Nikki

Birth Control, Acne Vulgaris, Folate supplementation therapy + 9 more
Treatment
20 Active Studies for Nikki

What is Nikki

DrospirenoneThe Generic name of this drug
Treatment SummaryDrospirenone is a synthetic hormone found in some birth control pills, such as Yaz. It is also used to treat hormonal issues, such as acne and PMDD. While there have been some concerns about an increased risk of blood clots with drospirenone, the FDA has concluded that this risk is still lower than the risk during pregnancy and postpartum.
Yasminis the brand name
image of different drug pills on a surface
Nikki Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Yasmin
Drospirenone
2001
64

Effectiveness

How Nikki Affects PatientsDrospirenone is a contraceptive drug that stops ovulation, preventing pregnancy. It also helps to reduce acne and hirsutism. When taken with ethinyl estradiol, it can also help improve certain blood fats. In comparison to other progesterone contraceptives, drospirenone is thought to cause fewer side effects such as breast tenderness and mood swings. However, drospirenone use is associated with an increased risk of blood clots, especially for smokers and women over 35. Additionally, drospirenone may cause a condition called hyperkalemia, which can be dangerous. People at high risk for hyper
How Nikki works in the bodyDrospirenone and ethinyl estradiol work together to prevent pregnancy. They stop the body from releasing hormones that cause ovulation and make changes to the cervical mucus that keep sperm from reaching the egg. Drospirenone is similar to a diuretic, so it makes the body get rid of more sodium and water. It also blocks the effects of androgens, which are hormones that can cause acne and unwanted hair growth. Finally, drospirenone may reduce the amount of swelling in the sebaceous follicles that causes acne during the second half of the menstrual cycle.

When to interrupt dosage

The amount of Nikki is contingent upon the diagnosed affliction, such as moderate to severe symptoms, Menopause and Post-Menarche. The measure of dosage fluctuates in connection to the mode of delivery (e.g. Tablet, film coated - Oral or Oral) shown in the table underneath.
Condition
Dosage
Administration
N-Cadherins
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Hormonal Contraception
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
moderate to severe symptoms
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Birth Control
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Vasomotor System
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Acne Vulgaris
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Adherence to Oral Contraceptive Therapy
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Atrophic
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Post-Menarche
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Atrophy of vulva
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Folate supplementation therapy
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Hot flashes
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet

Warnings

Nikki Contraindications
Condition
Risk Level
Notes
Chronic Kidney Disease
Do Not Combine
Venous Thrombosis
Do Not Combine
Neoplasms, Hormone-Dependent
Do Not Combine
Migraine with Aura
Do Not Combine
Porphyrias
Do Not Combine
Breast
Do Not Combine
suspected pregnancy
Do Not Combine
Breast Milk Production
Do Not Combine
Metrorrhagia
Do Not Combine
Hypersensitivity
Do Not Combine
Liver Failure, Acute
Do Not Combine
Acute Kidney Injury
Do Not Combine
Deep Vein Thrombosis (DVT)
Do Not Combine
Vision Loss
Do Not Combine
Endometrial Hyperplasia
Do Not Combine
Tobacco Use
Do Not Combine
Liver Function Tests
Do Not Combine
Thrombophilia
Do Not Combine
Thromboembolism
Do Not Combine
high risk of arterial thrombotic disease
Do Not Combine
estrogen-dependent neoplasia
Do Not Combine
Liver Neoplasms
Do Not Combine
Adrenal Insufficiency
Do Not Combine
Thrombosis
Do Not Combine
Breast
Do Not Combine
estrogen-dependent neoplasia
Do Not Combine
There are 20 known major drug interactions with Nikki.
Common Nikki Drug Interactions
Drug Name
Risk Level
Description
Tranexamic acid
Major
Drospirenone may increase the thrombogenic activities of Tranexamic acid.
Acetohexamide
Minor
The therapeutic efficacy of Acetohexamide can be decreased when used in combination with Drospirenone.
Agmatine
Minor
The risk or severity of hyperkalemia can be increased when Drospirenone is combined with Agmatine.
Aliskiren
Minor
The risk or severity of hyperkalemia can be increased when Drospirenone is combined with Aliskiren.
Anisodamine
Minor
The risk or severity of hyperkalemia can be increased when Drospirenone is combined with Anisodamine.
Nikki Toxicity & Overdose RiskThe lowest toxic dose of drospirenone in rats has been found to be greater than 2000mg/kg. Those who overdose on drospirenone may experience nausea or bleeding, and may also have changes in their levels of sodium and potassium that should be monitored. Acidosis and high potassium levels may also occur as a result of an overdose.
image of a doctor in a lab doing drug, clinical research

Nikki Novel Uses: Which Conditions Have a Clinical Trial Featuring Nikki?

At present, 104 active studies are being conducted to analyze the utility of Nikki in treating Acne Vulgaris, Post-Menarcheal states and N-Cadherin-related disorders.
Condition
Clinical Trials
Trial Phases
N-Cadherins
1 Actively Recruiting
Phase 1
moderate to severe symptoms
0 Actively Recruiting
Folate supplementation therapy
0 Actively Recruiting
Acne Vulgaris
0 Actively Recruiting
Atrophy of vulva
1 Actively Recruiting
Not Applicable
Hormonal Contraception
0 Actively Recruiting
Hot flashes
16 Actively Recruiting
Phase 1, Phase 4, Not Applicable, Early Phase 1, Phase 2
Post-Menarche
0 Actively Recruiting
Adherence to Oral Contraceptive Therapy
0 Actively Recruiting
Birth Control
24 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Early Phase 1
Atrophic
3 Actively Recruiting
Phase 4, Not Applicable
Vasomotor System
0 Actively Recruiting

Nikki Reviews: What are patients saying about Nikki?

5Patient Review
1/14/2019
Nikki for Birth Control
4.3Patient Review
6/18/2022
Nikki for Premenstrual Disorder with a State of Unhappiness
Nikki has been a total game-changer for me. I had awful PMDD and my periods were so heavy, it would completely drain me. Now, I only have the occasional breakthrough spotting and my mood has dramatically improved. Instead of 10 days of PMS, I now only have a few days. Plus, my periods are much lighter now. Overall, I'm really satisfied with this medication.
3.7Patient Review
3/24/2019
Nikki for Birth Control
I took this medication for three weeks and started experiencing a whole host of negative side effects, including nausea, loss of appetite, constipation, and then skin sensitivity. My complexion became really inflamed and I was constantly itch. I had to stop taking the medication after that.
2.3Patient Review
2/11/2020
Nikki for Acne
I had to switch from Gianvi to Nikki at the pharmacy, and it was honestly a terrible experience. Not only did I get really bad acne, but I also experienced severe pigmentation that turned my palms dark brown. This pill is a nightmare and I would not recommend it to anyone.
2.3Patient Review
3/7/2019
Nikki for Birth Control
I've had no issues with Yaz, Gianvi, and Loryna. However, Nikki (from a different prescription service) gave me more break outs, greasy hair (which I've never had my entire life), and just an overall difference in mood/menstruation during my time of the month.
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about nikki

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who is blood and Nikki?

"Vlad and Niki are two American brothers who run a YouTube channel. Their parents are from Moscow, Russia, and they have a total of 21 channels in 18 different languages."

Answered by AI

Is Nikki Bella a twin?

"The Bella Twins were a professional wrestling tag team who performed on WWE and consisted of identical twin sisters Brie Bella and Nikki Bella (real names Brianna and Nicole). Each of the Bella Sisters is a former WWE Divas Champion. Brie is the first twin in WWE history to win that title."

Answered by AI

Clinical Trials for Nikki

Have you considered Nikki clinical trials? We made a collection of clinical trials featuring Nikki, we think they might fit your search criteria.
Have you considered Nikki clinical trials? We made a collection of clinical trials featuring Nikki, we think they might fit your search criteria.
Have you considered Nikki clinical trials? We made a collection of clinical trials featuring Nikki, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top