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Diagnostic Test

Advanced Imaging-Guided CRT for Heart Failure

N/A
Recruiting
Led By Kenneth C Bilchick, MD
Research Sponsored by University of Virginia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Chronic systolic HF
Guideline-based class I or II indication for CRT
Timeline
Screening 3 weeks
Treatment Varies
Follow Up one year
Awards & highlights

Study Summary

This trial is testing a new way to do a heart procedure, using MRI and CT scans to guide it, versus the standard way.

Who is the study for?
This trial is for individuals with chronic systolic heart failure, having a left ventricular ejection fraction (LVEF) of 35% or less, and who meet the criteria for Cardiac Resynchronization Therapy (CRT). Participants must be able to consent. Those with metal in their body, severe claustrophobia, kidney issues, liver transplant, gadolinium allergy or significant irregular heartbeat are excluded.Check my eligibility
What is being tested?
The study compares CRT guidance using advanced imaging techniques like cardiac magnetic resonance (CMR) and computed tomography angiography (CTA), against standard CRT procedures. Patients will be randomly assigned to either the CMR/CTA-guided group or the standard procedure group.See study design
What are the potential side effects?
Potential side effects may include discomfort from lying still during imaging tests, reactions to contrast agents used in scans such as allergic reactions or kidney function impairment. The risk of radiation exposure from CTA is also present.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have chronic heart failure with reduced ejection fraction.
Select...
My condition is recommended for cardiac resynchronization therapy.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~one year
This trial's timeline: 3 weeks for screening, Varies for treatment, and one year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Left ventricular end-systolic volume (LVESV) improvement

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: InterventionExperimental Treatment1 Intervention
CMR-Guided CRT
Group II: ControlActive Control1 Intervention
Standard CRT

Find a Location

Who is running the clinical trial?

University of VirginiaLead Sponsor
753 Previous Clinical Trials
1,244,860 Total Patients Enrolled
12 Trials studying Heart Failure
1,552 Patients Enrolled for Heart Failure
Kenneth C Bilchick, MDPrincipal InvestigatorUniversity of Virginia Health System
2 Previous Clinical Trials
90 Total Patients Enrolled
2 Trials studying Heart Failure
90 Patients Enrolled for Heart Failure

Media Library

CMR/CTA Guidance for CRT (Diagnostic Test) Clinical Trial Eligibility Overview. Trial Name: NCT03398369 — N/A
CMR/CTA Guidance for CRT (Diagnostic Test) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03398369 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there still openings in this experiment for volunteers?

"Affirmative, the details on clinicaltrials.gov demonstrate that this medical experiment is currently recruiting patients. The trial was initially advertised on May 1st 2018 and was last modified February 4th 2020. Researchers are aiming to enlist 180 participants from a single research facility."

Answered by AI

Does this investigation welcome elderly individuals as participants?

"According to the listed prerequisites, individuals aged 20-90 may be considered for enrollment in this trial."

Answered by AI

How many subjects are being observed in this medical research?

"Yes, the clinical trial is actively seeking participants according to information hosted on clinicaltrials.gov. The study was initially posted on May 1st 2018 and most recently revised February 4th 2020. 180 patients are required for a single location."

Answered by AI

What types of individuals are most likely to be recruited for this research endeavor?

"This 180-person trial is open to those aged 20 and above who suffer from chronic systolic HF, LVEF of 35% or less, as well as possessing a guideline-based class I or II indication for CRT."

Answered by AI
~19 spots leftby Jan 2025