Endari

Osteoporosis, Anemia, Sickle Cell
Treatment
20 Active Studies for Endari

What is Endari

L-GlutamineThe Generic name of this drug
Treatment SummaryL-glutamine is an amino acid found throughout the body that is involved in many metabolic processes. It helps the body transport nitrogen and can be used as an energy source for cells. In 2017, an oral version of L-glutamine was approved by the FDA to treat sickle cell disease. It is sold under the brand name Endari by Emmaus Medical.
NutreStoreis the brand name
image of different drug pills on a surface
Endari Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
NutreStore
L-Glutamine
2008
2

Effectiveness

How Endari Affects PatientsGlutamine is an amino acid and an important part of protein. It plays an important role in how nitrogen is used by the body. The body converts glutamic acid into glutamine and uses it to make other molecules, such as other amino acids. L-glutamine can help balance the NAD redox potential, which is important for certain body processes.
How Endari works in the bodyL-glutamine helps support the immune system in a number of ways. It helps protect the intestinal tract, and can prevent bacteria from travelling to other parts of the body. In addition, it helps maintain secretory IgA, which stops bacteria from attaching to cells in the body. It is necessary for the production of certain proteins that help fight infection, as well as for the growth and development of white blood cells. L-glutamine can also reduce oxidative damage to red blood cells, which can lead to fewer sickle cell crises and other complications.

When to interrupt dosage

The dosage of Endari depends on the identified illness. The extent of dosage shifts, as per the technique of delivery (e.g. Oral or Capsule) pointed out in the accompanying table.
Condition
Dosage
Administration
Anemia, Sickle Cell
5000.0 mg, , 500.0 mg, 475.0 mg, 750.0 mg
, Powder, for solution, Oral, Powder, for solution - Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral
Osteoporosis
5000.0 mg, , 500.0 mg, 475.0 mg, 750.0 mg
, Powder, for solution, Oral, Powder, for solution - Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral

Warnings

There are 1 known major drug interactions with Endari.
Common Endari Drug Interactions
Drug Name
Risk Level
Description
Lactulose
Moderate
The therapeutic efficacy of Lactulose can be decreased when used in combination with L-Glutamine.
Endari Toxicity & Overdose RiskGenerally, taking up to 21 grams of L-glutamine is safe, but can cause constipation and bloating. In one case, two people with hypomania experienced worsening of their manic symptoms after taking 2 to 4 grams of L-glutamine per day, but the symptoms ceased when they stopped taking the supplement. Common side effects reported in clinical trials of Endari include constipation (21%), nausea (19%), headache (18%), abdominal pain (17%), cough (16%), pain in the limbs (13%), back pain (12%), and chest pain (12%).
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Endari Novel Uses: Which Conditions Have a Clinical Trial Featuring Endari?

45 active studies are investigating the potential of Endari to address Anemia and Sickle Cell Disease.
Condition
Clinical Trials
Trial Phases
Anemia, Sickle Cell
0 Actively Recruiting
Osteoporosis
40 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 4, Phase 3

Endari Reviews: What are patients saying about Endari?

1.7Patient Review
1/31/2019
Endari for Sickle Cell Anemia
I didn't find this to be worth the price tag, and it didn't seem any more effective than if I had just taken a sugar pill.
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Patient Q&A Section about endari

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does Endari do for sickle cell?

"Endari works by increasing the amount of free glutamine in the blood. This can help sickle cells create more antioxidant molecules to neutralize oxidative stress."

Answered by AI

Is Endari FDA approved?

"Endari® is a medication that was approved by the FDA in July 2017 for the treatment of sickle cell disease in adult and pediatric patients five years of age and older. Sales of the medication began in 2018."

Answered by AI

What is Endari used for?

"ENDARI is a medication that is used to help reduce the acute complications that can occur in people with sickle cell disease. It is indicated for use in adults and children who are at least 5 years of age."

Answered by AI

Is Endari better than hydroxyurea?

"Endari reduces the number of pain crises and people who take it also have fewer and shorter hospital stays. The twice-daily powder form may be more challenging than the once-daily hydroxyurea tablets, but it is a non-chemotherapeutic option with minimal side effects."

Answered by AI

Clinical Trials for Endari

Have you considered Endari clinical trials? We made a collection of clinical trials featuring Endari, we think they might fit your search criteria.
Have you considered Endari clinical trials? We made a collection of clinical trials featuring Endari, we think they might fit your search criteria.
Have you considered Endari clinical trials? We made a collection of clinical trials featuring Endari, we think they might fit your search criteria.