Spironolactone And Hydrochlorothiazide

Nephrotic Syndrome, Ascites, Hypokalemia + 14 more

Treatment

18 FDA approvals

20 Active Studies for Spironolactone And Hydrochlorothiazide

Treatment for

Nephrotic Syndrome

What is Spironolactone And Hydrochlorothiazide

SpironolactoneThe Generic name of this drug

Treatment SummaryHydrochlorothiazide is a type of medication used to treat high blood pressure and swelling caused by excess fluid. It is the most commonly prescribed diuretic but is being used less in favor of other medications, such as angiotensin converting enzyme inhibitors. Combination medications are available that contain both hydrochlorothiazide and angiotensin converting enzyme inhibitors or angiotensin II receptor blockers. Hydrochlorothiazide was approved by the FDA in 1959.

Spironolactoneis the brand name

Spironolactone And Hydrochlorothiazide Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Spironolactone

1960

288

Approved as Treatment by the FDA

Spironolactone, also known as Spironolactone, is approved by the FDA for 18 uses such as Ascites and Hypokalemia .

Ascites

Helps manage Ascites

Hypokalemia

chronic heart failure with reduced ejection fraction (NYHA Class IV)

Helps manage chronic heart failure with reduced ejection fraction (NYHA Class IV)

Swollen feet or ankles

Helps manage Edema

Cirrhosis of the Liver

Helps manage Cirrhosis of the Liver

Primary Hyperaldosteronism

Helps manage Primary Hyperaldosteronism

idiopathic hyperaldosteronism

Helps manage idiopathic hyperaldosteronism

Congestive Heart Failure (CHF)

Helps manage Congestive Heart Failure (CHF)

Hypesthesia

Helps manage chronic heart failure with reduced ejection fraction (NYHA Class IV)

Edema

Helps manage Edema

Hypesthesia

Helps manage chronic heart failure with reduced ejection fraction (NYHA Class III)

Cirrhosis

Helps manage Cirrhosis of the Liver

Hyperaldosteronism

Helps manage Primary Hyperaldosteronism

Nephrotic Syndrome

Helps manage Nephrotic Syndrome

Congestive Heart Failure

Helps manage Congestive Heart Failure (CHF)

Hypertensive disease

Helps manage High Blood Pressure (Hypertension)

Ascites

Helps manage Ascites

Hyperaldosteronism

Helps manage idiopathic hyperaldosteronism

Effectiveness

How Spironolactone And Hydrochlorothiazide Affects PatientsHydrochlorothiazide helps the body get rid of extra water by blocking the kidneys from absorbing too much salt and water. Everyone's individual dose can range from 25-100mg. It is important to be cautious when taking this drug if you have any issues with your kidneys or liver.

How Spironolactone And Hydrochlorothiazide works in the bodyHydrochlorothiazide works by blocking a protein in the kidneys called SLC12A3, which helps the body to reabsorb sodium and chloride. This protein also helps to reabsorb water. When hydrochlorothiazide blocks this protein, it reduces the amount of sodium and chloride that is reabsorbed, and also reduces the amount of water being reabsorbed. This leads to increased urination and helps to lower blood pressure.

When to interrupt dosage

The measure of Spironolactone And Hydrochlorothiazide is subject to the diagnosed condition, including Antepartum magnesium sulfate counteractive measure, blood pressure inadequately controlled with monotherapy and antihypertensives. The dosage varies as indicated by the technique of delivery (e.g. Tablet, coated - Oral or Oral) featured in the table underneath.

Condition

Dosage

Administration

Nephrotic Syndrome

50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg