Treatment for Bone Resorption

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora, CO
Bone Resorption+2 More
Eligibility
18+
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether exercise and calcium supplements can help prevent bone loss during exercise.

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Eligible Conditions

  • Bone Resorption
  • Exercise
  • Bone Formation

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether Treatment will improve 2 primary outcomes, 9 secondary outcomes, and 5 other outcomes in patients with Bone Resorption. Measurement will happen over the course of Urinary Ca excretion is measured over the 4 hours of recovery after the 1st, 8th, and 16th exercise sessions.

BMD of the lumbar spine and proximal femur is measured at baseline
Bone mineral density (BMD)
FFM is measured at baseline
Fat-free mass (FFM)
FM is measured at baseline
Fat mass (FM)
HRmax is measured at baseline during a maximal treadmill test
Maximal heart rate (HRmax)
Hour 24
Hematocrit (Hct)
Hour 24
Hemoglobin (Hgb)
Hour 24
P1NP
Hour 24
Serum phosphorus (PO4)
Hour 24
Serum parathyroid hormone (PTH)
Hour 24
Serum ionized Ca (iCa)
Hour 24
Serum total Ca (tCa)
Hour 4
C-terminal peptide of type 1 collagen (CTX)
The primary outcome for Aim 2 is the change in the pre-exercise P1NP (15 minutes before the start of exercise) from the 1st to the 16th exercise session.
Procollagen 1 intact N-terminal propeptide (P1NP)
Hour 4
Urinary calcium excretion (uCa)
Urinary total calcium (tCa)
VO2peak is measured at baseline during a maximal treadmill test
Peak aerobic power (VO2peak)

Trial Safety

Safety Estimate

1 of 3

Trial Design

0 Treatment Group

This trial requires 30 total participants across 0 different treatment group

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: bmd of the lumbar spine and proximal femur is measured at baseline
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly bmd of the lumbar spine and proximal femur is measured at baseline for reporting.

Closest Location

Rocky Mountain Regional VA Medical Center, Aurora, CO - Aurora, CO

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There is one eligibility criterion to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Female and male Veterans aged 25 to 45 y and 55 to 75 y will be enrolled. Eligible volunteers will be normally active (e.g., recreational cycling or walking) but will not participate in regular moderate-to-vigorous exercise. Women will be premenopausal with regular menstrual cycles or postmenopausal, defined as absence of menses for at least 12 mo or, in those who underwent a hysterectomy, a serum follicle stimulating hormone (FSH) >30 mIU/mL.

Patient Q&A Section

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Other questions from users

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any geographic restrictions to consider when applying for this trial?

Patients from any state can participate in this trial, so long as they are able to attend all treatment sessions.

Will my insurance cover participating in this trial?

In order to understand how insurance coverage works for this trial, you will need to contact the study coordinator.

See if you qualify for this trial
Get access to this novel treatment for Bone Resorption by sharing your contact details with the study coordinator.