Experimental: Long-term activity-based training with non-invasive spinal cord stimulation for Spinal Cord Injuries

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Washington University, Saint Louis, MO
Spinal Cord Injuries
Electrophysiology assessment - corticospinal tract - Other
Eligibility
Any Age
All Sexes
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Study Summary

This study will help the investigators better understand the changes in short-term excitability and long-term plasticity of corticospinal, reticulospinal and spinal neural circuits and how the changes impact the improvements of spinal cord stimulation (SCS) mediated motor function.

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

3 Primary · 2 Secondary · Reporting Duration: 30 minutes before and 30 minutes after intervention; 4 weeks

Week 4
F-wave response persistence
Motor evoked potentials amplitude and latency
Reaction time to startle response
Week 4
Change in movement smoothness
Changes in time to completion from baseline

Trial Safety

Trial Design

6 Treatment Groups

Experimental: Long-term activity-based training with non-invasive spinal cord st...
1 of 6
Experimental: Non-invasive spinal cord stimulation and strength training
1 of 6
Experimental: Activity-based training
1 of 6
Experimental: Non-invasive spinal cord stimulation and precision training
1 of 6
Experimental: Non-invasive spinal cord stimulation
1 of 6
Experimental: Activity-based training wtih non-invasive spinal cord stimulation
1 of 6
Experimental Treatment

120 Total Participants · 6 Treatment Groups

Primary Treatment: Experimental: Long-term activity-based training with non-invasive spinal cord stimulation · No Placebo Group · N/A

Experimental: Long-term activity-based training with non-invasive spinal cord stimulationExperimental Group · 5 Interventions: Electrophysiology assessment - corticospinal tract, Transcutaneous spinal cord stimulation, Activity-based training, Electrophysiology assessment - spinal motoneuron, Electrophysiology assessment - reticulospinal tract · Intervention Types: Other, Other, Other, Other, Other
Experimental: Non-invasive spinal cord stimulation and strength trainingExperimental Group · 5 Interventions: Electrophysiology assessment - corticospinal tract, Transcutaneous spinal cord stimulation, Activity-based training, Electrophysiology assessment - spinal motoneuron, Electrophysiology assessment - reticulospinal tract · Intervention Types: Other, Other, Other, Other, Other
Experimental: Activity-based trainingExperimental Group · 4 Interventions: Electrophysiology assessment - corticospinal tract, Activity-based training, Electrophysiology assessment - spinal motoneuron, Electrophysiology assessment - reticulospinal tract · Intervention Types: Other, Other, Other, Other
Experimental: Non-invasive spinal cord stimulation and precision trainingExperimental Group · 5 Interventions: Electrophysiology assessment - corticospinal tract, Transcutaneous spinal cord stimulation, Activity-based training, Electrophysiology assessment - spinal motoneuron, Electrophysiology assessment - reticulospinal tract · Intervention Types: Other, Other, Other, Other, Other
Experimental: Non-invasive spinal cord stimulationExperimental Group · 4 Interventions: Electrophysiology assessment - corticospinal tract, Transcutaneous spinal cord stimulation, Electrophysiology assessment - spinal motoneuron, Electrophysiology assessment - reticulospinal tract · Intervention Types: Other, Other, Other, Other
Experimental: Activity-based training wtih non-invasive spinal cord stimulationExperimental Group · 5 Interventions: Electrophysiology assessment - corticospinal tract, Transcutaneous spinal cord stimulation, Activity-based training, Electrophysiology assessment - spinal motoneuron, Electrophysiology assessment - reticulospinal tract · Intervention Types: Other, Other, Other, Other, Other

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 30 minutes before and 30 minutes after intervention; 4 weeks

Trial Background

Prof. Ismael Seáñez, Assistant Professor of Biomedical Engineering and Neurosurgery
Principal Investigator
Washington University School of Medicine
Closest Location: Washington University · Saint Louis, MO
Photo of university of washington  1Photo of university of washington  2Photo of university of washington  3
2008First Recorded Clinical Trial
8 TrialsResearching Spinal Cord Injuries
512 CompletedClinical Trials

Eligibility Criteria

Age Any Age · All Participants · 3 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
You must be between 16 and 65 years old.
You are not a patient with any major comorbidities of any organ system.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.