Brain Amyloid and Vascular Effects of Eicosapentaenoic Acid
(BRAVE-EPA Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a special type of purified fish oil on middle-aged Veterans who are at higher risk for Alzheimer's. The study will see if this fish oil can improve brain blood flow, reduce harmful markers in the fluid around the brain and spine, and boost cognitive performance. If successful, this could delay Alzheimer's onset and improve life quality for Veterans.
Will I have to stop taking my current medications?
The trial requires a 3-month period without fish oil supplements before participating. Additionally, you cannot use medications that interact with icosapent ethyl or anticoagulants. Other medications are not specifically mentioned, so it's best to discuss with the trial team.
Who Is on the Research Team?
Cynthia M. Carlsson, MD MS
Principal Investigator
William S. Middleton Memorial Veterans Hospital, Madison, WI
Are You a Good Fit for This Trial?
Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive icosapent ethyl or placebo for 18 months to assess effects on brain blood flow, CSF biomarkers, and cognitive performance
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- icosapent ethyl (IPE)
Find a Clinic Near You
Who Is Running the Clinical Trial?
VA Office of Research and Development
Lead Sponsor
University of Wisconsin, Madison
Collaborator