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Genetic Counseling Chatbot for Kidney Donors

N/A
Waitlist Available
Led By Elisa J Gordon, PhD, MPH
Research Sponsored by Northwestern University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Adults (age 18 years and older)
Not cognitively impaired
Timeline
Screening 3 weeks
Treatment Varies
Follow Up post-intervention, up to 5 years
Awards & highlights

Study Summary

This trial will test whether a chatbot can help African American living kidney donors make informed decisions about their health.

Who is the study for?
This trial is for English-speaking adults over 18 who are not cognitively or vision impaired. It's specifically for transplant nephrologists evaluating live kidney donor candidates at the study sites, focusing on African American populations.Check my eligibility
What is being tested?
The trial tests a culturally adapted APOL1 genetic testing program with a chatbot named Gia and counseling training for nephrologists. It aims to improve decision-making and satisfaction among African American living kidney donors regarding donation risks.See study design
What are the potential side effects?
Since this intervention involves counseling and education rather than medication, traditional side effects aren't expected. However, there may be emotional or psychological impacts from learning about genetic risks.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am 18 years old or older.
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I am not experiencing any significant memory or thinking problems.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~post-intervention, up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and post-intervention, up to 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Number and quality of prescribed Post-Test counseling practices
Number and quality of prescribed Pre-Test counseling practices
Secondary outcome measures
Acceptability of Intervention Measure (AIM)
Clinical Sustainability Assessment Tool (CSAT)
Feasibility of Intervention Measure (FIM)
+2 more
Other outcome measures
Barriers and Facilitators to APOL1 testing Implementation
Genetic variation knowledge assessment index (GKAI)
Health Professionals Beliefs about Race (HPBR) scale
+1 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Counseling Training ProgramExperimental Treatment1 Intervention
The APOL1 counseling training program is designed for transplant nephrologists who evaluate live kidney donor candidates of African ancestry who are at risk for having APOL1 risk variants and kidney failure post-donation. The training program aims to increase transplant nephrologists' practical knowledge, self-efficacy, and skills in counseling live donor candidates about APOL1 in a culturally competent manner. The program will include training in: current APOL1 data; the value of APOL1 testing and meaning of positive test results for living donor clinical evaluation; risks of having two APOL1 gene variants on the donor's kidney health; how to engage in shared decision making about donation; how to address cultural concerns about genetic testing; and how to protect donor candidates' privacy and confidentiality with APOL1 test results. The APOL1 counseling training program will be delivered by a genetic counselor through webinars and other interactive modalities and last 2-4 hours.

Find a Location

Who is running the clinical trial?

Northwestern UniversityLead Sponsor
1,575 Previous Clinical Trials
910,591 Total Patients Enrolled
Georgetown UniversityOTHER
341 Previous Clinical Trials
126,490 Total Patients Enrolled
Elisa J Gordon, PhD, MPHPrincipal InvestigatorNorthwestern University
1 Previous Clinical Trials
8 Total Patients Enrolled

Media Library

APOL1 Counseling Training Program Clinical Trial Eligibility Overview. Trial Name: NCT04999436 — N/A
Chronic Kidney Disease Research Study Groups: Counseling Training Program
Chronic Kidney Disease Clinical Trial 2023: APOL1 Counseling Training Program Highlights & Side Effects. Trial Name: NCT04999436 — N/A
APOL1 Counseling Training Program 2023 Treatment Timeline for Medical Study. Trial Name: NCT04999436 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are participants currently being enrolled for this experiment?

"According to the information on clinicaltrials.gov, this study is not currently enrolling participants despite having been initially posted and last updated in July and September of 2022 respectively. Nevertheless, there are other 530 trials actively looking for patients right now."

Answered by AI

What is the desired outcome of this research endeavor?

"This clinical trial's principal outcome is the number and quality of prescribed post-intervention counselling practices over a maximum of 5 years. Secondary objectives include assessing acceptability, appropriateness, and feasibility through four Likert scale items that range from 1 to 5; higher scores indicating increased perceived viability for each measure."

Answered by AI
~5 spots leftby May 2025