feedback. These are added to standard psychiatric care for depression/suicide risk to see if they lower suicide risk over a 6-month period.
How Is the Trial Designed?
3
Treatment groups
Experimental Treatment
TCT+ Participants receive a four-day intervention, beginning with an approximately 33-hour total sleep deprivation period, followed by 3-days of sleep phase advancement and daily bright light therapy (up to sixty minutes) in the morning and blue light blocking glasses (up to one hour before bedtime) in the evening, in a sleep lab. TSC+ Participants will also attend 6-8 TSC sessions of a manualized sleep intervention with a Sleep therapist, delivered in person or videoconference. Participants will continue to wear bright light glasses (up to sixty minutes daily) in the morning and blue light blocking glasses (up to one hour before bedtime) in the evening throughout the intervention. SF Participants receive an actigraphy watch to track their sleep and activity levels and complete a daily sleep diary; sleep feedback graphs show participants their actigraphy watch and sleep diary data on demand.
Participants will attend 6-8 TSC sessions of a manualized sleep intervention with a Sleep therapist, delivered in person or videoconference. Participants will also wear bright light glasses (up to 60 minutes) in the morning and blue light blocking glasses in the evening throughout the intervention. Additionally, participants receive an actigraphy watch to track their sleep and activity levels and complete a daily sleep diary; sleep feedback graphs show participants their actigraphy watch and sleep diary data on demand.
Participants receive an actigraphy watch to track their sleep and activity levels and complete a daily sleep diary; sleep feedback graphs show participants their actigraphy watch and sleep diary data on demand.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Pittsburgh
Lead Sponsor
American Foundation for Suicide Prevention
Collaborator
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