Rhofade
Nasal Intubation, Rhinorrhea, Rhinitis, Allergic + 10 more
Treatment
3 FDA approvals
6 Active Studies for Rhofade
Treatment for
Nasal Intubation
What is Rhofade
Oxymetazoline
The Generic name of this drug
Treatment Summary
Oxymetazoline is a medication that works by stimulating alpha-adrenergic receptors. It is available in various formulations and is used to treat facial redness, nasal congestion, and acquired blepharoptosis (ptosis). OTC intranasal sprays are used to relieve symptoms of the common cold, hay fever, and other upper respiratory allergies. Oxymetazoline is also used for regional anesthesia during dental procedures in both children and adults. In July 2020, the FDA approved the use of an ophthalmic formulation of oxymetazoline for the first time.
Afrin Original Pump Mist
is the brand name
Rhofade Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Afrin Original Pump Mist
Oxymetazoline
1975
7
Approved as Treatment by the FDA
Oxymetazoline, commonly known as Afrin Original Pump Mist, is approved by the FDA for 3 uses including Anesthesia, Conduction and Obesity .
Anesthesia, Conduction
Used to treat induction of Regional Anesthesia in combination with Tetracaine
Obesity
Used to treat weight 40 kg or more in combination with Tetracaine
Anesthesia, Conduction
Used to treat Regional Anesthesia therapy in combination with Tetracaine
Effectiveness
How Rhofade Affects Patients
Oxymetazoline is a medication that helps to narrow the blood vessels, reducing blood flow. It has a strong affinity for two types of adrenergic receptors (α1A- and α2B-adrenoceptors) and has a long-lasting effect when used intranasally to relieve nasal congestion. Studies have also shown that oxymetazoline has antioxidant properties, which helps protect cells from damage caused by oxidants related to inflammation.
How Rhofade works in the body
Oxymetazoline works by activating certain receptors on the cells in the body. This triggers a reaction that causes the muscles to contract, and promotes constriction of the blood vessels. This reduces swelling and inflammation in the area. This drug is commonly used to treat redness on the face due to rosacea, to lift drooping eyelids, and to reduce nasal congestion. It is also often used in combination with other drugs for local anesthesia in dentistry, to counteract the vasodilatory effects of the anesthesia.
When to interrupt dosage
The suggested dosage of Rhofade is contingent upon the determined condition, including Regional Anesthesia, weight 40 kg or more and Hay Fever. The dosage amount is contingent upon the technique of delivery (e.g. Solution - Nasal or Solution) featured in the table beneath.
Condition
Dosage
Administration
Sinus Congestion
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Liquid - Nasal, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal, Oral, Spray - Oral
Postoperative Hemorrhage
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Liquid - Nasal, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal, Oral, Spray - Oral
Nasal Intubation
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Liquid - Nasal, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal, Oral, Spray - Oral
Rhinorrhea
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Liquid - Nasal, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal, Oral, Spray - Oral
Rhinitis, Allergic
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Liquid - Nasal, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal, Oral, Spray - Oral
Obesity
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Liquid - Nasal, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal, Oral, Spray - Oral
Nasal Congestion
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Liquid - Nasal, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal, Oral, Spray - Oral
Acquired Blepharoptosis
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Liquid - Nasal, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal, Oral, Spray - Oral
Anesthesia, Conduction
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Liquid - Nasal, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal, Oral, Spray - Oral
Rosacea
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Liquid - Nasal, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal, Oral, Spray - Oral
Anesthesia, Conduction
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Liquid - Nasal, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal, Oral, Spray - Oral
Airway visualization
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Liquid - Nasal, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal, Oral, Spray - Oral
persistent facial erythema
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Solution / drops, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Liquid - Nasal, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal, Oral, Spray - Oral
Warnings
Rhofade has one recognized contraindication, so it should not be utilized in conjunction with the conditions given in the following table.
Rhofade Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Oxymetazoline may interact with Pulse Frequency
There are 20 known major drug interactions with Rhofade.
Common Rhofade Drug Interactions
Drug Name
Risk Level
Description
Antazoline
Major
The absorption of Antazoline can be decreased when combined with Oxymetazoline.
Azelastine
Major
The absorption of Azelastine can be decreased when combined with Oxymetazoline.
Beclomethasone dipropionate
Major
The absorption of Beclomethasone dipropionate can be decreased when combined with Oxymetazoline.
Betamethasone
Major
The absorption of Betamethasone can be decreased when combined with Oxymetazoline.
Budesonide
Major
The absorption of Budesonide can be decreased when combined with Oxymetazoline.
Rhofade Toxicity & Overdose Risk
In rats, the toxic dose of oxymetazoline is 680 micrograms/kg when taken orally and 1630 micrograms/kg when taken subcutaneously. In mice, the toxic dose is 4700 micrograms/kg when taken orally, 48 milligrams/kg when taken intraperitoneally, and 34 milligrams/kg when taken subcutaneously. People who overdose on oxymetazoline may experience dizziness, chest pain, headaches, heart attack or stroke, vision problems, abnormal heart rhythm, high or low blood pressure, drowsiness, widening of the pupils, hypothermia,
Rhofade Novel Uses: Which Conditions Have a Clinical Trial Featuring Rhofade?
13 active clinical trials are currently examining the potential of Rhofade to alleviate Nasal Congestion, Conduction Anesthesia and Ear Structure.
Condition
Clinical Trials
Trial Phases
Postoperative Hemorrhage
6 Actively Recruiting
Not Applicable, Phase 2, Phase 3
persistent facial erythema
0 Actively Recruiting
Rhinorrhea
0 Actively Recruiting
Anesthesia, Conduction
0 Actively Recruiting
Rosacea
0 Actively Recruiting
Acquired Blepharoptosis
0 Actively Recruiting
Anesthesia, Conduction
0 Actively Recruiting
Airway visualization
0 Actively Recruiting
Nasal Congestion
0 Actively Recruiting
Rhinitis, Allergic
0 Actively Recruiting
Nasal Intubation
0 Actively Recruiting
Obesity
0 Actively Recruiting
Sinus Congestion
0 Actively Recruiting
Rhofade Reviews: What are patients saying about Rhofade?
5
Patient Review
11/10/2019
Rhofade for Acne Rosacea
5
Patient Review
2/2/2022
Rhofade for Acne Rosacea
Patient Q&A Section about rhofade
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Does Rhofade help rosacea?
"The drug Rhofade is used to treat rosacea by reducing the size of the blood vessels near the surface of the skin. This helps to reduce the amount of blood flow through these vessels and decreases the facial redness associated with the condition."
Answered by AI
How long does it take Rhofade to work?
"Rhofade works to reduce facial redness within 3 hours of first use for up to 11.6% of patients. With regular use over the course of one year, 36.7% of patients have a 2-grade or greater improvement in their redness score when measured 3 hours after Rhofade has been applied."
Answered by AI
What does Rhofade do for your face?
"The medication oxymetazoline is used to treat the skin disorder rosacea by narrowing the blood vessels in the face. Oxymetazoline belongs to a class of drugs known as a sympathomimetic (alpha receptor agonist), which may help to decrease facial redness caused by rosacea."
Answered by AI