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What is Macrodantin
NitrofurantoinThe Generic name of this drug
Treatment SummaryNitrofurantoin is an antibiotic used to treat simple urinary tract infections. It works by blocking certain bacterial processes, which makes it harder for bacteria to become resistant to the medication. Nitrofurantoin is usually prescribed after sulfamethoxazole/trimethoprim fails to be effective. This drug was approved by the FDA in 1953.
Furadantinis the brand name
Macrodantin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Furadantin
Nitrofurantoin
1953
247
Approved as Treatment by the FDA
Nitrofurantoin, otherwise called Furadantin, is approved by the FDA for 2 uses such as Urinary Tract Infection and Cystitis .Urinary Tract Infection
Cystitis
Effectiveness
How Macrodantin Affects PatientsNitrofurantoin works by disrupting how bacteria functions, which kills them. It quickly reaches the right levels in the urine and is also removed from the body quickly.
How Macrodantin works in the bodyNitrofurantoin is converted by bacteria into a form that changes how the cell creates energy and makes proteins, DNA, and RNA. This stops the bacteria from reproducing.
When to interrupt dosage
The quantity of Macrodantin is contingent upon the diagnosed affliction. The measure of dosage can be seen in the table below, in relation to the technique of delivery (e.g. Capsule or Capsule - Oral).Condition
Dosage
Administration
Cystitis
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 75.0 mg, 105.7 mg, 80.7 mg, 5.0 mg/mL
, Oral, Capsule, Capsule - Oral, Suspension, Suspension - Oral, Tablet, Tablet - Oral
Urinary Tract Infection
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 75.0 mg, 105.7 mg, 80.7 mg, 5.0 mg/mL
, Oral, Capsule, Capsule - Oral, Suspension, Suspension - Oral, Tablet, Tablet - Oral
Warnings
Macrodantin has nine prohibitive contraindications, thus it should not be utilized for any of the conditions stated in the table below.Macrodantin ContraindicationsCondition
Risk Level
Notes
Anuria
Do Not Combine
Pulse Frequency
Do Not Combine
imminent onset of labor
Do Not Combine
Term Birth (Pregnancy)
Do Not Combine
Jaundice, Obstructive
Do Not Combine
Liver Dysfunction
Do Not Combine
Oliguria
Do Not Combine
Parturition
Do Not Combine
Labour
Do Not Combine
Common Macrodantin Drug Interactions
Drug Name
Risk Level
Description
Cinoxacin
Major
The therapeutic efficacy of Cinoxacin can be decreased when used in combination with Nitrofurantoin.
Ciprofloxacin
Major
The therapeutic efficacy of Ciprofloxacin can be decreased when used in combination with Nitrofurantoin.
Delafloxacin
Major
The therapeutic efficacy of Delafloxacin can be decreased when used in combination with Nitrofurantoin.
Difloxacin
Major
The therapeutic efficacy of Difloxacin can be decreased when used in combination with Nitrofurantoin.
Enoxacin
Major
The therapeutic efficacy of Enoxacin can be decreased when used in combination with Nitrofurantoin.
Macrodantin Toxicity & Overdose RiskOverdosing on nitrofurantoin may cause vomiting. If vomiting has not already occurred, it can be induced and fluids should be increased to promote urination. In extreme cases, dialysis can be used to remove the drug from circulation.
Macrodantin Novel Uses: Which Conditions Have a Clinical Trial Featuring Macrodantin?
At present, 10 investigations are investigating the potential of Macrodantin to treat Urinary Tract Infections.Condition
Clinical Trials
Trial Phases
Urinary Tract Infection
8 Actively Recruiting
Not Applicable, Phase 4, Phase 3
Cystitis
0 Actively Recruiting
Macrodantin Reviews: What are patients saying about Macrodantin?
5Patient Review
6/14/2013 This medication has been really effective in treating my chronic UTI. The only downside is that it leaves a bad taste in my mouth.
5Patient Review
11/7/2013 This medication is excellent for treating bladder infections. I had a reoccurring infection 3 times in four months, and this completely cleared it up.
5Patient Review
8/25/2014 I used to suffer from UTIs all the time when I was younger, and nothing seemed to help. Finally, a doctor put me on Macrodantin and it's been 30 years without a single infection. It works great for me, but I do get nauseous when I take the generic version.
4.7Patient Review
11/29/2013 I've had bladder infections for thirty years and this is the first treatment that's given me any relief. I take 100mg every other day and have been cystitis-free for over a year now.
4.3Patient Review
4/17/20133Patient Review
7/22/2014 The medication did work in that it got rid of my UTI, but the nausea was unbearable. I tried following the directions and taking it with food, but it made no difference.
1.7Patient Review
3/25/2014 I frequently get UTIs, but this is the first time I've experienced such severe side effects. Woke up feeling nauseous and have been in bed all day with terrible flu-like symptoms. Pains in my neck, kidneys and legs. Will not be taking this medication again.
1Patient Review
5/2/2014 I was so sick while taking this drug that I couldn't even leave my bed. Stomach pain, nausea, headache, and a terrible cough made me feel like I was being poisoned.
1Patient Review
4/14/2014 My wife started taking Macrodantin for urinary tract infections. After being on the drug for two years, she turned yellow from liver failure due to "Macrodantin Toxicity." She needed a liver transplant to save her life. If you look at Macrodantin in the PDR, it lists necrosis of the liver as a possible side effect. This is a very dangerous drug!!!
1Patient Review
12/9/2013 I was prescribed Macrodantin for a urinary tract infection many years ago. The very first pill made me so nauseous that I threw up and felt weak and ill overall. I stopped taking it immediately and contacted the prescribing physician. I would never take it again.
1Patient Review
11/15/2016 I was given this drug when I was 34 weeks pregnant. Two days later, I had a stillborn. He died while I was on the medicine. No one told me not to take it.
Patient Q&A Section about macrodantin
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How long do you take Macrodantin for UTI?
"How long you will need to take nitrofurantoin will depend on why you are taking it. If you are taking it to treat a urinary tract infection, you will usually need to take it for 3 to 7 days. If you are taking it to prevent urinary tract infections from occurring again, you may need to take it for several months."
Answered by AI
What kind of antibiotic is Macrodantin?
"Nitrofurantoin is an antibiotic used to treat urinary tract infections. It works by killing the bacteria that cause the infection."
Answered by AI
What is Macrodantin antibiotic used for?
"This antibiotic is used to treat urinary tract infections, or to prevent them if you are susceptible to them. It works by stopping the growth of bacteria, though it will not work on viruses, such as the common cold or the flu. Overusing antibiotics can lead to antibiotic resistance, so it is important to only use them when necessary."
Answered by AI
What infections does Macrodantin treat?
"The following are various types of urinary tract infections and the bacteria that cause them:
-A bladder infection caused by Enterobacter
-A urinary tract infection prevention
-An infection of the urinary tract caused by Enterococcus
-A urinary tract infection due to E. ...
-A urinary tract infection caused by Klebsiella bacteria
-A urinary tract infection caused by Staphylococcus aureus"
Answered by AI