40 Participants Needed

Compression Stockings for Asthma

SB
CO
Overseen ByCristina O Francisco
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University Health Network, Toronto
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

Nocturnal worsening of asthma is common. It is characterized by overnight exacerbation of asthma symptoms such as shortness of breath, chest tightness, coughing, and wheezing, increased need of asthma medications and airway hyperresponsiveness, and decline in lung function (1). Nocturnal asthma has been attributed in part to circadian variations in lung function and airway inflammation. However, other factors including sleep, supine posture and lung volume may also contribute to nocturnal asthma. Current treatments often improve nighttime asthma symptoms. Nevertheless, nocturnal asthma is still common. Up to 2/3rd of asthma patients report nocturnal asthma symptoms, and many asthma related events occur at night, indicating poor asthma control. Results from an ongoing study suggest that in asthma while subjects were supine, fluid shifted out of the legs and accumulated in the thorax (rostral fluid shift) contributing to lower airway narrowing in asthma. A previou study has shown that wearing compression stockings during the day reduces fluid retention in the legs, reduces nocturnal rostral fluid shift out of the legs, and improves sleep apnea (2, 3). The aims of the proposed study is investigate whether off-the-shelf, below the knee compression stockings will attenuate nocturnal fluid shift and lower airway narrowing in asthma.

Do I need to stop my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

How do compression stockings differ from other asthma treatments?

Compression stockings are unique for asthma treatment as they are typically used to improve blood circulation in the legs, unlike standard asthma treatments like inhaled corticosteroids or beta-agonists, which target airway inflammation and bronchoconstriction directly.12345

Who Is on the Research Team?

AY

Azadeh Yadollahi

Principal Investigator

Scientist

Are You a Good Fit for This Trial?

This trial is for non-smokers or former smokers with less than 10 pack-years of smoking history who suffer from asthma, specifically those experiencing worsening symptoms at night. It aims to explore if wearing compression stockings can help reduce their nocturnal asthma issues.

Inclusion Criteria

I have never smoked or smoked less than 10 packs a year.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants are randomized to wear compression stockings or to control group for two weeks, with a crossover at the end of the period

2 weeks
1 visit (in-person), 1 phone call

Follow-up

Participants are monitored for changes in fluid volumes, respiratory impedance, pulmonary diffusion capacity, and lung volume after the intervention

2 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Compression Stockings
Trial Overview The study is testing the effectiveness of below-the-knee compression stockings in reducing nighttime fluid shift and airway narrowing in asthmatic patients, compared to a control group not using these stockings.
How Is the Trial Designed?
2Treatment groups
Active Control
Group I: Healthy groupActive Control2 Interventions
Group II: Asthma groupActive Control2 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

University Health Network, Toronto

Lead Sponsor

Trials
1,555
Recruited
526,000+

Published Research Related to This Trial

Immediate treatment with oral or parenteral corticosteroids is crucial for patients experiencing acute severe asthma, as benefits may take 6-12 hours to manifest, highlighting the importance of early intervention.
About 50% of acute severe asthma episodes are linked to upper respiratory infections, with other triggers including nonadherence to medication, allergen exposure, and irritant inhalation, emphasizing the need for thorough patient history and assessment of potential causes.
Chapter 14: Acute severe asthma (status asthmaticus).Shah, R., Saltoun, CA.[2018]
Asthma is a complex condition characterized by varying degrees of breathlessness and wheezing, making it challenging to define due to its broad clinical spectrum.
The reversibility of airflow obstruction, a key feature for diagnosing asthma, can be difficult to demonstrate, especially in severe cases where significant treatment time is required before improvement is observed.
Allergies, mediators and asthma.Bryant, DH.[2021]
Asthma causes airway hyperresponsiveness and bronchoconstriction, leading to symptoms like chest tightness and cough due to inflammation and smooth muscle constriction, which can occur even without significant changes in airway resistance.
Therapeutic interventions, such as beta-agonists and anti-inflammatory agents, can effectively reverse airway obstruction and improve airflow, but it's crucial to monitor changes in oxygen levels (PaO2) and carbon dioxide levels (PaCO2) to assess the severity of the condition and the effectiveness of treatment.
Physiologic diagnosis and function in asthma.Cherniack, RM.[2004]

Citations

Chapter 14: Acute severe asthma (status asthmaticus). [2018]
Allergies, mediators and asthma. [2021]
Physiologic diagnosis and function in asthma. [2004]
Pharmacotherapeutic strategies for critical asthma syndrome: a look at the state of the art. [2022]
Asthma pharmacotherapy. [2013]
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