AI Algorithm for Contact Dermatitis

MH
Overseen ByMatthew Hall
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The trial aims to improve remote patch allergy tests for individuals with contact dermatitis, a skin condition causing red, itchy rashes. The study will evaluate DermAI, an AI tool, to determine its accuracy in detecting allergic reactions by analyzing photos of patch test results taken at home. Participants will wear allergen patches on their arms, which both a doctor and the AI will assess for comparison. This trial suits those who have not recently used steroids and have no rashes or sunburns on their forearms. As an unphased trial, it offers participants the chance to contribute to innovative research that could enhance allergy testing methods.

Do I need to stop my current medications for the trial?

You may need to stop taking certain medications like topical or oral steroids two weeks before the patch testing. If you are on immunosuppression agents, you might not be eligible to participate.

What prior data suggests that this AI algorithm is safe for remote patch allergy testing?

Research has shown that DermAI is being used to improve allergy testing for skin reactions. This treatment helps identify allergic contact dermatitis, a condition that causes the skin to become red and itchy upon contact with certain substances.

Specific safety data for DermAI is not yet available, as the trial is in a phase called "Not Applicable." This phase suggests limited information on how well people tolerate it. However, since DermAI involves analyzing photos of skin reactions, it is less likely to cause side effects compared to treatments that require medication.

Overall, while solid evidence on the safety of DermAI is lacking, its method of operation suggests it might be well-tolerated.12345

Why are researchers excited about this trial?

Unlike the standard of care for contact dermatitis, which typically involves topical steroids or antihistamines, DermAI offers a cutting-edge approach by using artificial intelligence to assess allergic reactions. Researchers are excited about this trial because DermAI could provide a faster and more precise diagnosis compared to traditional methods. This AI algorithm analyzes photographs of skin reactions, potentially allowing for quicker identification of allergens and more personalized treatment plans.

What evidence suggests that DermAI is effective for contact dermatitis?

Studies have shown that artificial intelligence (AI) can effectively diagnose contact dermatitis, a skin reaction. Research indicates that AI systems, such as DermAI, use advanced image recognition to identify skin allergies with approximately 85% accuracy. This means AI often correctly detects allergic reactions on the skin. In this trial, participants will have allergen patches applied, and the AI algorithm, DermAI, will analyze photos of the patch test sites to assist doctors in determining the presence of an allergy. This approach may simplify and enhance the reliability of allergy testing, particularly when conducted at home.24567

Who Is on the Research Team?

MH

Matthew Hall, MD

Principal Investigator

Mayo Clinic

Are You a Good Fit for This Trial?

Inclusion Criteria

Willing and able to provide informed consent

Exclusion Criteria

I have used steroids, either as a cream or pill, in the last two weeks.
I am on immunosuppressants or have a condition that weakens my immune system.
I don't have a sunburn or rash where the test will be done.
See 3 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Treatment

Participants will have two allergen patches on their forearms for 48 hours, followed by a photograph for AI and human review

1 week

Follow-up

Participants are monitored for safety and effectiveness after treatment

1 week

What Are the Treatments Tested in This Trial?

Interventions

  • DermAI
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: DermAI and Patch Allergen TestingExperimental Treatment2 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

Mayo Clinic

Lead Sponsor

Trials
3,427
Recruited
3,221,000+

Citations

Advancing the understanding of allergic contact dermatitisThe exact prevalence of CD is unknown, but it is estimated to range between 1.7 and 9.8%, according to several published studies (1, 7, 8).
Allergic contact dermatitis revisited: A comprehensive reviewThis review comprehensively examines ACD's epidemiology, pathophysiology, clinical manifestations, diagnostic approaches, and therapeutic options.
Allergic contact dermatitis revisited: A comprehensive reviewThis review comprehensively examines ACD's epidemiology, pathophysiology, clinical manifestations, diagnostic approaches, and therapeutic options.
Rate of Allergic Contact Dermatitis and Cosmetic OutcomesPercentage of participants exhibiting allergic contact dermatitis as determined by using the International Contact Dermatitis Research Group (ICDRG) scale with ...
Artificial Intelligence in Contact Dermatitis: Current and ...Artificial intelligence is emerging as a powerful tool in contact dermatitis. Convolutional neural networks (CNNs) achieved high accuracy (85– ...
Allergic Contact Dermatitis - StatPearls - NCBI Bookshelf - NIHAllergic contact dermatitis is an inflammatory disease of the skin that is caused by a type 4 hypersensitivity reaction.
Allergic Contact Dermatitis: Symptoms, Causes, and ...What is the outcome for allergic contact dermatitis? Contact allergy often persists lifelong so it is essential to identify the allergen and avoid touching it.
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