Proton Therapy for Brain Tumors
(HiPPI Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial studies how well a new form of radiation therapy works for patients with certain types of brain tumors. The goal is to see if this method can effectively control tumor growth while reducing side effects and making treatment more convenient.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is proton therapy generally safe for humans?
How is proton therapy for brain tumors different from other treatments?
Proton therapy for brain tumors is unique because it delivers radiation with a steep dose gradient, minimizing damage to surrounding healthy tissues compared to traditional photon therapy. This makes it particularly beneficial for tumors in complex areas or near sensitive tissues, reducing potential side effects.678910
What data supports the effectiveness of the treatment Proton Therapy for Brain Tumors?
Research shows that hypofractionated proton therapy, which is a type of radiation treatment, has been safely used and is effective for treating certain types of lung and prostate cancers. This suggests it might also be effective for brain tumors, as it allows for precise targeting of the tumor while minimizing damage to surrounding healthy tissue.811121314
Who Is on the Research Team?
Bree R. Eaton, MD
Principal Investigator
Emory University Hospital/Winship Cancer Institute
Are You a Good Fit for This Trial?
This trial is for individuals with benign brain tumors, including meningiomas, pituitary adenomas, and schwannomas. Participants must consent to treatment and be recommended for proton or photon radiation therapy. Pregnant women can't join, and women who can have children must test negative for pregnancy and agree to use effective birth control.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Patients undergo hypofractionated proton or photon radiation therapy daily, Monday-Friday over 17-20 fractions for 3.5-4 weeks
Follow-up
Participants are monitored for safety, effectiveness, and local tumor control after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Hypofractionated Radiation Therapy
- Photon Beam Radiation Therapy
- Proton Beam Radiation Therapy
Hypofractionated Radiation Therapy is already approved in United States, European Union, Canada for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
Emory University
Lead Sponsor
National Cancer Institute (NCI)
Collaborator