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What is Spironolactone And Hydrochlorothiazide
SpironolactoneThe Generic name of this drug
Treatment SummaryHydrochlorothiazide is a type of medication used to treat high blood pressure and swelling caused by excess fluid. It is the most commonly prescribed diuretic but is being used less in favor of other medications, such as angiotensin converting enzyme inhibitors. Combination medications are available that contain both hydrochlorothiazide and angiotensin converting enzyme inhibitors or angiotensin II receptor blockers. Hydrochlorothiazide was approved by the FDA in 1959.
Spironolactoneis the brand name
Spironolactone And Hydrochlorothiazide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Spironolactone
Spironolactone
1960
288
Approved as Treatment by the FDA
Spironolactone, also known as Spironolactone, is approved by the FDA for 11 uses such as Hypesthesia and Hypokalemia .Hypesthesia
Helps manage chronic heart failure with reduced ejection fraction (NYHA Class III)
Hypokalemia
Swollen feet or ankles
Helps manage Edema
Hyperaldosteronism
Helps manage idiopathic hyperaldosteronism
Ascites
Helps manage Ascites
Hypesthesia
Helps manage chronic heart failure with reduced ejection fraction (NYHA Class IV)
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Nephrotic Syndrome
Helps manage Nephrotic Syndrome
Congestive Heart Failure
Helps manage Congestive Heart Failure (CHF)
Primary Hyperaldosteronism
Helps manage Primary Hyperaldosteronism
Cirrhosis
Helps manage Cirrhosis of the Liver
Effectiveness
How Spironolactone And Hydrochlorothiazide Affects PatientsHydrochlorothiazide helps the body get rid of extra water by blocking the kidneys from absorbing too much salt and water. Everyone's individual dose can range from 25-100mg. It is important to be cautious when taking this drug if you have any issues with your kidneys or liver.
How Spironolactone And Hydrochlorothiazide works in the bodyHydrochlorothiazide works by blocking a protein in the kidneys called SLC12A3, which helps the body to reabsorb sodium and chloride. This protein also helps to reabsorb water. When hydrochlorothiazide blocks this protein, it reduces the amount of sodium and chloride that is reabsorbed, and also reduces the amount of water being reabsorbed. This leads to increased urination and helps to lower blood pressure.
When to interrupt dosage
The measure of Spironolactone And Hydrochlorothiazide is subject to the diagnosed condition, including Antepartum magnesium sulfate counteractive measure, blood pressure inadequately controlled with monotherapy and antihypertensives. The dosage varies as indicated by the technique of delivery (e.g. Tablet, coated - Oral or Oral) featured in the table underneath.Condition
Dosage
Administration
Primary Hyperaldosteronism
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Hyperaldosteronism
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Secondary hyperaldosteronism
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Hypertensive disease
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Hypesthesia
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Hirsutism
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
nonresponsive to antihypertensive monotherapy
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Hypesthesia
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Cirrhosis
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Nephrotic Syndrome
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Edema
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Acne
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Congestive Heart Failure
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Swollen feet or ankles
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Ascites
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Hypokalemia
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
inadequate response to other therapeutic measures
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Warnings
Spironolactone And Hydrochlorothiazide has two contraindications, so it should not be consumed when dealing with any of the conditions shown in the accompanying table.Spironolactone And Hydrochlorothiazide ContraindicationsCondition
Risk Level
Notes
significant impairment of renal excretory function
Do Not Combine
Anuria
Do Not Combine
Renal Insufficiency, Acute
Do Not Combine
Hyperkalemia
Do Not Combine
Pulse Frequency
Do Not Combine
Addison's Disease
Do Not Combine
Common Spironolactone And Hydrochlorothiazide Drug Interactions
Drug Name
Risk Level
Description
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Spironolactone.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Spironolactone.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Spironolactone.
Cyclosporine
Major
The risk or severity of hyperkalemia can be increased when Spironolactone is combined with Cyclosporine.
Dabrafenib
Major
The metabolism of Dabrafenib can be decreased when combined with Spironolactone.
Spironolactone And Hydrochlorothiazide Toxicity & Overdose RiskThe lowest toxic dose of hydrochlorothiazide in mice and rats has been found to be greater than 10g/kg. Those who overdose may experience low potassium, chloride, and sodium levels. Treatment for an overdose includes fluids and electrolytes, as well as vasopressors to treat low blood pressure, and oxygen if breathing is impaired.
Spironolactone And Hydrochlorothiazide Novel Uses: Which Conditions Have a Clinical Trial Featuring Spironolactone And Hydrochlorothiazide?
158 active studies are examining the potential of Spironolactone And Hydrochlorothiazide in providing relief from Cirrhosis, Edema and Congestive Heart Failure.Condition
Clinical Trials
Trial Phases
Hypesthesia
8 Actively Recruiting
Not Applicable, Phase 1
Acne
6 Actively Recruiting
Phase 4, Early Phase 1, Not Applicable, Phase 1, Phase 2
Hypokalemia
0 Actively Recruiting
Hyperaldosteronism
0 Actively Recruiting
Edema
0 Actively Recruiting
Swollen feet or ankles
40 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 3, Phase 4
nonresponsive to antihypertensive monotherapy
0 Actively Recruiting
Primary Hyperaldosteronism
0 Actively Recruiting
Ascites
10 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2
inadequate response to other therapeutic measures
0 Actively Recruiting
Nephrotic Syndrome
11 Actively Recruiting
Phase 2, Not Applicable, Phase 3
Secondary hyperaldosteronism
0 Actively Recruiting
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Cirrhosis
50 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Phase 3, Early Phase 1
Hypesthesia
5 Actively Recruiting
Not Applicable, Early Phase 1, Phase 1
Congestive Heart Failure
22 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Hirsutism
0 Actively Recruiting
Spironolactone And Hydrochlorothiazide Reviews: What are patients saying about Spironolactone And Hydrochlorothiazide?
5Patient Review
8/24/2009 I had no idea that this medication didn't include a diuretic. I'm glad I found this website so that I could learn more about what I'm taking and why.
5Patient Review
11/7/20075Patient Review
1/3/2013 This medication has helped me a lot with my nocturnal leg cramps.
4.7Patient Review
12/23/2014 I accidentally took two doses today. What should I do?
4.3Patient Review
2/6/2017 At first, I had to go to the restroom more often after taking this pill at night. However, about a month and a half later, I started feeling dizzy during my workouts. Once I reduced the intensity of my workout regime, the lightheadedness went away.
4Patient Review
5/12/2009 This medication caused my potassium levels to drop drastically, to the point where I am now exhausted and weak. I've also lost a lot of weight, which is alarming considering I only weigh 124lbs on my heavy days.
4Patient Review
8/1/2018 I found this drug to be effective for me.
3.7Patient Review
2/27/2008 Spirono/HCTZ has been a godsend for me. Without it, my body retains so much water that my skin stretches tight and looks like it might split.
3Patient Review
2/21/2011 The main side effect I've noticed is needing to use the restroom very urgently. This has led to some embarrassing situations, like today at the grocery store. I had been noticing my hair getting thicker since I quit drinking, but now it seems to be thinning out again. If anyone else has experienced this with regards to bladder control and hair loss, please let me know. Some advice would be much appreciated.
3Patient Review
3/10/2018 I was on this medication for two months before having some routine blood tests taken. Unfortunately, these results showed that I had developed renal failure and so my doctor took me off the medication.
3Patient Review
5/12/2009 I was prescribed this medication after my blood pressure started to rise. I'm glad that it is a single pill that addresses both low potassium and high blood pressure, as I have a tendency towards low potassium levels.
3Patient Review
11/10/2009 I've only been on this medication for six months, but my blood pressure has already gone down to a normal level. I have not experienced any side effects yet, which is great. However, I did read that hair loss is a potential side effect of this drug and I am wondering if anyone else has had this problem?
2.7Patient Review
12/31/2008 Does this medication make you feel dizzy?
1.7Patient Review
2/4/2010 Not at all effective for treating my blood pressure. Also, I experienced morning stomach upset and extreme erectile dysfunction. Overall, this treatment was not helpful to me whatsoever.
1.7Patient Review
8/16/2017 I only took this drug sporadically at first, but when I started taking it more regularly is when I began to feel odd and anxious. I couldn't sleep because of how anxious I felt. These are the same symptoms I experience when taking sulfa drugs.
1.7Patient Review
5/9/2011 I felt dizzy and lightheaded after taking this medication.
1.3Patient Review
11/24/2013 I started to experience itching after only a few days of use, which increased in frequency and intensity over time. I also found myself feeling dizzy and needing to urinate more frequently. Ultimately, the side effects were too much for me to continue taking this medication.
Patient Q&A Section about spironolactone and hydrochlorothiazide
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What medications should not be taken with hydrochlorothiazide?
"The following drugs may have a negative interactions with hydrochlorothiazide: barbiturates, lithium, blood pressure drugs, cholesterol-lowering drugs, corticosteroids, diabetes drugs, narcotics, and nonsteroidal anti-inflammatory drugs (NSAIDs)."
Answered by AI
Which is better hydrochlorothiazide or spironolactone?
"Spironolactone is a better option than hydrochlorothiazide for blood pressure control and improving arterial stiffness."
Answered by AI
Are spironolactone and hydrochlorothiazide the same thing?
"Hydrochlorothiazide and spironolactone are two drugs that are often given together to help treat fluid retention. Hydrochlorothiazide is a thiazide diuretic, while spironolactone is a potassium-sparing diuretic. These two drugs work together to help reduce fluid retention and improve kidney function."
Answered by AI
Can losartan hydrochlorothiazide and spironolactone be taken together?
"If you take spironolactone and losartan at the same time, it could raise your potassium levels. If potassium gets too high, it can cause hyperkalemia, which can be deadly. Symptoms of hyperkalemia include kidney failure, muscle paralysis, and an irregular heartbeat."
Answered by AI