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Superior laryngeal nerve block for Cough

Phase 2
Waitlist Available
Led By Courtney Tipton
Research Sponsored by Medical University of South Carolina
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up every two weeks (+/- 1 week) post-treatment (estimated 3 months total), 3 months post completion of therapy
Awards & highlights

Study Summary

This trial is to study if superior laryngeal nerve blocks can help reduce coughs better than a placebo. Eligible patients are over 18, have a history of coughs, and are non-smokers. The study will follow patients over time and randomly assign them to either the treatment or placebo group. The treatment group will get four superior laryngeal nerve blocks, and the placebo group will get four saline injections. The study team will measure if the injection improved cough and ask patients to keep a log of symptoms and fill out questionnaires at each visit. After the four injections, patients will follow up in 3 months to see if

Eligible Conditions
  • Cough
  • Superior Laryngeal Nerve Block
  • Neurogenic Cough

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, every two weeks (+/- 1 week) post-treatment (estimated 3 months total)
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, every two weeks (+/- 1 week) post-treatment (estimated 3 months total) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in cough severity
Secondary outcome measures
Coughing
Subjective improvement in cough

Side effects data

From 2014 Phase 4 trial • 40 Patients • NCT01602692
40%
Nausea
10%
Vomiting
100%
80%
60%
40%
20%
0%
Study treatment Arm
Tumescent Solution With Dilute Epinephrine
Tumescent Solution With Dilute Lidocaine and Epinephrine

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Steroid-Lidocaine MixtureExperimental Treatment2 Interventions
Will receive numbing injection, which is a mixture of steroid and lidocaine
Group II: PlaceboPlacebo Group2 Interventions
Will receive saline injection as a placebo
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Superior laryngeal nerve block
2020
Completed Phase 2
~20
Injection of steroid-lidocaine mixture
2020
Completed Phase 2
~20

Find a Location

Who is running the clinical trial?

Medical University of South CarolinaLead Sponsor
932 Previous Clinical Trials
7,394,371 Total Patients Enrolled
Courtney TiptonPrincipal Investigator - Medical University of South Carolina
MUSC Children's Hospital, Medical University of South Carolina

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are we still looking for participants for this experiment?

"Yes, this information is accurate. The trial's most recent update was on November 10th, 2020 and it is still recruiting patients for participation."

Answered by AI

What is the governmental stance on Superior laryngeal nerve block?

"Superior laryngeal nerve block is considered safe, but there is no data supporting its efficacy. Our team at Power estimates the safety of Superior laryngeal nerve block to be a 2 because this is a Phase 2 trial."

Answered by AI

What is the highest patient count that this research can include?

"The latest information available on clinicaltrials.gov does show that this trial is still recruiting patients. This particular study was posted on 7/22/2020 and updated as recently as 11/10/2022. They are looking for 50 individuals total, across 1 site."

Answered by AI

Who else is applying?

What site did they apply to?
Medical University of South Carolina
What portion of applicants met pre-screening criteria?
Met criteria

Why did patients apply to this trial?

Dealing with a severe chronic cough that does not respond to any interventions for the past several years.
PatientReceived 2+ prior treatments
Recent research and studies
clinicaltrials.govStudy
Efficacy of SLN Block for Chronic Cough
Courtney Tipton 2020. "Efficacy of SLN Block for Chronic Cough". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04421092.
~4 spots leftby Apr 2025
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