Imipramine Pamoate

Nocturnal Enuresis (bedwetting), Bulimia Nervosa, Panic Disorder + 3 more
Treatment
20 Active Studies for Imipramine Pamoate

What is Imipramine Pamoate

ImipramineThe Generic name of this drug
Treatment SummaryImipramine is a tricyclic antidepressant (TCA) used to treat depression. It works by blocking the reuptake of serotonin and norepinephrine, two neurotransmitters that regulate mood. It also blocks certain receptors in the body, which can lead to side effects such as sedation, low blood pressure, and blurred vision. Imipramine is also sometimes prescribed to treat conditions such as chronic pain, panic disorder, ADHD, and PTSD.
Tofranilis the brand name
image of different drug pills on a surface
Imipramine Pamoate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tofranil
Imipramine
1959
103

Effectiveness

How Imipramine Pamoate Affects PatientsImipramine is a type of antidepressant that helps to treat depression by increasing the levels of serotonin and norepinephrine, two chemicals in the brain that can affect mood. It is similar to other drugs such as amitriptyline and doxepin. When taken, imipramine can lead to changes in the brain such as increased production of nerve cells and reduced stress responses. It is believed that these changes, along with its effect on serotonin, are what make it an effective antidepressant. Additionally, it may cause a decrease in certain receptors in the brain that help to regulate adrenaline.
How Imipramine Pamoate works in the bodyImipramine helps treat depression by blocking the removal of two important neurotransmitters, norepinephrine and serotonin, from the spaces between neurons. This allows these two chemicals to stay in the spaces between neurons longer, stimulating the neurons and relieving symptoms of depression.

When to interrupt dosage

The recommended dosage of Imipramine Pamoate is contingent upon the diagnosed condition, such as Bedwetting, Bulimia Nervosa and Depression. The amount of dosage is dependent on the mode of administration (e.g. Tablet, sugar coated or Tablet, sugar coated - Oral), as indicated in the below table.
Condition
Dosage
Administration
Neuropathic Pain
10.0 mg, , 75.0 mg, 100.0 mg, 125.0 mg, 150.0 mg, 50.0 mg, 25.0 mg, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Intramuscular, Injection, solution, Injection, solution - Intramuscular
Nocturnal Enuresis (bedwetting)
10.0 mg, , 75.0 mg, 100.0 mg, 125.0 mg, 150.0 mg, 50.0 mg, 25.0 mg, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Intramuscular, Injection, solution, Injection, solution - Intramuscular
Bulimia Nervosa
10.0 mg, , 75.0 mg, 100.0 mg, 125.0 mg, 150.0 mg, 50.0 mg, 25.0 mg, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Intramuscular, Injection, solution, Injection, solution - Intramuscular
Panic Disorder
10.0 mg, , 75.0 mg, 100.0 mg, 125.0 mg, 150.0 mg, 50.0 mg, 25.0 mg, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Intramuscular, Injection, solution, Injection, solution - Intramuscular
Depression
10.0 mg, , 75.0 mg, 100.0 mg, 125.0 mg, 150.0 mg, 50.0 mg, 25.0 mg, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Intramuscular, Injection, solution, Injection, solution - Intramuscular
Attention Deficit Hyperactivity Disorder
10.0 mg, , 75.0 mg, 100.0 mg, 125.0 mg, 150.0 mg, 50.0 mg, 25.0 mg, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Intramuscular, Injection, solution, Injection, solution - Intramuscular

Warnings

Imipramine Pamoate has two contraindications and should not be concomitantly administered when afflicted with any of the conditions in the table below.Imipramine Pamoate Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Myocardial Infarction
Do Not Combine
There are 20 known major drug interactions with Imipramine Pamoate.
Common Imipramine Pamoate Drug Interactions
Drug Name
Risk Level
Description
Acepromazine
Major
Imipramine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Imipramine is combined with Aclidinium.
Alfuzosin
Major
Imipramine may increase the hypotensive activities of Alfuzosin.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Imipramine.
Amoxapine
Major
Imipramine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Amoxapine.
Imipramine Pamoate Toxicity & Overdose RiskTaking too much imipramine can cause dryness in the mouth and eyes, increased body temperature, constipation, difficulty urinating, tiredness, agitation, nightmares, confusion, decreased appetite, stomach pain, vomiting, and a strange taste in the mouth. In rare cases, it can lead to low blood cell counts and blood clotting problems. Infants born to mothers taking imipramine may experience heart problems, fussiness, breathing difficulty, muscle spasms, convulsions, and difficulty urinating. Taking it with other drugs that increase serotonin levels can cause serotonin syndrome. The LD50 for rats is 250mg/
image of a doctor in a lab doing drug, clinical research

Imipramine Pamoate Novel Uses: Which Conditions Have a Clinical Trial Featuring Imipramine Pamoate?

779 active clinical trials are currently assessing the potential of Imipramine Pamoate to provide relief from Attention Deficit Hyperactivity Disorder, Bulimia Nervosa and Depression.
Condition
Clinical Trials
Trial Phases
Attention Deficit Hyperactivity Disorder
65 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Phase 2, Phase 1, Early Phase 1
Nocturnal Enuresis (bedwetting)
1 Actively Recruiting
Not Applicable
Depression
337 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 4, Phase 3
Panic Disorder
9 Actively Recruiting
Not Applicable
Bulimia Nervosa
0 Actively Recruiting
Neuropathic Pain
5 Actively Recruiting
Not Applicable, Phase 1, Phase 2

Imipramine Pamoate Reviews: What are patients saying about Imipramine Pamoate?

4.3Patient Review
1/16/2014
Imipramine Pamoate for Depression
Imipramine has been extremely effective for me in treating my psychiatric problems. I've been taking it for most of my life, and the imipramine pamoate formulation seems to really help with side effects like tremor and dry mouth. The old tricyclic antidepressants have a similar effect to the newer SNRIs but are much cheaper, so Imipramine is a great option.
4.3Patient Review
11/19/2013
Imipramine Pamoate for Depression
The side effects of this medication were really terrible and it made my symptoms worse. I was stressed, agitated, and felt strung-out all the time. I took it for off-label use for ADHD and it is by far the worst medication I have ever taken.
2Patient Review
1/6/2011
Imipramine Pamoate for Depression
I took this medication for its side effect of causing sleep.
1Patient Review
7/1/2013
Imipramine Pamoate for Attention Deficit Disorder with Hyperactivity
Imipramine has helped me a lot with my incontinence issues.

Patient Q&A Section about imipramine pamoate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What class of drug is imipramine pamoate?

"Imipramine belongs to a class of antidepressants known as tricyclics. It treats depression by increasing the levels of certain chemicals in the brain that are necessary for mental balance."

Answered by AI

What is imipramine pamoate used for?

"This drug is given to people who are suffering from depression. It is thought to work by aiding in the regulation of moods, and may also help with sleep and appetite. It may also give the patient more energy to take part in daily activities. The drug imipramine pamoate is classified as a tricyclic antidepressant."

Answered by AI

What is the difference between Imipramine HCl and pamoate?

"Imipramine HCl is FDA approved for adults and adolescents with depression, as well as bedwetting in children. Imipramine pamoate is only approved to treat depression in adults ages 17 and up."

Answered by AI

Is imipramine used for anxiety?

"Imipramine is a drug that is used to treat depression, anxiety, and panic disorder. It belongs to a class of drugs called tricyclic antidepressants. It is often used to treat bedwetting in children, even though it is not clear how it prevents bedwetting."

Answered by AI

Clinical Trials for Imipramine Pamoate

Have you considered Imipramine Pamoate clinical trials? We made a collection of clinical trials featuring Imipramine Pamoate, we think they might fit your search criteria.
Have you considered Imipramine Pamoate clinical trials? We made a collection of clinical trials featuring Imipramine Pamoate, we think they might fit your search criteria.
Have you considered Imipramine Pamoate clinical trials? We made a collection of clinical trials featuring Imipramine Pamoate, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top