Rhofade

Nasal Intubation, Rhinorrhea, Rhinitis, Allergic + 10 more

Treatment

3 FDA approvals

20 Active Studies for Rhofade

What is Rhofade

Oxymetazoline

The Generic name of this drug

Treatment Summary

Oxymetazoline is a medication that works by stimulating alpha-adrenergic receptors. It is available in various formulations and is used to treat facial redness, nasal congestion, and acquired blepharoptosis (ptosis). OTC intranasal sprays are used to relieve symptoms of the common cold, hay fever, and other upper respiratory allergies. Oxymetazoline is also used for regional anesthesia during dental procedures in both children and adults. In July 2020, the FDA approved the use of an ophthalmic formulation of oxymetazoline for the first time.

Afrin Original Pump Mist

is the brand name

image of different drug pills on a surface

Rhofade Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Afrin Original Pump Mist

Oxymetazoline

1975

7

Approved as Treatment by the FDA

Oxymetazoline, commonly known as Afrin Original Pump Mist, is approved by the FDA for 3 uses including Anesthesia, Conduction and Obesity .

Anesthesia, Conduction

Used to treat induction of Regional Anesthesia in combination with Tetracaine

Obesity

Used to treat weight 40 kg or more in combination with Tetracaine

Anesthesia, Conduction

Used to treat Regional Anesthesia therapy in combination with Tetracaine

Effectiveness

How Rhofade Affects Patients

Oxymetazoline is a medication that helps to narrow the blood vessels, reducing blood flow. It has a strong affinity for two types of adrenergic receptors (α1A- and α2B-adrenoceptors) and has a long-lasting effect when used intranasally to relieve nasal congestion. Studies have also shown that oxymetazoline has antioxidant properties, which helps protect cells from damage caused by oxidants related to inflammation.

How Rhofade works in the body

Oxymetazoline works by activating certain receptors on the cells in the body. This triggers a reaction that causes the muscles to contract, and promotes constriction of the blood vessels. This reduces swelling and inflammation in the area. This drug is commonly used to treat redness on the face due to rosacea, to lift drooping eyelids, and to reduce nasal congestion. It is also often used in combination with other drugs for local anesthesia in dentistry, to counteract the vasodilatory effects of the anesthesia.

When to interrupt dosage

The suggested dosage of Rhofade is contingent upon the determined condition, including Regional Anesthesia, weight 40 kg or more and Hay Fever. The dosage amount is contingent upon the technique of delivery (e.g. Solution - Nasal or Solution) featured in the table beneath.

Condition

Dosage

Administration

Sinus Congestion

, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL

, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Solution / drops - Ophthalmic, Kit - Topical, Jelly, Jelly - Nasal

Postoperative Hemorrhage

, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL

, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Solution / drops - Ophthalmic, Kit - Topical, Jelly, Jelly - Nasal

Nasal Intubation

, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL

, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Solution / drops - Ophthalmic, Kit - Topical, Jelly, Jelly - Nasal

Rhinorrhea

, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL

, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Solution / drops - Ophthalmic, Kit - Topical, Jelly, Jelly - Nasal

Rhinitis, Allergic

, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL

, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Solution / drops - Ophthalmic, Kit - Topical, Jelly, Jelly - Nasal

Obesity

, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL

, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Solution / drops - Ophthalmic, Kit - Topical, Jelly, Jelly - Nasal

Nasal Congestion

, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL

, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Solution / drops - Ophthalmic, Kit - Topical, Jelly, Jelly - Nasal

Acquired Blepharoptosis

, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL

, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Solution / drops - Ophthalmic, Kit - Topical, Jelly, Jelly - Nasal

Anesthesia, Conduction

, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL

, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Solution / drops - Ophthalmic, Kit - Topical, Jelly, Jelly - Nasal

Rosacea

, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL

, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Solution / drops - Ophthalmic, Kit - Topical, Jelly, Jelly - Nasal

Anesthesia, Conduction

, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL

, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Solution / drops - Ophthalmic, Kit - Topical, Jelly, Jelly - Nasal

Airway visualization

, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL

, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Solution / drops - Ophthalmic, Kit - Topical, Jelly, Jelly - Nasal

persistent facial erythema

, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL

, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Solution / drops - Ophthalmic, Kit - Topical, Jelly, Jelly - Nasal

Warnings

Rhofade has one recognized contraindication, so it should not be utilized in conjunction with the conditions given in the following table.

Rhofade Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Oxymetazoline may interact with Pulse Frequency

There are 20 known major drug interactions with Rhofade.

Common Rhofade Drug Interactions

Drug Name

Risk Level

Description

Antazoline

Major

The absorption of Antazoline can be decreased when combined with Oxymetazoline.

Azelastine

Major

The absorption of Azelastine can be decreased when combined with Oxymetazoline.

Beclomethasone dipropionate

Major

The absorption of Beclomethasone dipropionate can be decreased when combined with Oxymetazoline.

Betamethasone

Major

The absorption of Betamethasone can be decreased when combined with Oxymetazoline.

Budesonide

Major

The absorption of Budesonide can be decreased when combined with Oxymetazoline.

Rhofade Toxicity & Overdose Risk

In rats, the toxic dose of oxymetazoline is 680 micrograms/kg when taken orally and 1630 micrograms/kg when taken subcutaneously. In mice, the toxic dose is 4700 micrograms/kg when taken orally, 48 milligrams/kg when taken intraperitoneally, and 34 milligrams/kg when taken subcutaneously. People who overdose on oxymetazoline may experience dizziness, chest pain, headaches, heart attack or stroke, vision problems, abnormal heart rhythm, high or low blood pressure, drowsiness, widening of the pupils, hypothermia,

image of a doctor in a lab doing drug, clinical research

Rhofade Novel Uses: Which Conditions Have a Clinical Trial Featuring Rhofade?

13 active clinical trials are currently examining the potential of Rhofade to alleviate Nasal Congestion, Conduction Anesthesia and Ear Structure.

Condition

Clinical Trials

Trial Phases

Postoperative Hemorrhage

7 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3

persistent facial erythema

0 Actively Recruiting

Rhinorrhea

0 Actively Recruiting

Anesthesia, Conduction

0 Actively Recruiting

Rosacea

0 Actively Recruiting

Acquired Blepharoptosis

0 Actively Recruiting

Anesthesia, Conduction

0 Actively Recruiting

Airway visualization

0 Actively Recruiting

Nasal Congestion

0 Actively Recruiting

Rhinitis, Allergic

0 Actively Recruiting

Nasal Intubation

0 Actively Recruiting

Obesity

638 Actively Recruiting

Not Applicable, Phase 2, Phase 4, Phase 1, Early Phase 1, Phase 3

Sinus Congestion

0 Actively Recruiting

Rhofade Reviews: What are patients saying about Rhofade?

5

Patient Review

11/10/2019

Rhofade for Acne Rosacea

I had tried a number of topical treatments from my dermotologist, such as Mirvaso, Desonide Lotion, Finacea and Metronidazole cream, before trying Rhofade. This one did the trick; it is amazing. I had terribly hot red skin that would show up after around noon during the day, but one application of Rhofade in the morning after my shower moisturizes and keeps the rosecea redness away from ever appearing ALL DAY. It was a miracle-- though very expensive, it was well worth it.

5

Patient Review

2/2/2022

Rhofade for Acne Rosacea

I've used Mirvaso in the past and had terrible rebound flushing, but Rhofade doesn't have that same problem. In fact, it might have even helped with the redness permanently!
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about rhofade

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does Rhofade help rosacea?

"The drug Rhofade is used to treat rosacea by reducing the size of the blood vessels near the surface of the skin. This helps to reduce the amount of blood flow through these vessels and decreases the facial redness associated with the condition."

Answered by AI

Can Rhofade make rosacea worse?

"The most common side effects when using RHOFADE® cream include dermatitis, worsening of rosacea pimples, itching, redness, and pain."

Answered by AI

How long does it take Rhofade to work?

"Rhofade works to reduce facial redness within 3 hours of first use for up to 11.6% of patients. With regular use over the course of one year, 36.7% of patients have a 2-grade or greater improvement in their redness score when measured 3 hours after Rhofade has been applied."

Answered by AI

What does Rhofade do for your face?

"The medication oxymetazoline is used to treat the skin disorder rosacea by narrowing the blood vessels in the face. Oxymetazoline belongs to a class of drugs known as a sympathomimetic (alpha receptor agonist), which may help to decrease facial redness caused by rosacea."

Answered by AI

Clinical Trials for Rhofade

Image of VA Greater Los Angeles Healthcare System, West Los Angeles, CA in West Los Angeles, United States.

EBQI Strategies for Women's Health

Any Age
All Sexes
West Los Angeles, CA

Women Veterans are the fastest growing segment of VA users, with most users in midlife. This dramatic growth has created challenges for VA to ensure that appropriate services are available to meet women Veterans' needs, and that they will want and be able to use those services. Furthermore, few VA improvement efforts have focused on women Veterans' health and health care in midlife. The EMPOWER QUERI 3.0 Program is a cluster randomized type 3 hybrid implementation-effectiveness trial testing two strategies designed to support implementation and sustainment of evidence-based practices for women Veterans in at least 18 VA facilities from 4 regions.

Waitlist Available
Has No Placebo

VA Greater Los Angeles Healthcare System, West Los Angeles, CA

Alison B Hamilton, PhD MPH

Image of Brigham and Womens Hospital in Boston, United States.

Chia Seeds for Breastfeeding

18 - 45
All Sexes
Boston, MA

The investigators' over-arching hypothesis is that mechanical and compositional properties of chia seeds supplemented during lactation diminish obesity-induced intestinal inflammation and barrier dysfunction. The investigators hypothesize these changes will result in: 1) reduced maternal systemic inflammation (serum CRP and IL-6) and increased gut microbial diversity and richness, 2) reduced HM fat and inflammatory markers, metrics the research team have demonstrated differ in tandem with maternal metabolic health and 3) improved infant growth/body composition. To test these hypotheses, investigators will evaluate chia seed supplementation during lactation in a 6wk multi-site pilot RCT (Aim 1) and through translational studies using human enteroids (Aim 2).

Waitlist Available
Has No Placebo

Brigham and Womens Hospital (+1 Sites)

David A Fields, Phd

Have you considered Rhofade clinical trials?

We made a collection of clinical trials featuring Rhofade, we think they might fit your search criteria.
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Image of Public Health Research Center: Clinical Exercise Research Center in Columbia, United States.

Pistachio Snacking for Obesity

25 - 45
All Sexes
Columbia, SC

The purpose of this study is to evaluate the effects of pistachio snacking on metabolic flexibility (at rest, during exercise, and in post-exercise recovery) in healthy overweight and obese adults. Secondary goals include evaluating effects on changes in diet quality, sleep characteristics, physical activity, and hormonal health in women. In randomized order, participants will complete four days of pistachio snacking and four days of normal dietary habits (control). For both conditions, primary outcomes of resting substrate metabolism, metabolic flexibility during exercise, and post-exercise substrate metabolism will be measured pre-post intervention via indirect calorimetry. Secondary outcome of diet quality (kcal, carb, fat, protein) will be measured pre-post intervention via diet log. Exploratory outcomes of daily physical activity (steps, intensity), nightly sleep characteristics (quantity, quality, latency, efficiency), and daytime sleepiness and hunger.

Recruiting
Has No Placebo

Public Health Research Center: Clinical Exercise Research Center

Katie R Hirsch, PhD

Image of People Science in Los Angeles, United States.

CLB101 for Gut Health in Obesity

18 - 65
All Sexes
Los Angeles, CA

Anaerostipes caccae CLB101TM️ is a next-generation probiotic isolated from healthy humans. It was shown to be in decreased abundance in people with protein-based food sensitivities/allergies. CLB101TM️ is different from most commercially available probiotics in that it directly produces butyrate. Butyrate is a naturally occurring small molecule found in the gut of healthy individuals, and it has been shown to provide clinical benefits including strengthening the gut lining, providing immune health, and supporting a balanced microbiome. The rationale for developing CLB101TM️ is to provide a probiotic that generates butyrate in the targeted intestinal locations where it can optimally benefit cells that line the gut.

Waitlist Available
Paid Trial

People Science

Naoh Craft, MD

ClostraBio Inc.

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We made a collection of clinical trials featuring Rhofade, we think they might fit your search criteria.
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Image of Miles Square Health Center Chicago in Chicago, United States.

Food is Medicine for High Blood Pressure and Obesity

Any Age
All Sexes
Chicago, IL

The goal of this clinical trial is to treat both hypertension and obesity in adults using a food is medicine framework. Participants will be randomized 1:1 to FIM+DASH or usual-care control. The 24-week trial includes a 12-week FIM+DASH intervention followed by a 12-week maintenance period and leverages existing partnerships with community-based organizations for home food delivery and culinary skill-skill building. The main questions it aims to answer are: (1) What is the effect of FIM+DASH vs. usual care control on blood pressure? (2) What is the effect of FIM+DASH vs. usual care control on DASH diet adherence (diet quality), body weight, and waist circumference? (3) How to identify factors associated with the sustainability and scalability of FIM+DASH in real-world settings?

Phase 2
Waitlist Available

Miles Square Health Center Chicago (+3 Sites)

Image of Local Restaurant Site in Bryan, United States.

Menu Labeling for Healthy Habits and Diet

18+
All Sexes
Bryan, TX

This study evaluates the impact of culturally tailored menu labeling interventions on psychosocial factors and ordering behavior among customers in two independently owned Hispanic restaurants in East-Central Texas. Participants will be exposed to one of three sequential menu conditions at each restaurant: (1) a standard menu without nutrition information, (2) a paper menu with bilingual nutrition labels, or (3) a digital menu app enhanced with Augmented Reality (AR) and Artificial Intelligence (AI) providing interactive nutrition guidance. The study will assess whether menu formats influence nutrition literacy, decision-making confidence, self-efficacy, attitudes, behavioral intentions, and actual ordering behavior. Data will be collected through surveys, purchase receipts, and app interaction logs.

Recruiting
Has No Placebo

Local Restaurant Site

Hyunjung Lee, PhD

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We made a collection of clinical trials featuring Rhofade, we think they might fit your search criteria.
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