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What is Twynsta
TelmisartanThe Generic name of this drug
Treatment SummaryTelmisartan is a medication used to treat high blood pressure. It works by blocking the action of angiotensin II, a hormone that narrows your blood vessels and increases your blood pressure. Recent research suggests that telmisartan may also have additional benefits related to metabolism.
Micardis HCTis the brand name
Twynsta Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Micardis HCT
Telmisartan
2000
182
Approved as Treatment by the FDA
Telmisartan, also known as Micardis HCT, is approved by the FDA for 6 uses including no initial therapy and blood pressure inadequately controlled with monotherapy .no initial therapy
Used to treat no initial therapy in combination with Amlodipine
blood pressure inadequately controlled with monotherapy
Used to treat blood pressure inadequately controlled with monotherapy in combination with Amlodipine
Cardiovascular Events
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
unable to take ACE inhibitors
prophylaxis of cardiovascular event
Effectiveness
How Twynsta Affects PatientsTelmisartan is a medication that works to block the effects of a hormone called angiotensin II. This hormone causes blood vessels to narrow and increases the production of aldosterone, a hormone which can affect the kidneys. Telmisartan blocks the hormone, allowing blood vessels to stay open and helping to regulate kidney function. Recent studies suggest that this drug may also have properties which are beneficial to metabolism and inflammation. This is currently being studied in clinical trials.
How Twynsta works in the bodyTelmisartan interferes with the binding of angiotensin II to the angiotensin II AT1-receptor. This reduces the constricting effects of angiotensin II on the blood vessels, and lowers systemic vascular resistance. Telmisartan also may act as a partial agonist of PPAR gamma, which is a target for antidiabetic drugs. This may help improve carbohydrate and lipid metabolism, and control insulin resistance without causing side effects.
When to interrupt dosage
The recommended dosage of Twynsta is subject to the diagnosed state, such as an inability to take ACE inhibitors, Hypertensive disease and Diabetic Nephropathy. Dosage relies on the administration approach (e.g. Tablet - Oral or Tablet, multilayer) detailed in the table below.Condition
Dosage
Administration
Cardiovascular Events
, 40.0 mg, 80.0 mg, 20.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, multilayer, Tablet, multilayer - Oral
unable to take ACE inhibitors
, 40.0 mg, 80.0 mg, 20.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, multilayer, Tablet, multilayer - Oral
prophylaxis of cardiovascular event
, 40.0 mg, 80.0 mg, 20.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, multilayer, Tablet, multilayer - Oral
no initial therapy
, 40.0 mg, 80.0 mg, 20.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, multilayer, Tablet, multilayer - Oral
Congestive Heart Failure
, 40.0 mg, 80.0 mg, 20.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, multilayer, Tablet, multilayer - Oral
Diabetic Nephropathy
, 40.0 mg, 80.0 mg, 20.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, multilayer, Tablet, multilayer - Oral
Hypertensive disease
, 40.0 mg, 80.0 mg, 20.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, multilayer, Tablet, multilayer - Oral
blood pressure inadequately controlled with monotherapy
, 40.0 mg, 80.0 mg, 20.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, multilayer, Tablet, multilayer - Oral
Warnings
Twynsta ContraindicationsCondition
Risk Level
Notes
Type 2 Diabetes
Do Not Combine
Common Twynsta Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Telmisartan.
Amifostine
Major
Telmisartan may increase the hypotensive activities of Amifostine.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Telmisartan.
Clomipramine
Major
The metabolism of Clomipramine can be decreased when combined with Telmisartan.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Telmisartan.
Twynsta Toxicity & Overdose RiskThe lowest toxic dose of telmisartan in rats is between 150-200mg/kg for males and 200-250mg/kg for females. Taking a large amount of telmisartan orally is not likely to cause any deaths or major changes in rats or dogs, as the highest dose tested was 2000mg/kg. People who overdose on telmisartan may experience low blood pressure, dizziness, and rapid heart rate; they could also have a slow heart rate due to stimulation of the vagus nerve.
Twynsta Novel Uses: Which Conditions Have a Clinical Trial Featuring Twynsta?
328 active clinical trials are in progress to assess the potential of Twynsta to provide blood pressure control in patients who have unsuccessfully been treated with monotherapy, cannot take ACE inhibitors, or have no initial therapy.Condition
Clinical Trials
Trial Phases
Diabetic Nephropathy
1 Actively Recruiting
Phase 4
blood pressure inadequately controlled with monotherapy
0 Actively Recruiting
Congestive Heart Failure
312 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4
unable to take ACE inhibitors
0 Actively Recruiting
prophylaxis of cardiovascular event
0 Actively Recruiting
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Cardiovascular Events
3 Actively Recruiting
Not Applicable
no initial therapy
0 Actively Recruiting
Twynsta Reviews: What are patients saying about Twynsta?
5Patient Review
11/26/2011 I've been on this medication for a little under four months now and my blood pressure has stayed within a great range. Unfortunately, in the last few weeks my feet have begun to swell and when they're swollen it's really painful to walk. I have an appointment set up tomorrow so that I can get this checked out.
5Patient Review
9/20/2013 I've only been taking this for the past two weeks, but it's already made a big difference. My previous medication didn't help me much, but this one has really worked well. I'm hopeful that it will continue to be effective.
5Patient Review
3/4/2013 I started taking Twynsta 40-10 a few years ago, but had to switch to the 40-5 dosage due to extreme ankle swelling. Thankfully, that's all cleared up now and my blood pressure is back to normal. I haven't experienced any other side effects from this medication.
5Patient Review
2/4/2013 This is the only blood pressure medication that has been able to keep my pressure low in over 40 years. I'm really pleased with this drug!
5Patient Review
4/21/2019 I've only been on this medication for the past five days, and I have already seen a significant drop in my blood pressure. It was 140/110 when I started, and after just five days it is now 127/79.
5Patient Review
3/2/2016 This medicine was really effective in getting my blood pressure under control. It never went above 130/90, which is a huge improvement from where it was before.
5Patient Review
9/2/2022 This medication has been very effective for me with few to no side effects that I am aware of.
5Patient Review
4/3/20105Patient Review
10/1/20105Patient Review
12/8/2010 I personally haven't experienced any negative side effects, like dizziness or blurred vision.
5Patient Review
3/30/2012 The medicine is great, but recently switched medical plans and the cost for a months supply is now quite expensive.
5Patient Review
10/11/2013 This drug, in combination with others, has been very successful in treating my blood pressure.
4.7Patient Review
6/8/2011 I'm very pleased with the results of this treatment.
4.7Patient Review
6/12/2012 This medication is highly effective, but unfortunately the cost has become prohibitive since I changed insurance plans.
4Patient Review
8/20/2011 I began using this medication two months ago to help control my blood pressure. At the time, several other medications had failed. Now, I'm seeing much better results and my blood pressure is more regulated.
4Patient Review
9/26/2022 I had an unfortunate reaction of hives on my lower legs after taking the recommended dosage. However, cutting the tablets in half alleviated this issue entirely. I only have a problem now if I'm in a very dry climate or low humidity, but otherwise I've been having great results with blood pressure readings.
3.7Patient Review
1/12/2015 1. Chest pain 2. Feeling light-headed and dizzy intermittently 3. Tingling of hands and right toe 4. Creeping feeling on top of head and headache located on top of head and temples (does not last long). Rare 5. Slight tremors 6. Stomach Pain (different places) 7. Early morning leg cramps (twice during the past month) 8. Aching and tender muscles (not caused by exercise) 9. Back pain
2Patient Review
4/19/2014 I have found this drug to be incredibly ineffective, and the side effects are becoming more and more severe. I would rather take my chances with high blood pressure at this point than continue down this road.
1Patient Review
1/4/2014 I was taking Twynsta for months and during that time I experienced severe cramping in both of my legs. The pain was unbearable, so I consulted a specialist who changed my medication to something else. Thankfully, the cramping stopped after that.
Patient Q&A Section about twynsta
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Twynsta good for kidneys?
"Twynsta can very rarely cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. If you experience any unexplained muscle pain, tenderness, or weakness, call your doctor right away, especially if you also have a fever, unusual fatigue, or dark-colored urine."
Answered by AI
What are side effects of Twynsta?
"If you experience any of the following side effects, call your doctor immediately: swelling of the hands, ankles, or feet; flushing (warmth, redness, or tingly feeling); drowsiness; tired feeling; back pain; nausea; diarrhea; or vomiting."
Answered by AI
What is the best time to take Twynsta?
"You can take Twynsta in the morning or evening. It works best if you take it at the same time every day."
Answered by AI
What is Twynsta tablet used for?
"This product is designed to treat high blood pressure, which can help to prevent strokes, heart attacks, and kidney problems. The product contains two medications - telmisartan, an angiotensin receptor blocker, and amlodipine, a calcium channel blocker."
Answered by AI