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Ultrasound

LIFUP Neuromodulation for Healthy Controls

N/A
Waitlist Available
Led By Sudhakar Selvaraj, MD,PhD
Research Sponsored by The University of Texas Health Science Center, Houston
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 1 day
Treatment Varies
Follow Up baseline, 5 mins post-lifup sonication
Awards & highlights

Study Summary

This trial will study the effect of LIFUP on emotion processing, and whether it is safe to use on healthy volunteers.

Who is the study for?
This trial is for right-handed, healthy individuals who are not on drugs or psychotropic medications and have no chronic medical, psychiatric, or neurological illnesses. Women cannot be pregnant or nursing. Participants must also be comfortable with MRI scans and free from claustrophobia.Check my eligibility
What is being tested?
The study is testing the effects of a technique called LIFUP sonication to the amygdala on emotion processing in healthy people. It aims to understand how this low-intensity focused ultrasound can stimulate or inhibit brain activity safely.See study design
What are the potential side effects?
While the trial assesses safety, potential side effects may include discomfort at the site of sonication, headache, nausea, or other unknown risks associated with stimulating brain activity using ultrasound.

Timeline

Screening ~ 1 day
Treatment ~ Varies
Follow Up ~baseline, 10-20 mins post-lifup sonication
This trial's timeline: 1 day for screening, Varies for treatment, and baseline, 10-20 mins post-lifup sonication for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Changes in amygdala activity indicated by functional magnetic resonance imaging (fMRI) scan blood oxygen-level-dependent (BOLD) signal
Changes in brain resting state functional network as indicated by fMRI scan connectivity measures
Secondary outcome measures
Change in performance on Reward Task
Tolerability of LIFUP sonication as assessed number of adverse events

Trial Design

1Treatment groups
Experimental Treatment
Group I: LIFUP sonication to the amygdalaExperimental Treatment1 Intervention

Find a Location

Logistics

Other reimbursement is provided

Other forms of reimbursement are provided for this trial.

Who is running the clinical trial?

The University of Texas Health Science Center, HoustonLead Sponsor
903 Previous Clinical Trials
320,953 Total Patients Enrolled
Sudhakar Selvaraj, MD,PhDPrincipal InvestigatorThe University of Texas Health Science Center, Houston
Jair Soares, MD, PhDPrincipal InvestigatorThe University of Texas Health Science Center, Houston

Media Library

LIFUP sonication (Ultrasound) Clinical Trial Eligibility Overview. Trial Name: NCT05194332 — N/A
LIFUP sonication (Ultrasound) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05194332 — N/A
Major Depressive Disorder Research Study Groups: LIFUP sonication to the amygdala
Major Depressive Disorder Clinical Trial 2023: LIFUP sonication Highlights & Side Effects. Trial Name: NCT05194332 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this trial open the door to individuals aged 55 or higher?

"The age range for eligibile participants is 18 to 75, though there are 106 trials open exclusively to people under the legal voting age and 590 studies that accept patients above retirement."

Answered by AI

For whom would this research be the most beneficial?

"To be selected for this clinical research, participants must have a diagnosis of psychosis and involutional depression. Those aged between 18 to 75 are eligible to apply with 24 total spots available in the study."

Answered by AI

Are there any open enrollment opportunities for this research endeavor?

"Unfortunately, per the information on clinicaltrials.gov this trial has stopped recruiting participants. It was initially posted on January 24th 2022 and final updates were completed by 1/3/2022. Even though enrollment for this study is now closed, there are 820 other trials that currently need patient volunteers to participate in their research."

Answered by AI

Who else is applying?

What state do they live in?
Texas
What site did they apply to?
The University of Texas Health Science Center at Houston
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
0
2

How responsive is this trial?

Average response time
  • < 2 Days
Typically responds via
Phone Call
Most responsive sites:
  1. The University of Texas Health Science Center at Houston: < 48 hours
Recent research and studies
clinicaltrials.govStudy
Transcranial Low Intensity Focused Ultrasound Neuromodulation as a Probe to Study Human Emotion and Cognitive Function
Jair Soares 2023. "Transcranial Low Intensity Focused Ultrasound Neuromodulation as a Probe to Study Human Emotion and Cognitive Function". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05194332.
~14 spots leftby Apr 2025
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