Liletta

Endometrial Hyperplasia, Endometriosis, Hot flashes + 6 more
Treatment
7 FDA approvals
20 Active Studies for Liletta

What is Liletta

LevonorgestrelThe Generic name of this drug
Treatment SummaryLevonorgestrel (LNG) is a synthetic hormone similar to progesterone used in contraception and hormone therapy. Commonly known as Plan B, it is used as a single dose emergency contraceptive and as a hormone released from an intrauterine device (IUD). A subdermal implant of levonorgestrel is also available, which slowly releases the hormone over a long period. Additionally, levonorgestrel is used as a component of combination contraceptives. Levonorgestrel is the most widely used emergency contraceptive and was approved by the FDA in 1982. It is effective and does not have the same estrogen
Triphasil-21is the brand name
image of different drug pills on a surface
Liletta Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Triphasil-21
Levonorgestrel
1984
243

Approved as Treatment by the FDA

Levonorgestrel, also known as Triphasil-21, is approved by the FDA for 7 uses including Osteoporosis, Postmenopausal and Postmenopausal Osteoporosis .
Osteoporosis, Postmenopausal
Used to treat Postmenopausal Osteoporosis in combination with Estradiol
Postmenopausal Osteoporosis
Used to treat Postmenopausal Osteoporosis in combination with Estradiol
moderate Menopausal Vasomotor Symptoms
Used to treat moderate Menopausal Vasomotor Symptoms in combination with Estradiol
Menopause
Used to treat severe Vasomotor Symptoms Associated With Menopause in combination with Estradiol
Has had at least 1 child
Emergency Contraception
Hot flashes
Used to treat Menopause in combination with Estradiol

Effectiveness

How Liletta Affects PatientsLevonorgestrel is a medication used as an emergency contraceptive to prevent pregnancy. It works by stopping ovulation, fertilization, and implantation up to 72 hours after sex. When used correctly, it is 89% effective in preventing pregnancy. When used as a hormone therapy, it helps prevent endometrial cancer caused by unopposed estrogen. Levonorgestrel implanted in the body, like an IUD, can be more than 99% effective at preventing pregnancy.
How Liletta works in the bodyLevonorgestrel works in several ways to prevent pregnancy. It suppresses the release of hormones that trigger ovulation, making it harder for an egg to be released. It also thickens cervical mucus, making it harder for sperm to move through and reach an egg. Levonorgestrel may also make it harder for a fertilized egg to attach to the uterus. Finally, when taken with estrogens, levonorgestrel helps lower the risk of endometrial cancer.

When to interrupt dosage

The prescribed dosage of Liletta is contingent upon the diagnosed condition, such as Endometrial Hyperplasia, Emergency Contraception and Hypermenorrhea. The magnitude of dosage is contingent on the administration method featured in the given table.
Condition
Dosage
Administration
Hot flashes
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Osteoporosis, Postmenopausal
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
moderate Menopausal Vasomotor Symptoms
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Endometrial Hyperplasia
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Endometriosis
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Emergency Contraception
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Menorrhagia
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Has had at least 1 child
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Menopause
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral

Warnings

Liletta Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Levonorgestrel may interact with Pulse Frequency
Abortion, Septic
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
Abortion, Spontaneous
Do Not Combine
HCG elevated
Do Not Combine
Pelvic Infection
Do Not Combine
Vaginitis
Do Not Combine
Acute Coryza
Do Not Combine
Breast Neoplasms
Do Not Combine
Uterine Cervicitis
Do Not Combine
Communicable Diseases
Do Not Combine
Gonorrhea
Do Not Combine
Breast Cancer
Do Not Combine
Intrauterine Devices
Do Not Combine
Liver Neoplasms
Do Not Combine
congenital or aquired uterine abnormality
Do Not Combine
Chlamydia Infections
Do Not Combine
Hypersensitivity
Do Not Combine
Emergency Contraception
Do Not Combine
Endocarditis, Bacterial
Do Not Combine
Vaginosis, Bacterial
Do Not Combine
suspected pregnancy
Do Not Combine
Uterine Cervicitis
Do Not Combine
Uterine Neoplasms
Do Not Combine
Pelvic Inflammatory Disease
Do Not Combine
Breast Neoplasms
Do Not Combine
Uterine Cervical Neoplasms
Do Not Combine
Fibroid Tumor
Do Not Combine
Endometritis
Do Not Combine
chlamydial cervical infection
Do Not Combine
PAP Test Abnormalities
Do Not Combine
Liver Failure, Acute
Do Not Combine
Uterine anomaly distorting uterine cavity
Do Not Combine
Breast Cancer
Do Not Combine
Cervical Dysplasia
Do Not Combine
Thromboembolism
Do Not Combine
Bacterial Vaginosis
Do Not Combine
Pelvic Inflammatory Disease
Do Not Combine
Breast
Do Not Combine
Vaginal Bleeding
Do Not Combine
Bacterial Vaginosis
Do Not Combine
Pelvic Inflammatory Disease
Do Not Combine
Gonorrhea
Do Not Combine
There are 20 known major drug interactions with Liletta.
Common Liletta Drug Interactions
Drug Name
Risk Level
Description
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Levonorgestrel.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Levonorgestrel.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Levonorgestrel.
Copanlisib
Major
The metabolism of Copanlisib can be decreased when combined with Levonorgestrel.
Crizotinib
Major
The metabolism of Crizotinib can be decreased when combined with Levonorgestrel.
Liletta Toxicity & Overdose RiskThe lowest toxic dose of levonorgestrel in rats has been found to be greater than 5000mg/kg. Signs of an overdose include nausea and bleeding. If someone has overdosed, they should seek symptom relief and contact a poison control center. Unfortunately, there is no antidote for levonorgestrel overdose.
image of a doctor in a lab doing drug, clinical research

Liletta Novel Uses: Which Conditions Have a Clinical Trial Featuring Liletta?

99 active clinical trials are currently analyzing the potential of Liletta to address Postmenopausal Osteoporosis, Previous Childbearing History, and Endometrial Hyperplasia.
Condition
Clinical Trials
Trial Phases
Hot flashes
18 Actively Recruiting
Phase 1, Phase 4, Not Applicable, Early Phase 1, Phase 2, Phase 3
Endometriosis
30 Actively Recruiting
Early Phase 1, Phase 2, Phase 3, Not Applicable, Phase 4
Has had at least 1 child
0 Actively Recruiting
Menorrhagia
0 Actively Recruiting
Endometrial Hyperplasia
4 Actively Recruiting
Not Applicable, Phase 2, Phase 3
moderate Menopausal Vasomotor Symptoms
0 Actively Recruiting
Menopause
0 Actively Recruiting
Osteoporosis, Postmenopausal
0 Actively Recruiting
Emergency Contraception
1 Actively Recruiting
Phase 4

Liletta Reviews: What are patients saying about Liletta?

5Patient Review
4/15/2022
Liletta for Birth Control
I've been using this for a while now and I really love it. It's gotten to the point where I forget I even have it. Breakthrough spotting has only happened a few times and it hasn't affected my mental health like other hormonal birth controls have. The only downside is that I do get random acne spots more frequently, but that's not too big of a deal.
4.3Patient Review
6/3/2022
Liletta for Birth Control
I got this IUD to help with my heavy flow and for contraception. It does what it's supposed to, but I get nauseous more easily now. To be fair, the minipill gave me the same side effect, so I think that’s just how my body reacts to progestin. Despite the nausea, this IUD doesn’t give me any mood swings, so I can tolerate it.
2.3Patient Review
10/23/2022
Liletta for Birth Control
I've been on this treatment for two years and I'm done with it. Not only have I gained 20 pounds, but I also started experiencing anxiety in the form of intense panic attacks. Now I just feel anxious all the time. Additionally, my acne has gotten worse, my hair has changed, and my hormones are all out of whack.I had Mirena previously and it failed me by getting me pregnant, so I thought I would give something else a shot. But this was a mistake. NuvaRing is next on my list of potential treatments, if not then back to Mirena.
2.3Patient Review
7/1/2022
Liletta for Birth Control
I really dislike Liletta. The insertion was incredibly painful and I bled for a long time afterwards. My period is finally beginning to regulate, but leading up to it I feel crappy. I’ve always gotten headaches, but now my back hurts, I’m nauseous and my poor nipples are tender as hell! Don’t get me started on the BV! AND the strings poke my partner but the doctor claims that’s fine?? 10/10 would not recommend!
2Patient Review
2/19/2022
Liletta for Birth Control
I'm really not a fan of this IUD. I've had it for a month now and have had constant bleeding, headaches, and mood swings the whole time.
View All Reviews
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Patient Q&A Section about liletta

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How is LILETTA different from Mirena?

"Mirena is more effective than Liletta, lasting for up to 5 years instead of 3. Mirena is also able to treat heavy menstrual bleeding, whereas Liletta cannot."

Answered by AI

Can LILETTA cause weight loss?

"Two brands of hormonal IUD, Mirena and Liletta, mention weight gain as a potential side effect. In a clinical study, 5.7% of users said their weight increased while using Liletta."

Answered by AI

What are the side effects of LILETTA IUD?

"Side effects that may occur after placement of the device include pain, bleeding, or dizziness. Cramps, irregular menstrual periods, and vaginal bleeding between periods (spotting) are common, especially during the first few weeks of use. Headache, nausea, breast tenderness, or weight gain may also occur."

Answered by AI

Is LILETTA a good IUD?

"IUDs are becoming more and more popular among American women. Liletta is highly effective and lasts for 3-5 years, making it an excellent option for those considering a long-lasting form of birth control!"

Answered by AI

Clinical Trials for Liletta

Have you considered Liletta clinical trials? We made a collection of clinical trials featuring Liletta, we think they might fit your search criteria.
Have you considered Liletta clinical trials? We made a collection of clinical trials featuring Liletta, we think they might fit your search criteria.
Have you considered Liletta clinical trials? We made a collection of clinical trials featuring Liletta, we think they might fit your search criteria.
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