Macrodantin

Urinary Tract Infections, Cystitis
Treatment
2 FDA approvals
7 Active Studies for Macrodantin

What is Macrodantin

NitrofurantoinThe Generic name of this drug
Treatment SummaryNitrofurantoin is an antibiotic used to treat simple urinary tract infections. It works by blocking certain bacterial processes, which makes it harder for bacteria to become resistant to the medication. Nitrofurantoin is usually prescribed after sulfamethoxazole/trimethoprim fails to be effective. This drug was approved by the FDA in 1953.
Furadantinis the brand name
image of different drug pills on a surface
Macrodantin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Furadantin
Nitrofurantoin
1953
247

Approved as Treatment by the FDA

Nitrofurantoin, otherwise called Furadantin, is approved by the FDA for 2 uses such as Cystitis and Urinary Tract Infections .
Cystitis
Urinary Tract Infections

Effectiveness

How Macrodantin Affects PatientsNitrofurantoin works by disrupting how bacteria functions, which kills them. It quickly reaches the right levels in the urine and is also removed from the body quickly.
How Macrodantin works in the bodyNitrofurantoin is converted by bacteria into a form that changes how the cell creates energy and makes proteins, DNA, and RNA. This stops the bacteria from reproducing.

When to interrupt dosage

The quantity of Macrodantin is contingent upon the diagnosed affliction. The measure of dosage can be seen in the table below, in relation to the technique of delivery (e.g. Capsule or Capsule - Oral).
Condition
Dosage
Administration
Urinary Tract Infections
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 75.0 mg, 105.7 mg, 80.7 mg, 5.0 mg/mL
, Oral, Capsule, Capsule - Oral, Suspension, Suspension - Oral, Tablet, Tablet - Oral
Cystitis
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 75.0 mg, 105.7 mg, 80.7 mg, 5.0 mg/mL
, Oral, Capsule, Capsule - Oral, Suspension, Suspension - Oral, Tablet, Tablet - Oral

Warnings

Macrodantin has nine prohibitive contraindications, thus it should not be utilized for any of the conditions stated in the table below.Macrodantin Contraindications
Condition
Risk Level
Notes
Anuria
Do Not Combine
Pulse Frequency
Do Not Combine
imminent onset of labor
Do Not Combine
Term Birth (Pregnancy)
Do Not Combine
Jaundice, Obstructive
Do Not Combine
Liver Dysfunction
Do Not Combine
Oliguria
Do Not Combine
Parturition
Do Not Combine
Labour
Do Not Combine
There are 20 known major drug interactions with Macrodantin.
Common Macrodantin Drug Interactions
Drug Name
Risk Level
Description
Cinoxacin
Major
The therapeutic efficacy of Cinoxacin can be decreased when used in combination with Nitrofurantoin.
Ciprofloxacin
Major
The therapeutic efficacy of Ciprofloxacin can be decreased when used in combination with Nitrofurantoin.
Delafloxacin
Major
The therapeutic efficacy of Delafloxacin can be decreased when used in combination with Nitrofurantoin.
Difloxacin
Major
The therapeutic efficacy of Difloxacin can be decreased when used in combination with Nitrofurantoin.
Enoxacin
Major
The therapeutic efficacy of Enoxacin can be decreased when used in combination with Nitrofurantoin.
Macrodantin Toxicity & Overdose RiskOverdosing on nitrofurantoin may cause vomiting. If vomiting has not already occurred, it can be induced and fluids should be increased to promote urination. In extreme cases, dialysis can be used to remove the drug from circulation.
image of a doctor in a lab doing drug, clinical research

Macrodantin Novel Uses: Which Conditions Have a Clinical Trial Featuring Macrodantin?

At present, 10 investigations are investigating the potential of Macrodantin to treat Urinary Tract Infections.
Condition
Clinical Trials
Trial Phases
Cystitis
0 Actively Recruiting
Urinary Tract Infections
7 Actively Recruiting
Not Applicable, Phase 4

Macrodantin Reviews: What are patients saying about Macrodantin?

5Patient Review
6/14/2013
Macrodantin for Urinary Tract Infection due to E. Coli Bacteria
This medication has been really effective in treating my chronic UTI. The only downside is that it leaves a bad taste in my mouth.
5Patient Review
11/7/2013
Macrodantin for Bacterial Urinary Tract Infection
This medication is excellent for treating bladder infections. I had a reoccurring infection 3 times in four months, and this completely cleared it up.
5Patient Review
8/25/2014
Macrodantin for Urinary Tract Infection Prevention
I used to suffer from UTIs all the time when I was younger, and nothing seemed to help. Finally, a doctor put me on Macrodantin and it's been 30 years without a single infection. It works great for me, but I do get nauseous when I take the generic version.
4.7Patient Review
11/29/2013
Macrodantin for Urinary Tract Infection Prevention
I've had bladder infections for thirty years and this is the first treatment that's given me any relief. I take 100mg every other day and have been cystitis-free for over a year now.
4.3Patient Review
4/17/2013
Macrodantin for Urinary Tract Infection caused by Klebsiella Bacteria
3Patient Review
7/22/2014
Macrodantin for Bacterial Urinary Tract Infection
The medication did work in that it got rid of my UTI, but the nausea was unbearable. I tried following the directions and taking it with food, but it made no difference.
1.7Patient Review
3/25/2014
Macrodantin for Bacterial Urinary Tract Infection
I frequently get UTIs, but this is the first time I've experienced such severe side effects. Woke up feeling nauseous and have been in bed all day with terrible flu-like symptoms. Pains in my neck, kidneys and legs. Will not be taking this medication again.
1Patient Review
5/2/2014
Macrodantin for Bacterial Urinary Tract Infection
I was so sick while taking this drug that I couldn't even leave my bed. Stomach pain, nausea, headache, and a terrible cough made me feel like I was being poisoned.
1Patient Review
4/14/2014
Macrodantin for Bacterial Urinary Tract Infection
My wife started taking Macrodantin for urinary tract infections. After being on the drug for two years, she turned yellow from liver failure due to "Macrodantin Toxicity." She needed a liver transplant to save her life. If you look at Macrodantin in the PDR, it lists necrosis of the liver as a possible side effect. This is a very dangerous drug!!!
1Patient Review
12/9/2013
Macrodantin for Bacterial Urinary Tract Infection
I was prescribed Macrodantin for a urinary tract infection many years ago. The very first pill made me so nauseous that I threw up and felt weak and ill overall. I stopped taking it immediately and contacted the prescribing physician. I would never take it again.
1Patient Review
11/15/2016
Macrodantin for Bacterial Urinary Tract Infection
I was given this drug when I was 34 weeks pregnant. Two days later, I had a stillborn. He died while I was on the medicine. No one told me not to take it.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about macrodantin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How long do you take Macrodantin for UTI?

"How long you will need to take nitrofurantoin will depend on why you are taking it. If you are taking it to treat a urinary tract infection, you will usually need to take it for 3 to 7 days. If you are taking it to prevent urinary tract infections from occurring again, you may need to take it for several months."

Answered by AI

What kind of antibiotic is Macrodantin?

"Nitrofurantoin is an antibiotic used to treat urinary tract infections. It works by killing the bacteria that cause the infection."

Answered by AI

What is Macrodantin antibiotic used for?

"This antibiotic is used to treat urinary tract infections, or to prevent them if you are susceptible to them. It works by stopping the growth of bacteria, though it will not work on viruses, such as the common cold or the flu. Overusing antibiotics can lead to antibiotic resistance, so it is important to only use them when necessary."

Answered by AI

What infections does Macrodantin treat?

"The following are various types of urinary tract infections and the bacteria that cause them:

-A bladder infection caused by Enterobacter

-A urinary tract infection prevention

-An infection of the urinary tract caused by Enterococcus

-A urinary tract infection due to E. ...

-A urinary tract infection caused by Klebsiella bacteria

-A urinary tract infection caused by Staphylococcus aureus"

Answered by AI

Clinical Trials for Macrodantin

Image of Baylor College of Medicine in Houston, United States.

Educational Tool for Urinary Tract Infections

18+
All Sexes
Houston, TX
Urine culture is the most common microbiological test in the outpatient setting in the United States. Unfortunately, contamination during collection is prevalent and undermines test accuracy, leading to incorrect diagnosis, unnecessary treatment, wasted laboratory resources, and inflated costs. Unnecessary antibiotic treatment increases the risk of developing antimicrobial resistance, one of the most serious threats to patients and public health. The goal of this clinical trial is to test whether a bilingual (English and Spanish) educational intervention, an animated video and pictorial flyer, can reduce urine culture contamination and associated inappropriate antibiotic use in adult patients visiting safety-net primary care clinics. The main questions it aims to answer are: 1. Does providing patients with a bilingual educational intervention reduce urine culture contamination rates? 2. Does the intervention lead to fewer unnecessary urinary antibiotic prescriptions? 3. Does providing patients with a bilingual educational intervention reduce contaminated urinalyses? Researchers will compare patients randomized to receive the educational intervention (video and flyer) to those receiving usual care to see if the intervention improves urine collection accuracy and reduces inappropriate antibiotic use. Participants will watch a short, animated video with step-by-step instructions for proper midstream clean-catch urine (MSCC) collection, receive a pictorial flyer (with stills from the video) reinforcing the instructions, and provide a urine sample for culture. For our hypothesis, patients who receive the educational intervention will have: lower urine culture contamination rates (primary outcome), fewer urinary antibiotic prescriptions (secondary outcome), and fewer contaminated urinalyses (secondary outcome). The objectives are to (1) develop educational tools: Create an animated video and pictorial flyer with step-by-step urine collection instructions for women and men, developed through an iterative, stakeholder-engaged process, (2) assess acceptability: Use mixed methods (quantitative surveys and qualitative interviews) to evaluate and refine the tools for usability and cultural/linguistic appropriateness, and (3) test effectiveness: Conduct a randomized controlled trial to assess the intervention's impact on urine contamination rates, antibiotic prescribing, and patient satisfaction.
Waitlist Available
Has No Placebo
Baylor College of MedicineLarissa Grigoryan, MD, PhD
Image of UPMC Magee-Womens Hospital in Pittsburgh, United States.

Catheterization Methods for Postpartum Urinary Problems

18+
All Sexes
Pittsburgh, PA
At least ten percent of patients have postpartum urinary retention or difficulty urinating after birth, which can cause incontinence and other urinary problems long-term. After getting an epidural placed, patients should be numb in their pelvic region. This numbness makes it difficult to feel the need to urinate, so patients need a urinary catheter placed to empty the bladder. Some patients have one catheter placed throughout their labor and others have a catheter placed to empty the bladder then removed every few hours. The investigators are studying whether placing a catheter once or catheterizing multiple times affects the rate of postpartum urinary problems and infection.
Waitlist Available
Has No Placebo
UPMC Magee-Womens HospitalAnna Binstock, MD
Image of University of California, San Francisco in San Francisco, United States.

Trimethoprim-Sulfamethoxazole for Urinary Tract Infections

13 - 29
All Sexes
San Francisco, CA
The goal of this clinical trial is to learn if a common antibiotic called trimethoprim-sulfamethoxazole (TMP-SMX) can help prevent urinary tract infections (UTIs) in children and young adults who recently had a kidney transplant. Most people take TMP-SMX for about 6 months after getting a kidney transplant. In this study, researchers want to see what happens if people keep taking it for 6 more months. The main questions this study is asking are: * Does TMP-SMX lower the number of UTIs in the first year after transplant? * What side effects or problems do participants have while taking TMP-SMX? Researchers will compare TMP-SMX to a placebo (a look-alike pill that does not contain any medication) to see if TMP-SMX works to prevent UTIs. Participants will: * Take either TMP-SMX or a placebo pill by mouth every day for 6 months * Have three visits to touch base with the study team about any issues * Complete short monthly online surveys about any symptoms or side effects * Share blood and urine test results from their regular transplant clinic visits
Phase 4
Waitlist Available
University of California, San FranciscoAlexandra Bicki, MD
Have you considered Macrodantin clinical trials? We made a collection of clinical trials featuring Macrodantin, we think they might fit your search criteria.Go to Trials
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Methenamine for Urinary Tract Infection

18 - 100
Female
Morristown, NJ
Stress urinary incontinence (SUI) affects at least 40% of women in the United States. Synthetic polypropylene mid-urethral slings (MUS) are the gold standard treatment for SUI. Post-operative urinary tract infections (UTI) are one of the most common complications after MUS placement. Some studies have demonstrated that MUS placement can increase the risk of UTI up to 21-34%. Post-operative UTI can lead to significant healthcare and patient burden. This additional burden further contributes to an estimated annual cost of $1.6 billion for UTI management in the United States. With increased antibiotic usage, there is simultaneous increase in bacterial resistance leading to treatment refractory UTI. The investigators prescribe post-operative antibiotics prophylactically for 3 days after MUS placement with or without concurrent pelvic reconstructive surgery based on prior literature recommending post-operative prophylaxis. There is a greater emphasis on limiting antibiotic use given the trend of development of bacterial resistance. There are studies supporting alternatives such as methenamine for recurrent UTI prophylaxis treatment, but there are limited studies evaluating methenamine for UTI prophylaxis after MUS.
Recruiting
Has No Placebo
Atlantic Health
Image of Vriginia Mason Medical Center in Seattle, United States.

Antibiotic Usage for Overactive Bladder

18+
All Sexes
Seattle, WA
Intradetrusor injection of onabotulinumtoxinA, which is performed through a cystoscopic procedure, has been demonstrated to be efficacious in the treatment of both neurogenic and non-neurogenic overactive bladder (OAB), and is FDA approved as a treatment for overactive bladder. Intradetrusor of onabotulinumtoxinA is currently standard of care of patients with OAB who have persistent OAB symptoms despite behavioral therapies and oral medication treatments for OAB. As one of the main adverse events associated with intradetrusor injection of onabotulinumtoxinA is UTI, and published guidelines for cystoscopic procedures with manipulation recommend the use of prophylactic antibiotics, a single dose of prophylactic antibiotic is administered prior to this procedure. However, these recommendations are primarily based on data from randomized controlled trials (RCTs) involving antimicrobial prophylaxis during transurethral resection of the prostate. A previously published prospective study demonstrated that the rate of post-procedural UTI did not differ amongst patients with neurogenic bladder who did not receive prophylactic antibiotics and were asymptomatic for UTI, regardless of whether they had sterile urine cultures or asymptomatic bacteriuria, suggesting that patients who are not symptomatic for UTI may not require antibiotic prophylaxis prior to intradetrusor onabotulinumtoxinA injection. Studies have reported that up to 50% of antibiotic usage is inappropriate, leading to unnecessary exposure of patients to potential complications of antibiotic therapy, including Clostridium difficile infection which can cause recurrent diarrhea that may progress to sepsis and death, increasing antibiotic resistances, as well as dermal/allergic and gastro-intestinal manifestations. Therefore, in an effort to optimize antibiotic use, the investigators propose a prospective, randomized study to formally evaluate the differences in UTI frequency in subjects who have a negative urinalysis and are not symptomatic for UTI and receive prophylactic antibiotics at the time of intradetrusor onabotulinumtoxinA injection compared to those who do not receive prophylactic antibiotics at the time of injection. The proposed study seeks to evaluate the current practice standard of antibiotic prophylaxis prior to intradetrusor onabotulinumtoxin injection.
Recruiting
Has No Placebo
Vriginia Mason Medical Center (+1 Sites)Justina Tam, MD
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