Carbidopa

manganese intoxication, carbon monoxide intoxication, Parkinson's Disease + 3 more
Treatment
6 FDA approvals
20 Active Studies for Carbidopa

What is Carbidopa

CarbidopaThe Generic name of this drug
Treatment SummaryA clinical trial is being conducted to test the safety and tolerability of Foscarbidopa, a drug used to treat Parkinson's disease. The trial will involve 24-hour daily exposure to continuous subcutaneous infusion of ABBV-951 in adult participants with Parkinson's disease.
Sinemetis the brand name
image of different drug pills on a surface
Carbidopa Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Sinemet
Carbidopa
1975
299

Approved as Treatment by the FDA

Carbidopa, also called Sinemet, is approved by the FDA for 6 uses which include levodopa-driven nausea and vomiting and Symptomatic Parkinson Disease .
levodopa-driven nausea and vomiting
Symptomatic Parkinson Disease
Used to treat Symptomatic Parkinson Disease in combination with Levodopa
manganese intoxication
Used to treat manganese intoxication in combination with Levodopa
carbon monoxide intoxication
Used to treat carbon monoxide intoxication in combination with Levodopa
Parkinsonism post encephalitic
Used to treat Parkinsonism post encephalitic in combination with Levodopa
Parkinson's Disease
Used to treat Parkinson's Disease (PD) in combination with Levodopa

When to interrupt dosage

The ideal measure of Carbidopa relies upon the diagnosed condition. The dosage fluctuates based on the administration approach featured in the table below.
Condition
Dosage
Administration
carbon monoxide intoxication
10.0 mg, 25.0 mg, , 50.0 mg, 31.25 mg, 37.5 mg, 12.5 mg, 18.75 mg, 23.75 mg, 48.75 mg, 61.25 mg, 36.25 mg, 4.63 mg/mL, 43.75 mg, 5.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Enteral, Gel, Gel - Enteral, Capsule, extended release, Capsule, extended release - Oral, Suspension, Suspension - Enteral
Parkinson's Disease
10.0 mg, 25.0 mg, , 50.0 mg, 31.25 mg, 37.5 mg, 12.5 mg, 18.75 mg, 23.75 mg, 48.75 mg, 61.25 mg, 36.25 mg, 4.63 mg/mL, 43.75 mg, 5.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Enteral, Gel, Gel - Enteral, Capsule, extended release, Capsule, extended release - Oral, Suspension, Suspension - Enteral
Symptomatic Parkinson Disease
10.0 mg, 25.0 mg, , 50.0 mg, 31.25 mg, 37.5 mg, 12.5 mg, 18.75 mg, 23.75 mg, 48.75 mg, 61.25 mg, 36.25 mg, 4.63 mg/mL, 43.75 mg, 5.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Enteral, Gel, Gel - Enteral, Capsule, extended release, Capsule, extended release - Oral, Suspension, Suspension - Enteral
levodopa-driven nausea and vomiting
10.0 mg, 25.0 mg, , 50.0 mg, 31.25 mg, 37.5 mg, 12.5 mg, 18.75 mg, 23.75 mg, 48.75 mg, 61.25 mg, 36.25 mg, 4.63 mg/mL, 43.75 mg, 5.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Enteral, Gel, Gel - Enteral, Capsule, extended release, Capsule, extended release - Oral, Suspension, Suspension - Enteral
Parkinsonism post encephalitic
10.0 mg, 25.0 mg, , 50.0 mg, 31.25 mg, 37.5 mg, 12.5 mg, 18.75 mg, 23.75 mg, 48.75 mg, 61.25 mg, 36.25 mg, 4.63 mg/mL, 43.75 mg, 5.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Enteral, Gel, Gel - Enteral, Capsule, extended release, Capsule, extended release - Oral, Suspension, Suspension - Enteral
manganese intoxication
10.0 mg, 25.0 mg, , 50.0 mg, 31.25 mg, 37.5 mg, 12.5 mg, 18.75 mg, 23.75 mg, 48.75 mg, 61.25 mg, 36.25 mg, 4.63 mg/mL, 43.75 mg, 5.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Enteral, Gel, Gel - Enteral, Capsule, extended release, Capsule, extended release - Oral, Suspension, Suspension - Enteral

Warnings

Carbidopa Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Carbidopa may interact with Pulse Frequency
There are 20 known major drug interactions with Carbidopa.
Common Carbidopa Drug Interactions
Drug Name
Risk Level
Description
Abacavir
Minor
Carbidopa may decrease the excretion rate of Abacavir which could result in a higher serum level.
Acetaminophen
Minor
Carbidopa may decrease the excretion rate of Acetaminophen which could result in a higher serum level.
Aclidinium
Minor
Carbidopa may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Minor
Carbidopa may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Albutrepenonacog alfa
Minor
Carbidopa may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
image of a doctor in a lab doing drug, clinical research

Carbidopa Novel Uses: Which Conditions Have a Clinical Trial Featuring Carbidopa?

No active clinical trials are currently exploring the utilization of Carbidopa for undefined conditions.
Condition
Clinical Trials
Trial Phases
Parkinson's Disease
45 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2, Early Phase 1
carbon monoxide intoxication
0 Actively Recruiting
levodopa-driven nausea and vomiting
0 Actively Recruiting
manganese intoxication
0 Actively Recruiting
Parkinsonism post encephalitic
0 Actively Recruiting
Symptomatic Parkinson Disease
4 Actively Recruiting
Phase 2

Carbidopa Reviews: What are patients saying about Carbidopa?

5Patient Review
7/2/2014
Carbidopa for Parkinson's Disease
Before I was diagnosed, I felt awful-- like I was much older than my 51 years. Shuffling, tremors, loss of balance, incontinence, and constant fatigue were only some of the problems I faced on a daily basis. But after starting this medication regimen, it honestly felt like a miracle. Most of my symptoms have disappeared and while I still get tired easily, it's mostly because now that I feel better overall I push myself to do more.
5Patient Review
4/1/2016
Carbidopa for Extreme Discomfort in Calves when Sitting or Lying Down
This drug is effective in helping me to fall asleep when my legs are hurting from sitting for long periods of time.
5Patient Review
7/2/2014
Carbidopa for Parkinson's Disease
At 51, I felt like an old woman before starting this medication. I had tremors, balance issues, incontinence, and constant pain and fatigue. These meds were a godsend-- they helped me recover most of my quality of life.
5Patient Review
4/1/2016
Carbidopa for Extreme Discomfort in Calves when Sitting or Lying Down
This medication is a godsend. I was dealing with serious pain and discomfort that made it impossible to sleep, but this allowed me to finally get some rest.
5Patient Review
4/1/2016
Carbidopa for Extreme Discomfort in Calves when Sitting or Lying Down
This drug has helped me to manage my chronic pain and get some much needed rest.
5Patient Review
7/2/2014
Carbidopa for Parkinson's Disease
At 51, I felt like I was 90 before treatment. This medication has given me my life back--shuffling, tremors, incontinence, fatigue and chronic pain are almost entirely gone.
4.3Patient Review
1/12/2017
Carbidopa for Extreme Discomfort in Calves when Sitting or Lying Down
I find that I can only take a half-pill at a time, or else I become very dizzy and fall asleep. This medication is meant for restless leg syndrome, but it also provides relief from the pain caused by my bulging discs.
4.3Patient Review
4/8/2014
Carbidopa for Parkinson's Disease
Unfortunately, my husband experiences nausea when taking this medication. However, it does effectively reduce his tremors.
4.3Patient Review
1/12/2017
Carbidopa for Extreme Discomfort in Calves when Sitting or Lying Down
I need to be careful with this medication and only take half a pill at a time, or else I'll get very dizzy and fall asleep. It's effective against restless leg syndrome as well as the pain and discomfort associated with my bulging discs.
4.3Patient Review
4/8/2014
Carbidopa for Parkinson's Disease
My husband gets very nauseous from this medication, but it does help a lot with his tremors.
4.3Patient Review
1/12/2017
Carbidopa for Extreme Discomfort in Calves when Sitting or Lying Down
I find that I can only tolerate a half-pill dosage; any more than that and I become very dizzy and sleepy. This medicine has helped me immensely with my restless leg syndrome, as well as the pain and discomfort from my bulging discs.
4.3Patient Review
4/8/2014
Carbidopa for Parkinson's Disease
My husband gets nauseous from this medication, but it does wonders for his tremors.
4Patient Review
4/7/2016
Carbidopa for Parkinson's Disease
This medication really helps to take the edge off of my symptoms.
4Patient Review
12/20/2017
Carbidopa for Parkinson's Disease
I found that increasing my medication (carbidopa) from 3 times per day to 4 times per day made a big difference.
4Patient Review
4/7/2016
Carbidopa for Parkinson's Disease
This medication does a great job of reducing my symptoms.
4Patient Review
12/20/2017
Carbidopa for Parkinson's Disease
Increasing my medication (carbo) from three times per day to four made a big difference.
4Patient Review
4/7/2016
Carbidopa for Parkinson's Disease
This medication helped to reduce the number and severity of my symptoms.
4Patient Review
12/20/2017
Carbidopa for Parkinson's Disease
I found that increasing my medication from three times a day to four made a significant difference.
3.3Patient Review
3/30/2014
Carbidopa for Parkinson Symptoms
At first, I saw a significant decrease in pain and spasms. However, the effect of the drug has since worn off and I find myself taking more than prescribed. I'm now wondering what the side effects are of taking too much of this medication.
3.3Patient Review
3/30/2014
Carbidopa for Parkinson Symptoms
At first, I saw a considerable decrease in pain and spasms. However, the effect of the drug seems to be wearing off now and I find myself taking more than what was prescribed. I'm wondering what the side effects are of taking too much.
3.3Patient Review
3/30/2014
Carbidopa for Parkinson Symptoms
At first, I saw a significant decrease in pain and spasms. However, the effect of the drug has seemed to wear off and now I find myself taking more than what is prescribed. I am wondering what the side effects are of taking too much of this medication.
2.7Patient Review
12/20/2021
Carbidopa for Parkinson's Disease
I've been on 25/100 three times a day for a month or so now. I'm curious about the relationship to meals. Does it matter if I take the medication before eating? How long before? Or is it better to take the medication after eating, and if so how long after eating?
2.7Patient Review
8/12/2014
Carbidopa for Parkinson's Disease
My husband was just diagnosed with Parkinson's disease. He was diagnosed with MS back in 1988. I'm wondering what kind of treatment is available and how someone can develop both diseases.
2.7Patient Review
12/20/2021
Carbidopa for Parkinson's Disease
I've been on this medication regime for about a month now, and I'm still not sure when the best time to take the pills are. If anyone has any suggestions, that would be great.
2.7Patient Review
8/12/2014
Carbidopa for Parkinson's Disease
My husband was just diagnosed with Parkinson's Disease, and he also has Multiple Sclerosis. We're wondering what kind of treatment options are available to him, and how it's possible to have both diseases.
2.7Patient Review
12/20/2021
Carbidopa for Parkinson's Disease
I've been taking 25/100 three times a day for about a month now. I was wondering if anyone knew the relationship between this medication and meals. Does it matter if I take it before eating? How long before? Or is it better to take it after eating, and if so how long after eating?
2.7Patient Review
8/12/2014
Carbidopa for Parkinson's Disease
My husband has just been diagnosed with Parkinson's Disease, and he also has MS which was diagnosed back in 1988. We're wondering what kind of treatment is available and how someone can end up with both diseases.
2Patient Review
1/3/2022
Carbidopa for Parkinson's Disease
I've been fighting Parkinson's Disease for 15 years and I'm really not seeing any improvement with this treatment. It seems like the same as it was when I first started using it.
2Patient Review
1/3/2022
Carbidopa for Parkinson's Disease
I've been struggling with PD for 15 years and this medication is no better now than it was when I started taking it. It's incredibly frustrating that this is the best that pharmaceutical companies can offer.
2Patient Review
1/3/2022
Carbidopa for Parkinson's Disease
I've been living with PD for 15 years and it really sucks. I've tried this medication before and it's just as bad now as it was then. Is this really the best that pharmaceutical companies can do?
1.3Patient Review
2/22/2020
Carbidopa for Parkinson's Disease
I'm constantly exhausted and shaky. My mobility has decreased to the point where I need a walker, which is frustrating. Additionally, I've lost interest in many activities that I used to enjoy.
1.3Patient Review
2/22/2020
Carbidopa for Parkinson's Disease
I'm always exhausted and shaky. My walking has gotten so bad that I need a walker, and I've lost interest in most things I used to enjoy.
1.3Patient Review
2/22/2020
Carbidopa for Parkinson's Disease
I'm constantly exhausted and often shaky. My mobility has decreased to the point where I need a walker, which is hugely frustrating. Additionally, I've lost interest in many activities that used to bring me joy.
1Patient Review
2/29/2020
Carbidopa for Parkinson Symptoms
This medication caused more problems than it solved. I felt nauseous, dizzy, and couldn't think straight after only a few weeks. Additionally, it gave me wicked eye pain and made it difficult to walk. Going off the medication was just as bad because of all the terrible side effects. There has to be something better out there!
1Patient Review
2/29/2020
Carbidopa for Parkinson Symptoms
This medication had some initial benefits, but soon led to severe nausea, dizziness, and mental confusion. I also experienced tremors that never went away. I had to slowly stop taking the medication because of all the bad side effects. There has to be something better out there than this wicked medication!
1Patient Review
2/29/2020
Carbidopa for Parkinson Symptoms
Though it seemed to help at first, about two weeks in I started experiencing a range of negative side effects, like nausea and dizziness. My tremors never went away. I had to slowly go off the medication because of all the bad side effects. There has to be something better out there than this wicked medication!
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about carbidopa

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the drug carbidopa used for?

"Carbidopa and levodopa combination is used to treat Parkinson's disease, a disorder of the central nervous system."

Answered by AI

What does carbidopa do for Parkinson's?

"Israel said researchers have found that levodopa, the most common treatment for [Parkinson's disease](https://www.withpower.com/clinical-trials/parkinson's-disease), may cause the very same symptoms it is meant to relieve.

According to Israel, researchers have found that levodopa, the most common treatment for Parkinson's disease, may cause the very same symptoms it is meant to relieve."

Answered by AI

What are the long term side effects of carbidopa levodopa?

"Sinemet is the most effective medicine, but it is associated with high risks of long-term side effects. Levodopa is less effective but causes fewer side effects."

Answered by AI

When should I take carbidopa?

"This medication is to be taken by mouth, with or without food, as directed by a doctor. It should be taken 4 to 8 hours apart, while awake. The doses should not be crushed or chewed, as this could release all of the drug at once and increase the risk of experiencing side effects."

Answered by AI

Clinical Trials for Carbidopa

Have you considered Carbidopa clinical trials? We made a collection of clinical trials featuring Carbidopa, we think they might fit your search criteria.
Have you considered Carbidopa clinical trials? We made a collection of clinical trials featuring Carbidopa, we think they might fit your search criteria.
Have you considered Carbidopa clinical trials? We made a collection of clinical trials featuring Carbidopa, we think they might fit your search criteria.