Trulance

Constipation-predominant Irritable Bowel Syndrome (IBS-C), chronic idiopathic constipation (CIC)
Treatment
7 Active Studies for Trulance

What is Trulance

PlecanatideThe Generic name of this drug
Treatment SummaryPlecanatide is a medication approved by the FDA in 2017 that can be used to treat chronic constipation in adults. It should not be used in children under the age of 6 and should be avoided in patients aged 6-18.
Trulance Immediate releaseis the brand name
image of different drug pills on a surface
Trulance Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Trulance Immediate release
Plecanatide
2017
2

Effectiveness

How Trulance Affects PatientsEating a meal with either low-fat or high-fat content can affect how well this drug works. People who ate and took the drug reported having looser stools than those who were fasting and took the drug. In clinical studies, the drug was tested with and without being taken with food.
How Trulance works in the bodyPlecanatide works by stimulating a molecule called Guanylate Cyclase C (GC-C). This triggers the release of chloride and bicarbonate into the intestines, which leads to increased fluid content and quicker movement of food through your digestive tract. This can help with symptoms of abdominal pain and discomfort. Plecanatide also helps make stool more consistent. The exact way it helps with pain is not yet known.

When to interrupt dosage

The measure of Trulance is contingent upon the diagnosed state. The dosage is likewise dependent on the technique of administration outlined in the table below.
Condition
Dosage
Administration
chronic idiopathic constipation (CIC)
, 3.0 mg
, Oral, Tablet, Tablet - Oral
Constipation-predominant Irritable Bowel Syndrome (IBS-C)
, 3.0 mg
, Oral, Tablet, Tablet - Oral

Warnings

Trulance has four contraindications and should not be taken when experiencing issues delineated in the table below.Trulance Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
suspected mechanical gastrointestinal obstruction
Do Not Combine
Mechanical Intestinal Obstruction
Do Not Combine
Pulse Frequency
Do Not Combine
There are 19 known major drug interactions with Trulance.
Common Trulance Drug Interactions
Drug Name
Risk Level
Description
Alloin
Minor
The risk or severity of adverse effects can be increased when Plecanatide is combined with Alloin.
Calcium polycarbophil
Minor
The risk or severity of adverse effects can be increased when Plecanatide is combined with Calcium polycarbophil.
Deacetylbisacodyl
Minor
The risk or severity of adverse effects can be increased when Plecanatide is combined with Deacetylbisacodyl.
Frangula purshiana bark
Minor
The risk or severity of adverse effects can be increased when Plecanatide is combined with Frangula purshiana bark.
Konjac mannan
Minor
The risk or severity of adverse effects can be increased when Plecanatide is combined with Konjac mannan.
Trulance Toxicity & Overdose RiskA high dose of plecanatide can be fatal for young mice as young as one month old, with a dose of 0.5 mg/kg causing death within 7 days and 10 mg/kg causing death within 14 days.
image of a doctor in a lab doing drug, clinical research

Trulance Novel Uses: Which Conditions Have a Clinical Trial Featuring Trulance?

An active study is currently assessing the potential of Trulance for use in the management of chronic idiopathic constipation (CIC).
Condition
Clinical Trials
Trial Phases
Constipation-predominant Irritable Bowel Syndrome (IBS-C)
6 Actively Recruiting
Phase 3, Phase 2, Not Applicable
chronic idiopathic constipation (CIC)
1 Actively Recruiting
Phase 2, Phase 3

Trulance Reviews: What are patients saying about Trulance?

5Patient Review
4/23/2022
Trulance for Irritable Bowel Syndrome with Constipation
Trulance has been an absolute godsend for me. I've had a lifelong battle with constipation, but this medication really works. Within 20 minutes of taking it (with 20oz of water), I have a bowel movement. It's been such a relief to finally find something that works!
4.7Patient Review
6/22/2022
Trulance for Irritable Bowel Syndrome with Constipation
I was given some of these by my doctor to try out, and I found that a very small dosage does the trick in terms of moving my bowels. I take it every other day after lunch, and it works within a few hours. The only downside is that I need to drink more water or else get headaches, but that's not too big of a deal for me.
4.7Patient Review
8/24/2022
Trulance for Chronic Difficulty having a Bowel Movement
As others have said, this medication can cause explosive diarrhea. However, it is very effective, working within two hours or so. Just be sure to not make any plans until it's done its job! I've found it to be much better than anything else I've tried; before Trulance, I was having to use 10 Ducolax pills at a time!
4.7Patient Review
5/5/2022
Trulance for Irritable Bowel Syndrome with Constipation
So far, this has been more effective than both Amitiza and Linzess. No diarrhea or other movement issues yet, but it's only been a week.
4.3Patient Review
7/19/2022
Trulance for Irritable Bowel Syndrome with Constipation
I've been struggling to have regular bowel movements for months, trying different treatments with little success. However, this treatment finally did the trick! I take it every night before bed and add chia seeds to my diet during the day, which has helped immensely. So if you're struggling like I was, don't give up hope—this treatment could work for you too.
3.7Patient Review
8/10/2022
Trulance for Irritable Bowel Syndrome with Constipation
It was a little scary 1st 2d. Told to take at night with Myralax. Mess all of bed more than 3x's each night. Prefer to take during the day. But after 5wks, I am taking twice the dose & it's not doing anything. Type 1 diabetic with vagus nerve neuropathy. Will have to be on a liquid diet if I dont get some sort of help
3.7Patient Review
6/3/2022
Trulance for Chronic Difficulty having a Bowel Movement
I started seeing results within an hour of taking the medication. However, these results were watery and explosive diarrhea that lasted for six hours straight. It was very difficult to manage during this time.
3Patient Review
8/8/2022
Trulance for Irritable Bowel Syndrome with Constipation
Trulance may cause you to lose control of your bowels. Be careful when taking this drug and be sure to stay close to a bathroom.
2.7Patient Review
11/8/2022
Trulance for Irritable Bowel Syndrome with Constipation
I felt really bad after taking this medication. I was dizzy, anxious, and bloated. After a short while, I started feeling nauseous and ended up having to run to the bathroom multiple times. This medication should be sold to people who want to get revenge on their cheating partners.
2.3Patient Review
8/27/2020
Trulance for Irritable Bowel Syndrome with Constipation
I didn't find this treatment to be very effective. It gives me explosive diarrhea and bloating within an hour of taking it, and I usually have to use Miralax as well. Then I'm still feeling bloated after that and often uncomfortable overnight.
2.3Patient Review
10/24/2022
Trulance for Irritable Bowel Syndrome with Constipation
I've been taking this medication for about a week and a half now, and I'm still not seeing results. I'm bloated, have gas and cramping, but no bowel movement. I've tried everything else I can think of, but nothing is working. I'll mention it to my doctor at my next visit, but I'm not sure what the next step is.
2.3Patient Review
10/14/2022
Trulance for Irritable Bowel Syndrome with Constipation
I've tried a lot of different treatments, but this is the first one that's given me any relief. It works quickly, but the discomfort it causes is really intense. I'm not sure if it's worth it yet.
2Patient Review
3/30/2022
Trulance for Irritable Bowel Syndrome with Constipation
I had terrible diarrhea within an hour of taking this pill. My stomach was making incredibly loud noises and I felt awful. I will never take this again.
2Patient Review
12/18/2021
Trulance for Irritable Bowel Syndrome with Constipation
This medication gave me such severe diarrhea that I had to wear diapers. It also dehydrated me and caused dizziness and brain fog the next day.
1.7Patient Review
6/8/2022
Trulance for Irritable Bowel Syndrome with Constipation
The diarrhea and stomach pain continue for several hours after taking the medication. I stopped taking it a couple days after starting because consulting my doctor. The medicine is worse than the condition it is supposed to help.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about trulance

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Trulance good for constipation?

"Trulance works by increasing the natural movement of your digestive system.

Trulance is a prescription medicine used in adults to treat Irritable Bowel Syndrome with Constipation (IBS-C) and Chronic Idiopathic Constipation (CIC). Trulance works by increasing the natural movement of your digestive system."

Answered by AI

What are the side effects for Trulance?

"Abdominal pain, tenderness, and bloating, as well as increased gas and liver biochemical tests, are associated with severe sinus infections, upper respiratory tract infections, and diarrhea."

Answered by AI

Should I take Trulance in the morning or at night?

"There is no specific time of day that Trulance needs to be taken, and it can be done either with or without food. There is also no need to plan activities around the medication."

Answered by AI

How long after taking Trulance Will I have a bowel movement?

"With mild diarrhea, you may have other symptoms such as loose stools, abdominal pain, bloating, or cramps. In clinical trials, mild diarrhea typically happened within the first 4 weeks of starting Trulance treatment."

Answered by AI

Clinical Trials for Trulance

Have you considered Trulance clinical trials? We made a collection of clinical trials featuring Trulance, we think they might fit your search criteria.