← Back to Search

Other

Gly-low Cocktail for Obesity

Phase 1 & 2
Waitlist Available
Led By Marshall Stoller, MD
Research Sponsored by University of California, San Francisco
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Obese individuals with BMI >27
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline to 1 year
Awards & highlights

Study Summary

This trial is testing whether a methylglyoxal-lowering cocktail can help people with obesity by reducing their food intake and weight.

Who is the study for?
This trial is for adults under 50 years old with obesity, defined as having a body mass index (BMI) over 27. It aims to test if a special cocktail of compounds can help reduce their appetite and lower markers related to insulin resistance.Check my eligibility
What is being tested?
The study is testing 'Gly-low', a mix including alpha-lipoic acid, nicotinamide, thiamine, pyridoxamine, and piperine against a placebo. Gly-low has shown promise in reducing food intake and weight in animal studies and may influence aging pathways.See study design
What are the potential side effects?
Potential side effects are not detailed but could include reactions to the ingredients like stomach upset or allergic responses. Since it affects metabolic pathways, there might be changes in energy levels or other metabolic disturbances.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am obese with a BMI over 27.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline and one year
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and one year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in body mass index (BMI) from baseline to 1 year
Change in frailty from baseline to 1 year
Cognition
Secondary outcome measures
Blood Marker Glucose for Aging and Insulin Resistance
Other outcome measures
Elder Abuse

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: InterventionExperimental Treatment1 Intervention
MGO cocktail containing a combination of alpha-lipoic acid, nicotinamide, thiamine, pyridoxamine, and piperine
Group II: ControlPlacebo Group1 Intervention
sugar pill

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

University of California, San FranciscoLead Sponsor
2,503 Previous Clinical Trials
15,236,555 Total Patients Enrolled
33 Trials studying Obesity
10,901 Patients Enrolled for Obesity
Marshall Stoller, MDPrincipal InvestigatorUniversity of California, San Francisco
1 Previous Clinical Trials
10 Total Patients Enrolled

Media Library

Gly-low (Other) Clinical Trial Eligibility Overview. Trial Name: NCT05083546 — Phase 1 & 2
Obesity Research Study Groups: Control, Intervention
Obesity Clinical Trial 2023: Gly-low Highlights & Side Effects. Trial Name: NCT05083546 — Phase 1 & 2
Gly-low (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05083546 — Phase 1 & 2
Obesity Patient Testimony for trial: Trial Name: NCT05083546 — Phase 1 & 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any open enrollment opportunities for this trial?

"The trial details listed on clinicaltrials.gov confirm that this study is not actively recruiting participants at the present moment, as it was first posted December 1st 2023 and last updated September 13th 2022. Despite this, there are currently 1193 other medical trials looking for enrolment right now."

Answered by AI

Who else is applying?

What state do they live in?
Utah
California
How old are they?
65+
18 - 65
What site did they apply to?
University of California, San Francisco
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
2
0

Why did patients apply to this trial?

Weight gain has caused other medical problems.
PatientReceived 2+ prior treatments

How responsive is this trial?

Typically responds via
Email
Average response time
  • < 2 Days
Most responsive sites:
  1. University of California, San Francisco: < 48 hours
Recent research and studies
clinicaltrials.govStudy
Methylglyoxal (MGO) Lowering Cocktail to Reduce Appetite in Obese Individuals
2024. "Methylglyoxal (MGO) Lowering Cocktail to Reduce Appetite in Obese Individuals". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05083546.
~67 spots leftby Dec 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top