Prophylactic Antibiotics for Urinary Incontinence
What You Need to Know Before You Apply
What is the purpose of this trial?
The primary aim of this study is to assess the utility of prophylactic oral antibiotics at time of Bulkamid transurethral bulking to reduce the incidence of urinary tract infection (UTI) in the immediate postoperative period. The secondary aims of the study include assessing UTI rates and success rates if patients require temporary indwelling catheter versus intermittent self-catheterization (ISC).
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but if you are taking daily antibiotics, you cannot participate. Also, if you've had recent antibiotic treatment within a week of the procedure, you may not be eligible.
Is it safe to use prophylactic antibiotics like Bactrim and Macrobid for urinary incontinence?
Studies show that antibiotics like Bactrim and Macrobid are generally safe for preventing infections, but they can cause side effects like skin rashes and stomach issues. In one study, 6% of patients experienced skin problems, and some had stomach disturbances, but these side effects were not common enough to be statistically significant.12345
How does the drug Bactrim differ from other treatments for urinary incontinence?
Bactrim, a combination of trimethoprim and sulfamethoxazole, is used as a prophylactic antibiotic to prevent infections, which is different from other treatments for urinary incontinence that may not focus on infection prevention. This approach is unique because it targets the prevention of urinary tract infections, which can be a complication associated with urinary incontinence, especially after surgery.12467
Is there evidence that the drug Bactrim is effective for preventing urinary tract infections after gynecological surgery?
Who Is on the Research Team?
Susanne Taege, MD
Principal Investigator
Ohio State University
Are You a Good Fit for This Trial?
This trial is for individuals planning to undergo Bulkamid treatment for stress urinary incontinence or mixed urinary incontinence at The Ohio State University. Participants must not have recurrent UTIs, be on daily antibiotics, pregnant, have significant pelvic organ prolapse or immunosuppression, and should not have taken recent antibiotics.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Pre-operative
Participants receive either a placebo pill or oral antibiotic in the pre-operative holding area prior to their procedure
Immediate Post-operative
Participants are monitored for post-operative urinary tract infections (UTI) and other immediate effects
Follow-up
Participants complete surveys to assess improvement in stress urinary incontinence and patient satisfaction
What Are the Treatments Tested in This Trial?
Interventions
- Bactrim
- Macrobid
Find a Clinic Near You
Who Is Running the Clinical Trial?
Ohio State University
Lead Sponsor