PATH-Pain for Cognitive Impairment

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Cognitive Impairment+2 MorePATH-Pain - Behavioral
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This trial will study if a problem-focused adaptation therapy can help improve cognitive functioning, depression, and pain-related disability in 100 older adults with cognitive impairment, chronic pain, and depression.

Eligible Conditions
  • Cognitive Impairment
  • Pain
  • Depression

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

1 Primary · 3 Secondary · Reporting Duration: Baseline, Weeks 5, 9, 24, 36, 52

Week 5
Change in depressive symptoms, as measured by the Montgomery-Asberg Depression Rating Scale (MADRS)
Change in pain-related disability, as measured by the Roland-Morris Scale
Week 9
Change in cognition, as measured by the Alzheimer's Disease Assessment Scale - Cognition Subscale (ADAS-COG)
Change in cognitive functioning, as measured by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)

Trial Safety

Safety Progress

1 of 3

Trial Design

2 Treatment Groups

Attention Control Usual Care
1 of 2
Problem Adaptation Therapy for Pain (PATH-Pain)
1 of 2

Active Control

Experimental Treatment

100 Total Participants · 2 Treatment Groups

Primary Treatment: PATH-Pain · No Placebo Group · N/A

Problem Adaptation Therapy for Pain (PATH-Pain)
Behavioral
Experimental Group · 1 Intervention: PATH-Pain · Intervention Types: Behavioral
Attention Control Usual CareNoIntervention Group · 1 Intervention: Attention Control Usual Care · Intervention Types:

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: baseline, weeks 5, 9, 24, 36, 52

Who is running the clinical trial?

National Institute on Aging (NIA)NIH
1,414 Previous Clinical Trials
3,484,122 Total Patients Enrolled
Weill Medical College of Cornell UniversityLead Sponsor
989 Previous Clinical Trials
1,338,830 Total Patients Enrolled
Mannigton C Reid, MDPrincipal InvestigatorWeill Medical College of Cornell University
Dimitris Kiosses, PhDPrincipal InvestigatorWeill Medical College of Cornell University
6 Previous Clinical Trials
575 Total Patients Enrolled
Lisa Ravdin, PhDPrincipal InvestigatorWeill Medical College of Cornell University

Eligibility Criteria

Age 18+ · All Participants · 8 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have a clinical dementia rating of 0.5 or 1.
You have chronic pain (neuropathic, nociceptive or mixed disorders).