Short-Course Antibiotics for Childhood Pneumonia
(PRESTO-2 Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
Children are commonly hospitalized because of community-acquired pneumonia (CAP). There are multiple high-quality randomized trials of short-course antibiotic therapy (3-5 days of treatment) for adults hospitalized with CAP - but there is very little evidence in children. We intend to do a pilot RCT of short-course (3-5 days) vs standard-duration (8-10 days) antibiotic therapy for children hospitalized for CAP.
Will I have to stop taking my current medications?
The trial requires that children stop taking coumadin-based anticoagulants and tetracycline-type antibiotics due to potential interactions with the study medication, amoxicillin.
Is amoxicillin safe for treating childhood pneumonia?
How is the drug amoxicillin unique in treating childhood pneumonia?
What data supports the effectiveness of the drug Amoxicillin for treating childhood pneumonia?
Research shows that Amoxicillin is recommended by the World Health Organization as the best first-line treatment for non-severe childhood pneumonia, given twice daily for 3-5 days. Additionally, a study found no significant difference in effectiveness between Amoxicillin and another antibiotic, co-trimoxazole, for treating non-severe pneumonia in children.458910
Are You a Good Fit for This Trial?
This trial is for children hospitalized with community-acquired pneumonia (CAP) who show signs like fast breathing, coughing, and increased effort to breathe. They must have physical exam findings that match CAP. Children without these specific symptoms or other criteria will not be eligible.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either short-course (3-5 days) or standard-duration (8-10 days) antibiotic therapy for community-acquired pneumonia
Follow-up
Participants are monitored for safety and effectiveness after treatment, including assessment of late clinical response and development of complicated pneumonia
What Are the Treatments Tested in This Trial?
Interventions
- Amoxicillin
Amoxicillin is already approved in European Union, United States, Canada for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
Jeffrey Pernica
Lead Sponsor
Jeffrey
Lead Sponsor