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Exercise Training for Parkinson's Disease

Q: Are there any current opportunities for individuals to partake of this research study?

According to clinicaltrials.gov, this medical trial commenced on July 8th 2021 and has since been updated as recently as February 7th 2022; presently it is actively searching for enrollees.

Q: Who is eligible to be part of this research project?

This research project, which has an anticipated enrollment of 120 participants, is searching for people with <a href="https://www.withpower.com/clinical-trials/parkinson&#x27;s-disease">Parkinson's disease</a> aged between 45 and 100 years old.

Q: Does this research encompass participants above the age of 35?

This medical research is seeking participants aged 45 and over but not exceeding 100 years old.

Q: How many participants have signed up for this clinical experiment?

Affirmative. As per clinicaltrials.gov, this medical trial is actively searching for participants and was first published on July 8th 2021. The most recent update occurred on February 7th 2022 and currently 1 site is enrolling 120 patients in the study.

N/A

Recruiting

Led By Amy Amara, MD, PhD

Research Sponsored by University of Alabama at Birmingham

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Montreal Cognitive Assessment (MoCA) score ≥ 18 and <26 (performed at screening visit)

On stable medications for at least 4 weeks prior to study entry without expecting to change medications for the duration of the study

Timeline

Screening 3 weeks

Treatment Varies

Follow Up change from baseline to twelve week and change from twelve weeks to 24 weeks.

Awards & highlights

Study Summary

This trial looks at whether exercise can help improve cognition in people with Parkinson's, and whether slow wave sleep is a marker of how well someone will respond to exercise rehabilitation.

Who is the study for?

This trial is for people aged 45 or older with Parkinson's Disease (PD) who can walk without help and have mild to moderate symptoms. They should be on stable PD meds, not expecting changes during the study, and score between 18-26 on a cognitive test. Those with serious heart conditions, other types of Parkinsonism, deep brain stimulation implants, untreated sleep disorders or those already doing regular exercise cannot join.Check my eligibility

What is being tested?

The study tests how different exercise programs—Endurance Training (ET), Delayed Exercise Training (DE), Progressive Resistance Training (PRT)—affect thinking skills in PD patients and if Slow Wave Sleep can indicate improvement from these exercises.See study design

What are the potential side effects?

While specific side effects are not listed for this type of physical activity intervention, general risks may include muscle soreness, fatigue, joint pain or injury. The safety will be monitored closely given the participants' condition.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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My cognitive test score is between 18 and 25.

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My medications have been the same for the last 4 weeks and won't change during the study.

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My Parkinson's disease is at a moderate stage.

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I have Parkinson's disease diagnosed with slow movements and possibly tremor, stiffness, or balance issues.

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I am 45 years old or older.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline to twelve weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline to twelve weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to twelve weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in Cognition in Stroop inhibition

Secondary outcome measures

Change in slow wave sleep (SWS)

Trial Design

2Treatment groups

Active Control

Placebo Group

Group I: Exercise GroupActive Control2 Interventions

PD participants randomized to progressive resistance training PRT) will have 12 weeks of supervised PRT 3 times per week. After the 1st 12 weeks, responders to PRT (increase in slow wave sleep) will continue PRT for an additional 12 weeks, non-responders to PRT will transition to endurance training (ET).

Group II: Delayed Exercise GroupPlacebo Group2 Interventions

PD participants randomized to the delayed exercise control group will not exercise for the 1st 12 weeks of the study. After the 1st 12 weeks, participants in the delayed exercise group will transition to PRT for the 2nd 12 weeks.

0 / 5Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of Alabama at BirminghamLead Sponsor

1,590 Previous Clinical Trials

2,281,234 Total Patients Enrolled

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)NIH

1,964 Previous Clinical Trials

2,674,610 Total Patients Enrolled

University of Colorado, DenverLead Sponsor

1,736 Previous Clinical Trials

2,149,075 Total Patients Enrolled

Media Library

Delayed Exercise Training (DE) Clinical Trial Eligibility Overview. Trial Name: NCT04796506 — N/A

Parkinson's Disease Research Study Groups: Exercise Group, Delayed Exercise Group

Parkinson's Disease Clinical Trial 2023: Delayed Exercise Training (DE) Highlights & Side Effects. Trial Name: NCT04796506 — N/A

Delayed Exercise Training (DE) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04796506 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any current opportunities for individuals to partake of this research study?

"According to clinicaltrials.gov, this medical trial commenced on July 8th 2021 and has since been updated as recently as February 7th 2022; presently it is actively searching for enrollees."

Answered by AI

Who is eligible to be part of this research project?

"This research project, which has an anticipated enrollment of 120 participants, is searching for people with Parkinson's disease aged between 45 and 100 years old."

Answered by AI

Does this research encompass participants above the age of 35?

"This medical research is seeking participants aged 45 and over but not exceeding 100 years old."

Answered by AI

How many participants have signed up for this clinical experiment?

"Affirmative. As per clinicaltrials.gov, this medical trial is actively searching for participants and was first published on July 8th 2021. The most recent update occurred on February 7th 2022 and currently 1 site is enrolling 120 patients in the study."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Slow Wave Sleep as a Biomarker of Rehabilitation-induced Cognitive Improvement in PD

Amy Amara 2021. "Slow Wave Sleep as a Biomarker of Rehabilitation-induced Cognitive Improvement in PD". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04796506.

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