Streptomycin Sulfate

Plague, Chancroid, Tularemia + 13 more
Treatment
10 FDA approvals
20 Active Studies for Streptomycin Sulfate

What is Streptomycin Sulfate

StreptomycinThe Generic name of this drug
Treatment SummaryStreptomycin is an antibiotic made from a soil bacterium called Streptomyces griseus. It was discovered in the 1940s and its antibacterial effects earned its discoverers the Nobel Prize in Medicine. While it was once commonly used to treat tuberculosis, its use has since declined due to the development of resistance. It is now mainly used as a secondary treatment for multi-drug resistant tuberculosis.
Streptomycin Sulfateis the brand name
image of different drug pills on a surface
Streptomycin Sulfate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Streptomycin Sulfate
Streptomycin
1952
2

Approved as Treatment by the FDA

Streptomycin, otherwise called Streptomycin Sulfate, is approved by the FDA for 10 uses which include Granuloma Inguinale and Chancroid .
Granuloma Inguinale
Chancroid
Plague
Bacteremia
Tularemia
Bacterial Infections caused by susceptible bacteria
Urinary Tract Infection
Pneumonia
Influenza
Tuberculosis (TB)
Used to treat Tuberculosis (TB) in combination with Isoniazid

Effectiveness

How Streptomycin Sulfate Affects PatientsStreptomycin is an antibiotic that is used to treat certain bacteria, including Yersinia pestis, Francisella tularensis, Brucella, H. ducreyi, and H. influenza. It is less effective against the bacteria Pseudomonas aeruginosa. Taking streptomycin may lead to hearing loss and vestibular dysfunction, as well as kidney and muscle damage. People taking this drug should be watched carefully for signs of these side effects.
How Streptomycin Sulfate works in the bodyAminoglycosides work to kill bacteria in two ways. First, they bind to bacterial cell membranes, creating holes in and damaging them. This immediately kills the bacteria. Second, they bind to the bacteria's ribosomes and stop proteins from being produced correctly. This eventually leads to the bacteria dying, but takes longer. The aminoglycosides bind to two sites on the ribosome - one near the A site, and one near the 23S rRNA - and stop it from making proteins correctly. As a result, incorrect proteins are made and the cell membrane is damaged, which eventually kills the bacteria.

When to interrupt dosage

The advised dosage of Streptomycin Sulfate is subject to the diagnosed condition, including Tuberculosis (TB), Influenza and Plague. The measure of dosage fluctuates as detailed in the table below, contingent upon the technique of administration (e.g. Liquid - Intramuscular or Liquid).
Condition
Dosage
Administration
Plague
1000.0 mg, , 1000.0 mg/mL
, Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Liquid - Intramuscular, Liquid, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Injection, solution, Injection, solution - Intramuscular
Mycobacterium kansasii infection
1000.0 mg, , 1000.0 mg/mL
, Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Liquid - Intramuscular, Liquid, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Injection, solution, Injection, solution - Intramuscular
Mycobacterium avium complex infection
1000.0 mg, , 1000.0 mg/mL
, Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Liquid - Intramuscular, Liquid, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Injection, solution, Injection, solution - Intramuscular
Bacteremia
1000.0 mg, , 1000.0 mg/mL
, Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Liquid - Intramuscular, Liquid, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Injection, solution, Injection, solution - Intramuscular
Mycobacterium marinum infection
1000.0 mg, , 1000.0 mg/mL
, Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Liquid - Intramuscular, Liquid, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Injection, solution, Injection, solution - Intramuscular
Pneumonia
1000.0 mg, , 1000.0 mg/mL
, Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Liquid - Intramuscular, Liquid, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Injection, solution, Injection, solution - Intramuscular
HIV
1000.0 mg, , 1000.0 mg/mL
, Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Liquid - Intramuscular, Liquid, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Injection, solution, Injection, solution - Intramuscular
Influenza
1000.0 mg, , 1000.0 mg/mL
, Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Liquid - Intramuscular, Liquid, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Injection, solution, Injection, solution - Intramuscular
Acrodynia
1000.0 mg, , 1000.0 mg/mL
, Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Liquid - Intramuscular, Liquid, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Injection, solution, Injection, solution - Intramuscular
Tuberculosis (TB)
1000.0 mg, , 1000.0 mg/mL
, Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Liquid - Intramuscular, Liquid, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Injection, solution, Injection, solution - Intramuscular
Disseminated mycobacterium avium complex infection
1000.0 mg, , 1000.0 mg/mL
, Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Liquid - Intramuscular, Liquid, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Injection, solution, Injection, solution - Intramuscular
Bacterial Infections caused by susceptible bacteria
1000.0 mg, , 1000.0 mg/mL
, Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Liquid - Intramuscular, Liquid, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Injection, solution, Injection, solution - Intramuscular
Granuloma Inguinale
1000.0 mg, , 1000.0 mg/mL
, Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Liquid - Intramuscular, Liquid, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Injection, solution, Injection, solution - Intramuscular
Chancroid
1000.0 mg, , 1000.0 mg/mL
, Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Liquid - Intramuscular, Liquid, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Injection, solution, Injection, solution - Intramuscular
Tularemia
1000.0 mg, , 1000.0 mg/mL
, Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Liquid - Intramuscular, Liquid, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Injection, solution, Injection, solution - Intramuscular
Urinary Tract Infection
1000.0 mg, , 1000.0 mg/mL
, Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Liquid - Intramuscular, Liquid, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Injection, solution, Injection, solution - Intramuscular

Warnings

Streptomycin Sulfate has two contraindications and must not be taken in coalition with the disorders specified in the table below.Streptomycin Sulfate Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Streptomycin may interact with Pulse Frequency
There are 20 known major drug interactions with Streptomycin Sulfate.
Common Streptomycin Sulfate Drug Interactions
Drug Name
Risk Level
Description
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Streptomycin is combined with Neomycin.
Tenofovir
Major
Streptomycin may increase the nephrotoxic activities of Tenofovir.
Tenofovir alafenamide
Major
Streptomycin may increase the nephrotoxic activities of Tenofovir alafenamide.
Tenofovir disoproxil
Major
Streptomycin may increase the nephrotoxic activities of Tenofovir disoproxil.
Vibrio cholerae CVD 103-HgR strain live antigen
Major
The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Streptomycin.
Streptomycin Sulfate Toxicity & Overdose RiskOverdosing on streptomycin can lead to hearing or balance problems, as well as kidney damage. Symptoms of kidney damage may range from mild, such as increased levels of urea in the blood and protein in the urine, to more severe cases of permanent hearing loss and vestibular dysfunction. If a patient has overdosed on streptomycin, their serum concentration can be reduced through dialysis.
image of a doctor in a lab doing drug, clinical research

Streptomycin Sulfate Novel Uses: Which Conditions Have a Clinical Trial Featuring Streptomycin Sulfate?

244 active clinical trials are presently studying the potential of Streptomycin Sulfate in combating Bacterial Infections caused by susceptible bacteria, Mycobacterium avium complex infection and Granuloma Inguinale.
Condition
Clinical Trials
Trial Phases
Bacteremia
13 Actively Recruiting
Not Applicable, Phase 4, Phase 1, Phase 2
Tularemia
0 Actively Recruiting
Bacterial Infections caused by susceptible bacteria
0 Actively Recruiting
Mycobacterium marinum infection
0 Actively Recruiting
Granuloma Inguinale
0 Actively Recruiting
Tuberculosis (TB)
3 Actively Recruiting
Not Applicable, Phase 3, Phase 2
Mycobacterium avium complex infection
3 Actively Recruiting
Phase 2, Phase 3
Mycobacterium kansasii infection
0 Actively Recruiting
Chancroid
0 Actively Recruiting
Acrodynia
1 Actively Recruiting
Phase 2
Influenza
29 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 3, Phase 1
Urinary Tract Infection
10 Actively Recruiting
Not Applicable, Phase 4, Phase 3
Disseminated mycobacterium avium complex infection
0 Actively Recruiting
Plague
0 Actively Recruiting
Pneumonia
62 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Early Phase 1, Phase 4
HIV
144 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1

Patient Q&A Section about streptomycin sulfate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is streptomycin sulfate the same as streptomycin?

"The sulfate salt form of streptomycin is an aminoglycoside antibiotic that is derived from Streptomyces griseus and has antibacterial properties."

Answered by AI

What type of antibiotic is streptomycin?

"Streptomycin is an aminoglycoside antibiotic that was first isolated from the bacteria Streptomyces griseus. It is now primarily used as part of the multi-drug treatment of pulmonary tuberculosis. It has additional activity against several aerobic gram-negative bacteria."

Answered by AI

What is streptomycin sulfate used for?

"This antibiotic is used to treat certain types of bacterial infections, however it will not work against infections like colds or the flu. If you have any questions about other purposes for this medicine, ask your health care provider or pharmacist."

Answered by AI

What bacteria is killed by streptomycin?

"Streptomycin is a medication used to treat bacterial infections, including tuberculosis, Mycobacterium avium complex, endocarditis, brucellosis, Burkholderia infection, plague, tularemia, and rat bite fever."

Answered by AI

Clinical Trials for Streptomycin Sulfate

Have you considered Streptomycin Sulfate clinical trials? We made a collection of clinical trials featuring Streptomycin Sulfate, we think they might fit your search criteria.
Have you considered Streptomycin Sulfate clinical trials? We made a collection of clinical trials featuring Streptomycin Sulfate, we think they might fit your search criteria.
Have you considered Streptomycin Sulfate clinical trials? We made a collection of clinical trials featuring Streptomycin Sulfate, we think they might fit your search criteria.