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Behavioral Intervention

Psychosocial Therapies for Chronic Pain (MATCH Trial)

N/A

Recruiting

Led By Mark Jensen, PhD

Research Sponsored by University of Washington

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Willing to refrain from participation in any other clinical trial or interventional study for chronic pain during active participation in this study

Having chronic pain, operationalized as average pain intensity in the last week rated as ≥ 3 on a 0-10 Numerical Rating Scale (NRS) and having pain on most days for 3 months or more

Timeline

Screening 3 weeks

Treatment Varies

Follow Up assessed online up to 4 times within a 7-day period at pre-tx, 2-week, 4-week, 6-week, post-tx (8-week), and at 3- and 6-month follow-ups.

Awards & highlights

MATCH Trial Summary

This trial is researching factors that predict response to psychosocial treatments for chronic pain, such as CBT, MBCT, and HYP-CT, to develop an algorithm to match patients to the most effective treatment.

Who is the study for?

Adults over 18 with chronic pain, defined as having an average pain intensity of ≥3 on a scale of 0-10 for at least three months. Participants must speak English, have internet access for videoconferencing sessions, and be willing to avoid other clinical trials during the study. They should also be able to attend an in-person EEG assessment and use digital devices for communication.Check my eligibility

What is being tested?

The MATCH Study is testing whether Hypnotic Cognitive Therapy (HYP-CT), Mindfulness-Based Cognitive Therapy (MBCT), or Cognitive Behavioral Therapy (CBT) are effective treatments for chronic pain. It aims to identify which therapy works best based on individual patient factors like brain activity and personality traits.See study design

What are the potential side effects?

Since HYP-CT, MBCT, and CBT are psychological therapies involving counseling and mental exercises rather than drugs, they typically do not cause physical side effects. However, participants may experience emotional discomfort or increased awareness of their pain during treatment.

MATCH Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I agree not to join any other studies for chronic pain while in this trial.

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I have been in pain most days for the last 3 months, rating it 3 or higher out of 10.

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I am 18 years old or older.

MATCH Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ assessed online at pre-tx, 2-week, 4-week, 6-week, post-tx (8-week), and at 3- and 6-month follow-ups.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~assessed online at pre-tx, 2-week, 4-week, 6-week, post-tx (8-week), and at 3- and 6-month follow-ups.

This trial's timeline: 3 weeks for screening, Varies for treatment, and assessed online at pre-tx, 2-week, 4-week, 6-week, post-tx (8-week), and at 3- and 6-month follow-ups. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in Average Daily Pain Intensity

Secondary outcome measures

Change in Alcohol Use

Change in Anxiety

Change in Cannabis Use

+14 more

MATCH Trial Design

4Treatment groups

Experimental Treatment

Active Control

Group I: Mindfulness-Based Cognitive Therapy (MBCT) conditionExperimental Treatment1 Intervention

Participants randomized to this arm will be taught about the role of MBCT in training the mind to respond more adaptively to pain. This technique will help participants: (1) apply the skills they learn not only to pain but also to the problems pain causes for them, including sleep disturbance, depressed mood, stress, and other problems; (2) build on their strengths and their innate ability to focus their attention at will, and to use this ability to mindfully perceive experience in a non-judgmental, non-reactive way; and (3) notice their moment-to-moment experience and to shift their relationship to this experience. With enhanced mindful awareness comes the opportunity to then mindfully choose how to respond to the pain in a way that reduces stress and is most helpful or adaptive.

Group II: Hypnotic Cognitive Therapy (HYP-CT) conditionExperimental Treatment1 Intervention

Participants randomized to this arm will be taught about the role of hypnosis to reduce pain, increase comfort and well-being, and to instill and reinforce healthy, adaptive cognitions. This technique will help participants to use their ability to enter a state of focused attention to then increase their acceptance of new adaptive ideas about pain provided both by (1) clinicians during sessions and on audio recordings, as well as (2) the participants themselves during self-hypnosis practice.

Group III: Usual Care (UC) Control Group conditionActive Control1 Intervention

In the Usual Care condition, participants will not participate in a study treatment, but rather they will continue with their usual care for chronic pain and will complete the seven study assessment sets. At the end of the study, after the final 6-month follow-up assessment period, participants will be given the opportunity to receive any one of the three treatments that they would like as part of an open label phase of the study UNLESS participants have developed new problems that would make them ineligible.

Group IV: Cognitive Behavioral Therapy (CBT) conditionActive Control1 Intervention

Participants randomized to this arm will be taught about the role of cognitions (particularly pain catastrophizing), pain beliefs (including perceived control), and maladaptive or unhelpful coping behaviors in chronic pain. This technique will help participants: (1) identify and change or restructure unhelpful or negative thinking about pain; (2) utilize positive coping strategies including positive coping self-statements; relaxation techniques; behavioral activation (including setting goals for activation), activity pacing and scheduling; and (3) cope with pain flare-ups.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Mindfulness-Based Cognitive Therapy (MBCT)

2014

N/A

~180

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of WashingtonLead Sponsor

1,740 Previous Clinical Trials

1,847,370 Total Patients Enrolled

40 Trials studying Chronic Pain

17,047 Patients Enrolled for Chronic Pain

National Center for Complementary and Integrative Health (NCCIH)NIH

832 Previous Clinical Trials

668,634 Total Patients Enrolled

45 Trials studying Chronic Pain

17,679 Patients Enrolled for Chronic Pain

VA Puget Sound Health Care SystemFED

65 Previous Clinical Trials

227,492 Total Patients Enrolled

3 Trials studying Chronic Pain

581 Patients Enrolled for Chronic Pain

Media Library

Cognitive Behavioral Therapy (CBT) (Behavioral Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT05699252 — N/A

Chronic Pain Research Study Groups: Hypnotic Cognitive Therapy (HYP-CT) condition, Mindfulness-Based Cognitive Therapy (MBCT) condition, Usual Care (UC) Control Group condition, Cognitive Behavioral Therapy (CBT) condition

Chronic Pain Clinical Trial 2023: Cognitive Behavioral Therapy (CBT) Highlights & Side Effects. Trial Name: NCT05699252 — N/A

Cognitive Behavioral Therapy (CBT) (Behavioral Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05699252 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the total population size of participants engaging in this research study?

"Affirmative. The clinicaltrials.gov database indicates that this research endeavour is currently seeking participants; it was initially posted on March 1, 2023 and the most recent update occurred on March 17th, 2023. This examination necessitates 300 volunteers from 3 respective sites."

Answered by AI

Is this trial currently open for enrollment?

"Clinicaltrials.gov confirms that recruitment is ongoing for this research, which was first made available on the 1st of March and last updated a little over two weeks later."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Matching Adults to Treatments for Chronic Pain (MATCH) Study

Mark Jensen 2023. "Matching Adults to Treatments for Chronic Pain (MATCH) Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05699252.

All > American Chronic Pain