Islet Transplantation for Type 1 Diabetes
What You Need to Know Before You Apply
What is the purpose of this trial?
This study is evaluating whether islet transplantation is safe and effective for people with type 1 diabetes.
Will I have to stop taking my current medications?
The trial requires that participants stop taking any antidiabetic medication other than insulin at least 4 weeks before enrolling. If you are on other medications, it's best to discuss with the trial team to see if they are allowed.
Is islet transplantation for type 1 diabetes safe for humans?
Islet transplantation has been studied for safety, with some adverse events reported, such as elevated liver enzymes, infections, and bleeding, mostly related to the transplant procedure and the drugs used to prevent rejection. These events were generally resolved without long-term effects, but the procedure still requires careful monitoring and improvements in safety protocols.12345
How is the islet transplantation treatment different from other treatments for type 1 diabetes?
Islet transplantation involves implanting insulin-producing cells from a donor into a person with type 1 diabetes, offering a more natural way to regulate blood sugar compared to regular insulin injections. Unlike whole pancreas transplants, it is a simpler and safer procedure, though it still requires immunosuppressive drugs to prevent rejection.678910
What data supports the effectiveness of the treatment Islets of Langerhans for Type 1 Diabetes?
Islet transplantation, which involves replacing insulin-producing cells, has shown promise in controlling blood sugar levels in people with Type 1 diabetes. Recent studies highlight improvements in insulin independence and better control of blood sugar, reducing severe low blood sugar episodes and improving quality of life.611121314
Who Is on the Research Team?
Jose Oberholzer, MD
Principal Investigator
University of Illinois at Chicago
Are You a Good Fit for This Trial?
This trial is for Type 1 diabetes patients who've had the disease for over 5 years and experienced severe hypoglycemia or have reduced hypoglycemia awareness. Exclusions include those with pancreatitis, kidney issues, substance abuse, certain infections like hepatitis or HIV, pregnancy/breastfeeding without contraception use, some heart conditions, and other specific health concerns.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Islet Transplantation
Participants receive up to 3 allogeneic pancreatic islet transplants
Follow-up
Participants are monitored for safety and effectiveness after each transplant
Long-term Follow-up
Participants may enroll for additional follow-up to evaluate islet function and manage immunosuppressive drug levels
What Are the Treatments Tested in This Trial?
Interventions
- Islets of Langerhans
Find a Clinic Near You
Who Is Running the Clinical Trial?
CellTrans Inc.
Lead Sponsor