Diet Modification for Obesity
(WYE Trial)
Trial Summary
Do I have to stop taking my current medications?
The trial requires you to stop taking weight-loss medications or medications that alter appetite, like atypical anti-psychotics. Other medications are not specified, so check with the trial coordinators.
Will I have to stop taking my current medications?
The trial requires that you stop taking weight-loss medications or any medications known to alter appetite, like certain anti-psychotics. If you're on these medications, you would need to stop them to participate.
What data supports the idea that Diet Modification for Obesity is an effective treatment?
The available research shows that diet modification is a central part of treating obesity. Lower-calorie diets consistently lead to more weight loss in the short term compared to higher-calorie diets. While different diets may have short-term benefits, like low-carb diets being more effective than low-fat ones, the key to success is sticking to the diet. Dietitians play a crucial role by providing personalized advice, which helps people make lasting changes to their eating habits. This approach, combined with exercise and behavior changes, can lead to effective and sustainable weight loss.12345
What data supports the effectiveness of the treatment for obesity?
Research shows that dietary modifications, such as reducing calorie intake and adjusting macronutrient composition, can lead to short-term weight loss. Long-term success often depends on improving adherence to these dietary changes, and personalized nutritional therapy led by dietitians can help make these changes sustainable.12345
What safety data exists for diet modification treatments for obesity?
The research indicates that dietary modification is a central component of obesity treatment, often involving caloric restriction and changes in macronutrient composition. While short-term weight loss is commonly achieved, long-term effects vary. Safety data specifically related to nutrient intake shows that some nutrients may fall below recommended levels during dietary interventions, such as iron, thiamin, and calcium. However, nutrient density for other nutrients like protein, fiber, and vitamins may increase. Overall, dietary modification is considered a primary treatment for obesity, but specific safety data on long-term nutrient adequacy and potential deficiencies should be considered.12678
Is diet modification generally safe for humans?
Is Diet modification a promising treatment for obesity?
Yes, diet modification is a promising treatment for obesity. It is a key part of obesity treatment and can lead to weight loss by reducing calorie intake. Different diets can help people lose weight in the short term, and improving how well people stick to their diets can help with long-term weight loss.12679
How is the treatment 'Diet Modification for Obesity' different from other treatments for obesity?
Diet Modification for Obesity is unique because it focuses on changing dietary patterns and energy intake, which can lead to weight loss through various mechanisms beyond just calorie restriction, such as improving dietary adherence. Unlike some treatments that rely on medication, this approach emphasizes personalized dietary changes and behavioral adjustments to achieve weight loss.12679
What is the purpose of this trial?
The purpose of this study is to use magnetic resonance imaging (MRI) to evaluate the human hypothalamus for signs of inflammation in response to specific diets. This research may lead to a better understanding of how poor nutritional quality may lead to obesity through effects on regions of the brain known to regulate body weight.
Research Team
Ellen A Schur, MD, MS
Principal Investigator
University of Washington
Eligibility Criteria
This trial is for overweight individuals aged 20-40 with a BMI of 25-29.9, willing to try a new diet for two weeks and undergo MRI scans. It's not suitable for those with major health issues, metal implants, extreme diets like veganism, or who are pregnant.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Diet Intervention
Participants follow a specific diet for the study
Follow-up
Participants are monitored for safety and effectiveness after diet intervention
Treatment Details
Interventions
- Diet modification #1
- Diet modification #2
- Diet modification #3
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Washington
Lead Sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator