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Modafinil for Attention Deficits (LC Trial)

Phase 4

Recruiting

Research Sponsored by University of California, Davis

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Between the ages of 18 - 60 years of age

Typically developing, healthy adult

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1 hour

Awards & highlights

LC Trial Summary

This trial proposes to measure and understand activity of the brain's locus coeruleus, a small area in the pons involved in attention, goal pursuit, ADHD and schizophrenia.

Who is the study for?

This trial is for healthy adults aged 18-60 who can undergo MRI scans. It's not suitable for those with metal implants, pacemakers, or claustrophobia. Pregnant or nursing individuals, people on psychotropic meds within the last week, and those with a history of severe mental health issues or substance abuse are excluded.Check my eligibility

What is being tested?

The study tests Modafinil's effect on attention by using advanced brain imaging to observe activity in the locus coeruleus (LC), which is involved in cognitive functions and may be linked to disorders like ADHD and schizophrenia.See study design

What are the potential side effects?

Modafinil can cause headaches, nausea, nervousness, dizziness, difficulty sleeping. People with known hypersensitivity to Modafinil might experience allergic reactions.

LC Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am between 18 and 60 years old.

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I am a healthy adult without any developmental delays.

LC Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1 hour

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1 hour

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 hour for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Brain activity - BOLD response

Secondary outcome measures

Attention on Oddball and POP task

LC Trial Design

2Treatment groups

Active Control

Placebo Group

Group I: ModafinilActive Control1 Intervention

Single oral dose (200 mg) of medication versus placebo given to healthy control subjects

Group II: PlaceboPlacebo Group1 Intervention

Oral placebo

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of California, DavisLead Sponsor

911 Previous Clinical Trials

4,709,479 Total Patients Enrolled

1 Trials studying Attention

26 Patients Enrolled for Attention

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

For whom is the eligibility criteria for this research project suited?

"In order to be accepted into this clinical study, potential participants must have a diagnosis of attention disorder and meet the age criteria (18-60). A maximum of 40 patients will be enrolled."

Answered by AI

Is enrollment open to individuals aged 20 and above in this trial?

"To participate in this study, individuals must be aged between 18 and 60 years old."

Answered by AI

Has Modafinil earned the Federal Drug Administration's stamp of approval?

"As Modafinil is currently in a Phase 4 trial, it has been given the highest safety score of 3 due to its pre-existing approval status."

Answered by AI

What is the scope of participation in this experiment?

"Affirmative. According to clinicaltrials.gov, this trial is presently recruiting participants and was initially posted on October 1st 2023 with a recent update on September 10th 2023. 40 individuals need to be enrolled from one medical centre in order for the study to proceed."

Answered by AI

Are there any opportunities to participate in this scientific experiment presently available?

"Affirmative. Per the information on clinicaltrials.gov, this trial is actively searching for volunteers to take part in their research. The study was first published on October 1st 2023 and has been updated as recent as September 10th 2023. A total of 40 participants are required at one location."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Investigation of Locus Coeruleus Function in Sustained Attention

Julie Schweitzer, PhD 2023. "Investigation of Locus Coeruleus Function in Sustained Attention". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06041048.