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What is Trilafon
PerphenazineThe Generic name of this drug
Treatment SummaryA medication used to treat mental health disorders, similar to the effects of chlorpromazine.
Perphenazineis the brand name
Trilafon Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Perphenazine
Perphenazine
1987
153
Approved as Treatment by the FDA
Perphenazine, also known as Perphenazine, is approved by the FDA for 11 uses like moderate Agitation and severe agitation .moderate Agitation
Used to treat moderate Agitation in combination with Amitriptyline
severe agitation
Used to treat severe agitation in combination with Amitriptyline
Nausea
Depression
Used to treat Depression in combination with Amitriptyline
Generalized Anxiety Disorder
Used to treat Anxiety in combination with Amitriptyline
Schizophrenia
Helps manage Schizophrenia
Chronic Physical Illness
Used to treat Chronic Physical Illness in combination with Amitriptyline
moderate Anxiety
Used to treat moderate Anxiety in combination with Amitriptyline
Anxiety
Used to treat severe Anxiety in combination with Amitriptyline
Mental Depression
Used to treat moderate Depressed mood in combination with Amitriptyline
Mental Depression
Used to treat severe Depressed mood in combination with Amitriptyline
Effectiveness
How Trilafon Affects PatientsPerphenazine is a powerful medication used to treat psychiatric disorders. It belongs to a class of drugs called phenothiazines, which block the chemical dopamine in the brain. Perphenazine is 10-15 times stronger than other phenothiazine drugs and is just as effective as haloperidol in treating symptoms, but may cause similar early and late side effects.
How Trilafon works in the bodyPerphenazine works by blocking the activity of dopamine receptors, which are responsible for sending signals to the vomiting center in the brain. It also binds to alpha-adrenergic receptors and stops them from sending messages that could lead to nausea and vomiting.
When to interrupt dosage
The prescribed measure of Trilafon is contingent upon the diagnosed ailment, including Generalized Anxiety Disorder, moderate Agitation and Depression. The amount of dosage is contingent upon the administration technique (e.g. Syrup - Oral or Tablet, sugar coated - Oral) outlined in the accompanying table.Condition
Dosage
Administration
moderate Agitation
, 2.0 mg, 4.0 mg, 8.0 mg, 16.0 mg, 3.0 mg, 5.0 mg/mL, 2.0 mg/mL, 3.2 mg/mL, 16.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral
Mental Depression
, 2.0 mg, 4.0 mg, 8.0 mg, 16.0 mg, 3.0 mg, 5.0 mg/mL, 2.0 mg/mL, 3.2 mg/mL, 16.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral
severe agitation
, 2.0 mg, 4.0 mg, 8.0 mg, 16.0 mg, 3.0 mg, 5.0 mg/mL, 2.0 mg/mL, 3.2 mg/mL, 16.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral
Anxiety
, 2.0 mg, 4.0 mg, 8.0 mg, 16.0 mg, 3.0 mg, 5.0 mg/mL, 2.0 mg/mL, 3.2 mg/mL, 16.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral
Nausea
, 2.0 mg, 4.0 mg, 8.0 mg, 16.0 mg, 3.0 mg, 5.0 mg/mL, 2.0 mg/mL, 3.2 mg/mL, 16.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral
Generalized Anxiety Disorder
, 2.0 mg, 4.0 mg, 8.0 mg, 16.0 mg, 3.0 mg, 5.0 mg/mL, 2.0 mg/mL, 3.2 mg/mL, 16.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral
Depression
, 2.0 mg, 4.0 mg, 8.0 mg, 16.0 mg, 3.0 mg, 5.0 mg/mL, 2.0 mg/mL, 3.2 mg/mL, 16.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral
Mental Depression
, 2.0 mg, 4.0 mg, 8.0 mg, 16.0 mg, 3.0 mg, 5.0 mg/mL, 2.0 mg/mL, 3.2 mg/mL, 16.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral
Schizophrenia
, 2.0 mg, 4.0 mg, 8.0 mg, 16.0 mg, 3.0 mg, 5.0 mg/mL, 2.0 mg/mL, 3.2 mg/mL, 16.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral
Chronic Physical Illness
, 2.0 mg, 4.0 mg, 8.0 mg, 16.0 mg, 3.0 mg, 5.0 mg/mL, 2.0 mg/mL, 3.2 mg/mL, 16.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral
moderate Anxiety
, 2.0 mg, 4.0 mg, 8.0 mg, 16.0 mg, 3.0 mg, 5.0 mg/mL, 2.0 mg/mL, 3.2 mg/mL, 16.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral
Warnings
Trilafon ContraindicationsCondition
Risk Level
Notes
large dose of CNS depressants
Do Not Combine
Brain Injuries
Do Not Combine
Liver Damage
Do Not Combine
Comatose
Do Not Combine
Disease
Do Not Combine
greatly obtunded patients
Do Not Combine
Bone Marrow
Do Not Combine
Common Trilafon Drug Interactions
Drug Name
Risk Level
Description
Amisulpride
Major
Perphenazine may increase the antipsychotic activities of Amisulpride.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Perphenazine.
Azelastine
Major
Perphenazine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Dacomitinib
Major
The metabolism of Dacomitinib can be decreased when combined with Perphenazine.
Deutetrabenazine
Major
The risk or severity of adverse effects can be increased when Perphenazine is combined with Deutetrabenazine.
Trilafon Toxicity & Overdose RiskSigns of an overdose of this drug include confusion and unconsciousness, and children may have seizures. It may take up to 48 hours for symptoms to become noticeable. Tests in rats and mice show that the lowest toxic dose is 318 mg/kg and 64 mg/kg, respectively.
Trilafon Novel Uses: Which Conditions Have a Clinical Trial Featuring Trilafon?
At present, 985 active clinical trials are investigating the potential of Trilafon to alleviate moderate Agitation, Anxiety and Nausea.Condition
Clinical Trials
Trial Phases
moderate Agitation
0 Actively Recruiting
Generalized Anxiety Disorder
243 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Early Phase 1, Phase 4
Chronic Physical Illness
0 Actively Recruiting
Schizophrenia
174 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 4, Phase 1
Anxiety
0 Actively Recruiting
severe agitation
0 Actively Recruiting
Depression
698 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 1, Early Phase 1, Phase 4
Mental Depression
0 Actively Recruiting
moderate Anxiety
0 Actively Recruiting
Nausea
0 Actively Recruiting
Mental Depression
0 Actively Recruiting
Trilafon Reviews: What are patients saying about Trilafon?
5Patient Review
9/25/2009 TARDIVE DYSKINESIA
5Patient Review
3/24/2010 I've tried a lot of different antipsychotics, and this is the first one that's both effective and doesn't have too many side effects.
5Patient Review
11/26/2010 I've tried other medications in the same class as Trilafon, and this one is by far the most effective with the least amount of side effects.
4.7Patient Review
5/7/2010 I have bipolar disorder, ADHD, and severe anxiety disorder. I've been on Trilafon for a little while now and it's really helped to stabilize my moods. Much better than any other medication I've tried in the past.
4.7Patient Review
4/10/2010 I initially forgot to take this medication, but I was really pleased with how it curbed my appetite. I didn't feel the need to overeat anymore.
4Patient Review
7/14/2010 I felt more focused and energetic, with fewer racing thoughts.
4Patient Review
6/2/20093.7Patient Review
5/14/2013 This medication was highly effective at removing my positive symptoms of schizophrenia. However, I developed abnormal mouth and tongue movements as a result. These movements have continued even after going off the medication, which has been since January. Therefore, I would not recommend this drug to anyone.
2.3Patient Review
9/29/2012 I was prescribed this medication after being misdiagnosed while in foster care. Even though it's been three years since I stopped taking the medicine, I continue to suffer from a variety of side effects, including sun sensitivity, irregular periods, an irregular heartbeat, sexual problems and eye twitches.
1Patient Review
2/15/2012 This treatment made me feel really out of it and not in a good way.
Patient Q&A Section about trilafon
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What does perphenazine do to your brain?
"Perphenazine is a type of medication known as a conventional antipsychotic. It works by reducing abnormal excitement in the brain."
Answered by AI
How long does it take for Trilafon to work?
"It may take as much as 4-6 weeks of regular use to see the full benefit of the medication, even though you may notice some effects soon after starting."
Answered by AI
Is Trilafon still available?
"The drug Trilafon is no longer being manufactured in the United States, but similar drugs may still be available. Trilafon was an antipsychotic drug used to treat schizophrenia. It belonged to a class of drugs called phenothiazines."
Answered by AI
What is Trilafon used for?
"Aripiprazole works by helping to restore the balance of certain natural substances (neurotransmitters) in the brain.
Aripiprazole is a medication used to treat certain mental disorders such as schizophrenia and bipolar disorder. This medicine helps the patient to think more clearly and take part in everyday life. It can reduce aggressive behavior and the desire to hurt oneself or others. Aripiprazole works by restoring the balance of certain neurotransmitters in the brain."
Answered by AI