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Superior laryngeal nerve block for Cough

Phase 2
Waitlist Available
Led By Courtney Tipton
Research Sponsored by Medical University of South Carolina
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, every two weeks (+/- 1 week) post-treatment (estimated 3 months total)

Summary

This trial is testing if injections near a specific throat nerve can reduce coughing in adults with an overactive nerve. Participants will receive either the actual treatment or a non-active treatment. The goal is to see if these injections can help lessen their cough.

Eligible Conditions
  • Cough
  • Superior Laryngeal Nerve Block
  • Neurogenic Cough

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~every two weeks (+/- 1 week) post-treatment (estimated 3 months total), 3 months post completion of therapy
This trial's timeline: 3 weeks for screening, Varies for treatment, and every two weeks (+/- 1 week) post-treatment (estimated 3 months total), 3 months post completion of therapy for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in cough severity
Secondary study objectives
Coughing
Subjective improvement in cough

Side effects data

From 2014 Phase 4 trial • 40 Patients • NCT01602692
40%
Nausea
10%
Vomiting
100%
80%
60%
40%
20%
0%
Study treatment Arm
Tumescent Solution With Dilute Epinephrine
Tumescent Solution With Dilute Lidocaine and Epinephrine

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Steroid-Lidocaine MixtureExperimental Treatment2 Interventions
Will receive numbing injection, which is a mixture of steroid and lidocaine
Group II: PlaceboPlacebo Group2 Interventions
Will receive saline injection as a placebo
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Superior laryngeal nerve block
2020
Completed Phase 2
~20
Injection of steroid-lidocaine mixture
2020
Completed Phase 2
~20

Find a Location

Who is running the clinical trial?

Medical University of South CarolinaLead Sponsor
966 Previous Clinical Trials
7,399,601 Total Patients Enrolled
1 Trials studying Cough
40 Patients Enrolled for Cough
Courtney TiptonPrincipal Investigator - Medical University of South Carolina
MUSC Children's Hospital, Medical University of South Carolina
~4 spots leftby Oct 2025
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