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What is Sporanox
ItraconazoleThe Generic name of this drug
Treatment SummaryItraconazole is an antifungal medication that stops the growth of fungi by preventing the production of a necessary component called ergosterol. This drug is used to treat infections like histoplasmosis, blastomycosis, cryptococcal meningitis, and aspergillosis.
Sporanoxis the brand name
Sporanox Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Sporanox
Itraconazole
1992
35
Approved as Treatment by the FDA
Itraconazole, otherwise known as Sporanox, is approved by the FDA for 6 uses which include Cellulitis and Esophageal Candidiasis .Cellulitis
Esophageal Candidiasis
Sporotrichosis
Oropharyngeal Candidiasis
Chromoblastomycosis
Paracoccidioidomycosis
Effectiveness
How Sporanox Affects PatientsItraconazole is a medication used to treat fungal infections. It works by stopping the growth of certain types of fungus by blocking the enzymes that create the cell walls. Itraconazole has been shown to be effective against Cryptococcus neoformans and Candida spp. in both normal and immunocompromised animals. It has also been used to treat systemic and intracranial fungal infections due to Cryptococcus neoformans and systemic infections due to Candida albicans.
How Sporanox works in the bodyItraconazole works by targeting an enzyme that helps build the fungal cell membrane. By blocking this enzyme, itraconazole causes the cell membrane to become leaky, allowing its contents to escape. Itraconazole has other effects as well, such as blocking respiration, preventing fungi from changing their shape, and interfering with the production of fats and lipids.
When to interrupt dosage
The endorsed dose of Sporanox is contingent upon the diagnosed disorder, including Onychomycosis, prophylaxis of Penicilliosis and Coccidioidal meningitis. The measure of dosage fluctuates, according to the administration technique delineated in the table below.Condition
Dosage
Administration
Esophageal Candidiasis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Coccidioidal meningitis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Onychomycosis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
disseminated Other specified protozoal diseases
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Vulvovaginal Candidiasis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Penicillium marneffei infection
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Coccidioides
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Blastomycosis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Sporotrichosis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
prophylaxis of Histoplasmosis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Chromoblastomycosis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Paracoccidioidomycosis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
HIV
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Oropharyngeal Candidiasis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Histoplasmosis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Cellulitis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
prophylaxis of Penicilliosis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Aspergillosis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Warnings
Sporanox has four contraindications and should not be amalgamated with the conditions specified in the following table.Sporanox ContraindicationsCondition
Risk Level
Notes
Congestive Heart Failure
Do Not Combine
Congestive heart failure
Do Not Combine
Cytochrome P450
Do Not Combine
suspected pregnancy
Do Not Combine
Common Sporanox Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Major
The metabolism of (R)-warfarin can be decreased when combined with Itraconazole.
(S)-Warfarin
Major
The metabolism of (S)-Warfarin can be decreased when combined with Itraconazole.
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be decreased when combined with Itraconazole.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Itraconazole.
5-androstenedione
Major
The metabolism of 5-androstenedione can be decreased when combined with Itraconazole.
Sporanox Toxicity & Overdose RiskNo life-threatening reactions were seen in mice, rats, and dogs when itraconazole was administered orally at doses of 320mg/kg and 200mg/kg respectively.
Sporanox Novel Uses: Which Conditions Have a Clinical Trial Featuring Sporanox?
137 active clinical trials are being conducted to explore the potential of Sporanox in managing Chromomycosis, Dermatomycoses and Sporotrichosis.Condition
Clinical Trials
Trial Phases
HIV
146 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1
Paracoccidioidomycosis
0 Actively Recruiting
Vulvovaginal Candidiasis
0 Actively Recruiting
Esophageal Candidiasis
0 Actively Recruiting
Histoplasmosis
1 Actively Recruiting
Phase 1, Phase 2
Onychomycosis
4 Actively Recruiting
Phase 2, Not Applicable, Phase 1
Oropharyngeal Candidiasis
0 Actively Recruiting
prophylaxis of Histoplasmosis
0 Actively Recruiting
Chromoblastomycosis
0 Actively Recruiting
Coccidioidal meningitis
0 Actively Recruiting
disseminated Other specified protozoal diseases
0 Actively Recruiting
Aspergillosis
2 Actively Recruiting
Phase 3
Penicillium marneffei infection
0 Actively Recruiting
Blastomycosis
0 Actively Recruiting
Coccidioides
0 Actively Recruiting
Sporotrichosis
0 Actively Recruiting
Cellulitis
0 Actively Recruiting
prophylaxis of Penicilliosis
0 Actively Recruiting
Sporanox Reviews: What are patients saying about Sporanox?
5Patient Review
10/28/20073.7Patient Review
6/29/2009 I was diagnosed with histoplasmosis in my lungs in May 2007 after several trips to the hospital. Sporonox worked but the side effects got worse at first, with pain then nightmares. Now I experience fatigue, trouble sleeping and loss of interest.
3.7Patient Review
10/27/2010 I am taking this medication to combat a fungal infection in my lungs, and it seems to be working well so far. I have not experienced any of the listed side effects, which is great. The only downside is that it doesn't taste very good.
3.7Patient Review
1/30/2014 Sporanox has been an effective treatment for me, though I have had to take it on and off for six years now. Every time I stop taking it, the sinus fungal symptoms come back. I am worried about potential liver and heart issues, but my doctors keep a check on me.
3.7Patient Review
9/1/2009 It's been quite a while since I first started this treatment, and the infection still hasn't cleared up. That said, it has significantly improved. I'm hopeful that with more time it will be gone entirely.
3.7Patient Review
5/14/2009 This medication is effective, but very inconvenient to take. I have to time it around my other medications and can't have anything else to drink for an hour afterwards, which makes it difficult to work into my schedule.
3Patient Review
10/30/2008 The taste is really awful, but it works.
1.7Patient Review
3/16/2014 I found this treatment to be more harmful than helpful.
1Patient Review
11/30/2012 I was given this drug to treat a fingernail fungus contacted from a nail salon. I took the medicine before going to bed and was awakened a few hours later with severe itching. When I went into my bathroom and turned on the light, I could not believe the swelling and redness. I had red hives from the top of my head to the soles of my feet.
Patient Q&A Section about sporanox
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Which is better Sporanox or Lamisil?
"The LION study showed that terbinafine was more effective than itraconazole in treating onychomycosis."
Answered by AI
What are the side effects of the drug Sporanox?
", feeling anxious, nervous, or irritable
headache, increased blood pressure, rash, itching, nausea, vomiting, stomach pain, diarrhea, constipation, swelling, abnormal liver function or blood tests, fever, muscle or joint pain, unusual or unpleasant taste in your mouth, feeling anxious, nervous, or irritable"
Answered by AI
What is Sporanox used for?
"The Sporanox capsule is used to treat fungal infections in fingernails or toenails, while the Itraconazole tablet is only used to treat toenail fungal infections. This medicine kills the fungus or yeast and prevents its growth. You need a doctor's prescription to get this medicine."
Answered by AI
How long does it take Sporanox to work?
"It may take up to 6 months to grow a new fingernail, and up to 12 months to grow a new toenail. Therefore, you should not expect to see an improvement during your treatment, or for several months afterward. It is important to continue taking itraconazole even if you do not see any improvement."
Answered by AI