42 Participants Needed

Diet Modification for Obesity

(WYE Trial)

MW
WS
Overseen ByWYE Study
Age: 18 - 65
Sex: Any
Trial Phase: Academic
Sponsor: University of Washington
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

Do I have to stop taking my current medications?

The trial requires you to stop taking weight-loss medications or medications that alter appetite, like atypical anti-psychotics. Other medications are not specified, so check with the trial coordinators.

Will I have to stop taking my current medications?

The trial requires that you stop taking weight-loss medications or any medications known to alter appetite, like certain anti-psychotics. If you're on these medications, you would need to stop them to participate.

What data supports the idea that Diet Modification for Obesity is an effective treatment?

The available research shows that diet modification is a central part of treating obesity. Lower-calorie diets consistently lead to more weight loss in the short term compared to higher-calorie diets. While different diets may have short-term benefits, like low-carb diets being more effective than low-fat ones, the key to success is sticking to the diet. Dietitians play a crucial role by providing personalized advice, which helps people make lasting changes to their eating habits. This approach, combined with exercise and behavior changes, can lead to effective and sustainable weight loss.12345

What data supports the effectiveness of the treatment for obesity?

Research shows that dietary modifications, such as reducing calorie intake and adjusting macronutrient composition, can lead to short-term weight loss. Long-term success often depends on improving adherence to these dietary changes, and personalized nutritional therapy led by dietitians can help make these changes sustainable.12345

What safety data exists for diet modification treatments for obesity?

The research indicates that dietary modification is a central component of obesity treatment, often involving caloric restriction and changes in macronutrient composition. While short-term weight loss is commonly achieved, long-term effects vary. Safety data specifically related to nutrient intake shows that some nutrients may fall below recommended levels during dietary interventions, such as iron, thiamin, and calcium. However, nutrient density for other nutrients like protein, fiber, and vitamins may increase. Overall, dietary modification is considered a primary treatment for obesity, but specific safety data on long-term nutrient adequacy and potential deficiencies should be considered.12678

Is diet modification generally safe for humans?

Diet modification, including changes in nutrient intake and dietary patterns, is generally considered safe for humans. Studies have shown that it can lead to improved nutrient intake and is a key part of managing conditions like obesity and diabetes.12678

Is Diet modification a promising treatment for obesity?

Yes, diet modification is a promising treatment for obesity. It is a key part of obesity treatment and can lead to weight loss by reducing calorie intake. Different diets can help people lose weight in the short term, and improving how well people stick to their diets can help with long-term weight loss.12679

How is the treatment 'Diet Modification for Obesity' different from other treatments for obesity?

Diet Modification for Obesity is unique because it focuses on changing dietary patterns and energy intake, which can lead to weight loss through various mechanisms beyond just calorie restriction, such as improving dietary adherence. Unlike some treatments that rely on medication, this approach emphasizes personalized dietary changes and behavioral adjustments to achieve weight loss.12679

What is the purpose of this trial?

The purpose of this study is to use magnetic resonance imaging (MRI) to evaluate the human hypothalamus for signs of inflammation in response to specific diets. This research may lead to a better understanding of how poor nutritional quality may lead to obesity through effects on regions of the brain known to regulate body weight.

Research Team

EA

Ellen A Schur, MD, MS

Principal Investigator

University of Washington

Eligibility Criteria

This trial is for overweight individuals aged 20-40 with a BMI of 25-29.9, willing to try a new diet for two weeks and undergo MRI scans. It's not suitable for those with major health issues, metal implants, extreme diets like veganism, or who are pregnant.

Inclusion Criteria

Overweight: BMI 25-29.9 kg/m2
Willing to undergo randomly assigned 14-day diet modification
I am between 20 and 40 years old.

Exclusion Criteria

I have anemia or problems with my kidney or liver.
Lifetime eating disorder
Weight > 350 pounds (MRI limit)
See 10 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Diet Intervention

Participants follow a specific diet for the study

1 week
1 visit (in-person) for MRI

Follow-up

Participants are monitored for safety and effectiveness after diet intervention

2 weeks

Treatment Details

Interventions

  • Diet modification #1
  • Diet modification #2
  • Diet modification #3
Trial Overview The study tests how three different diet modifications affect brain inflammation related to obesity by using MRI scans of the hypothalamus over a period of 14 days.
Participant Groups
3Treatment groups
Experimental Treatment
Group I: Assigned Diet #3Experimental Treatment1 Intervention
Group II: Assigned Diet #2Experimental Treatment1 Intervention
Group III: Assigned Diet #1Experimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Washington

Lead Sponsor

Trials
1,858
Recruited
2,023,000+

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Collaborator

Trials
2,513
Recruited
4,366,000+

Findings from Research

Lower-calorie diets consistently lead to greater short-term weight loss (less than 6 months) compared to higher-calorie diets, but this advantage tends to diminish over the long term (beyond 12 months).
While different macronutrient compositions (like low-carb vs. low-fat) may show short-term benefits, there are few significant long-term differences in weight loss, highlighting the importance of dietary adherence for sustained results.
Dietary interventions for obesity: clinical and mechanistic findings.Chao, AM., Quigley, KM., Wadden, TA.[2022]
Dietary counseling can lead to modest weight loss in overweight adults, with a maximum reduction of about 1.9 BMI units (approximately 6%) observed at 12 months compared to usual care.
However, the effectiveness of dietary counseling diminishes over time, with participants regaining weight at a rate of about 0.02 to 0.03 BMI units per month during maintenance phases, highlighting the need for ongoing support and effective strategies to sustain weight loss.
Meta-analysis: the effect of dietary counseling for weight loss.Dansinger, ML., Tatsioni, A., Wong, JB., et al.[2022]
A combination of dietary measures, including fat-reduced and carbohydrate-enhanced diets, can lead to significant weight loss in many obese patients, especially when paired with exercise and behavior modification.
If conservative methods fail after several years, adjunctive drug treatments or surgical options may be necessary for effective long-term weight management.
[Long-term weight reduction. Current therapy approaches in obesity].Lichtenstein, S., Schulz, B., Hamann, A.[2015]

References

Dietary interventions for obesity: clinical and mechanistic findings. [2022]
Meta-analysis: the effect of dietary counseling for weight loss. [2022]
[Long-term weight reduction. Current therapy approaches in obesity]. [2015]
4.Czech Republicpubmed.ncbi.nlm.nih.gov
Role of dietitian in obese patients care. [2020]
The Effectiveness of Nutritional Strategies in the Treatment and Management of Obesity: A Systematic Review. [2023]
[Changes in vitamins intake in overweight and obese adults after low-energy diets]. [2014]
Changes in nutrient intake during a behavioral weight control program. [2008]
Advances in diabetes for the millennium: nutritional therapy of type 2 diabetes. [2018]
Dietary quality differences between women with and without weight loss in nutritional treatment. [2020]
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