Hyzaar

Marfan Syndrome, Proteinuria, Hypertrophy, Left Ventricular + 6 more
Treatment
20 Active Studies for Hyzaar

What is Hyzaar

LosartanThe Generic name of this drug
Treatment SummaryHydrochlorothiazide is a diuretic drug used to treat fluid retention and high blood pressure. It is the most commonly prescribed thiazide diuretic, but is being replaced by angiotensin converting enzyme inhibitors in many cases. Combination products containing both hydrochlorothiazide and either angiotensin converting enzyme inhibitors or angiotensin II receptor blockers are widely available. The drug was approved by the FDA in 1959.
Cozaaris the brand name
image of different drug pills on a surface
Hyzaar Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Cozaar
Losartan
1995
813

Effectiveness

How Hyzaar Affects PatientsHydrochlorothiazide helps the body get rid of extra water by stopping the kidneys from reabsorbing sodium and water. The amount of hydrochlorothiazide taken can vary, but it is usually between 25 and 100mg. Care should be taken when taking this medication if the patient has poor kidney or liver function.
How Hyzaar works in the bodyHydrochlorothiazide is taken up into cells of the distal convoluted tubule in your kidneys, then transported to the lumen. Usually, sodium is reabsorbed into cells and pumped out, creating a concentration gradient that draws water back into the cells. Hydrochlorothiazide stops this process by blocking a specific transporter that moves sodium and chloride out of the cell. When this transporter is stopped, less water is reabsorbed, allowing it to pass through the kidneys and be removed from the body.

When to interrupt dosage

The proposed measure of Hyzaar is contingent upon the identified issue, including Antepartum magnesium sulfate prophylaxis, blood pressure inadequately regulated with monotherapy and antihypertensives. The extent of dosage fluctuates as per the method of delivery (e.g. Tablet, coated - Oral or Oral) featured in the table beneath.
Condition
Dosage
Administration
Type 2 Diabetes
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Ischemic Stroke
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Marfan Syndrome
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Ventricular Dysfunction
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Proteinuria
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Hypertrophy, Left Ventricular
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Diabetic Nephropathies
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Hypertensive disease
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
increased serum creatinine
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral

Warnings

Hyzaar Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Losartan may interact with Pulse Frequency
There are 20 known major drug interactions with Hyzaar.
Common Hyzaar Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Losartan.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Losartan.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Losartan.
Amifostine
Major
Losartan may increase the hypotensive activities of Amifostine.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Losartan.
Hyzaar Toxicity & Overdose RiskThe toxic dose of hydrochlorothiazide in mice and rats is greater than 10g/kg. Symptoms of an overdose include low levels of potassium, chlorine, and sodium. Treatment may involve providing fluids and electrolytes, as well as using vasopressors to treat low blood pressure and oxygen for respiratory impairment.
image of a doctor in a lab doing drug, clinical research

Hyzaar Novel Uses: Which Conditions Have a Clinical Trial Featuring Hyzaar?

158 active trials are currently assessing the potential of Hyzaar to reduce Cirrhosis, Swelling and address Congestive Heart Failure symptoms.
Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
168 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Marfan Syndrome
2 Actively Recruiting
Not Applicable
increased serum creatinine
0 Actively Recruiting
Ventricular Dysfunction
0 Actively Recruiting
Ischemic Stroke
2 Actively Recruiting
Not Applicable
Hypertensive disease
28 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Proteinuria
5 Actively Recruiting
Phase 2, Phase 3, Phase 4, Phase 1
Hypertrophy, Left Ventricular
0 Actively Recruiting
Diabetic Nephropathies
0 Actively Recruiting

Hyzaar Reviews: What are patients saying about Hyzaar?

5Patient Review
6/13/2013
Hyzaar for High Blood Pressure
This medication caused me to have cramps in my feet, which I know is from a decrease in my potassium levels. Even with supplements and increased water intake, the cramping still occurred.
5Patient Review
1/23/2016
Hyzaar for High Blood Pressure
I've been on this medication for over a decade now, and recently I developed a dry cough and sore throat. My allergist believes it is due to the hyzaar. Has anyone else experienced this side effect?
5Patient Review
6/14/2012
Hyzaar for Hypertension with Left Ventricular Hypertrophy
4.7Patient Review
4/11/2013
Hyzaar for High Blood Pressure
I had a lot of issues with leg cramps, urination frequency, and headaches while taking this medication. It also killed my sex drive, which was a huge problem. I ended up having to call my doctor to get off the medicine because it had so many side effects.
4.7Patient Review
12/21/2012
Hyzaar for High Blood Pressure
4.7Patient Review
1/11/2013
Hyzaar for High Blood Pressure
4.7Patient Review
4/9/2014
Hyzaar for High Blood Pressure
The generic Hyzaar made in India caused me some intestinal distress after taking only ten pills.
3.7Patient Review
9/20/2013
Hyzaar for High Blood Pressure
I initially had a good experience with this medication. However, now I'm having issues with cramping in my extremities as well as feeling lightheaded.
3.7Patient Review
8/8/2013
Hyzaar for High Blood Pressure
This medication has been effective for me over a long period of time.
3Patient Review
8/7/2014
Hyzaar for High Blood Pressure
I have experienced a range of negative side-effects since taking this medication, including high uric acid levels in my urine, red dots on my skin, and increased blood sugar. Additionally, I have had ocular problems!
3Patient Review
1/11/2014
Hyzaar for High Blood Pressure
My physician withdrew this medication because of low blood pressure. However, about a week later I developed gout-like symptoms in my feet and overall foot pain. Although I have less upper body pain now, I still experience quite a bit of neck pain.
3Patient Review
4/1/2014
Hyzaar for High Blood Pressure
The generic form of Losartan wasn't working for me; I experienced chest pain, lightheadedness, and my blood pressure was higher than normal.
2.7Patient Review
10/25/2012
Hyzaar for High Blood Pressure
2.7Patient Review
2/14/2013
Hyzaar for High Blood Pressure
I've found that the generic version of this drug has some nasty side effects, like an upset stomach and swollen eyes.
2.3Patient Review
7/7/2015
Hyzaar for High Blood Pressure
I had some serious side effects from this medication, including muscle weakness and blurred vision. These made everyday activities very difficult for me. Once I stopped taking the medicine, these symptoms went away; however, as soon as I started taking it again they came back just as strong. So, I stopped taking the medication and contacted my doctor.
2.3Patient Review
2/4/2019
Hyzaar for High Blood Pressure
Although this medication did lower my blood pressure, it also came with a number of nasty side effects. These include a constant dry cough, sore throat, insomnia, cold and flu symptoms, blurred vision, back and chest pains, and rapid heartbeat.
2.3Patient Review
4/24/2013
Hyzaar for High Blood Pressure
Hyzaar was the most tolerable of the twelve hypertension medications I tried, and it actually managed to keep my blood pressure in check.
2.3Patient Review
8/31/2014
Hyzaar for High Blood Pressure
I've been on this medication for 8 months and it was working great to keep my blood pressure in check. However, I started having problems recently with back pain, blurred vision, tingling and pain in joints. I'm seeing the doctor soon to get off of this!
2Patient Review
8/9/2014
Hyzaar for High Blood Pressure
I was originally prescribed a high dose, but I cut it in half because I felt terrible and my mouth was constantly dry. Even at the lower dosage, I still experienced pressure in my head and chest pain, as well as an eye hemorrhage (not sure if that's related to the medication or not). The silver lining is that it did help with the swelling in my legs.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about hyzaar

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Hyzaar being recalled?

"A pharmaceutical company has announced it will recall a medication used to treat high blood pressure after it was found to potentially increase the risk of cancer."

Answered by AI

What is the drug Hyzaar used for?

"Losartan is an angiotensin receptor blocker and works by relaxing blood vessels so that blood can flow more easily. Hydrochlorothiazide is a "water pill" (diuretic) that causes you to make more urine, which helps your body get rid of extra salt and water.

This drug lowers blood pressure and also reduces the risk of strokes in patients who have high blood pressure and an enlarged heart. The two medications in this product are losartan, an angiotensin receptor blocker, and hydrochlorothiazide, a "water pill" that helps rid the body of extra salt and water."

Answered by AI

Is Hyzaar discontinued?

"Merck has Hyzaar available. Rising has discontinued all losartan and hydrochlorothiazide presentations. Sandoz recalled one lot of losartan and hydrochlorothiazide 100 mg/25 mg tablets in 1000 count bottles due to an impurity found in the active pharmaceutical ingredient."

Answered by AI

What are the side effects of Hyzaar?

"You may feel dizzy or lightheaded as your body adjusts to the medication. You may also experience stomach pain, back pain, or a tired feeling. Some people also get a skin rash, a runny or stuffy nose, or a sore throat. Others may have a dry cough."

Answered by AI

Clinical Trials for Hyzaar

Image of U Health in Miami, United States.

Cuffless PPG Monitor for High Blood Pressure

18+
All Sexes
Miami, FL
This study aims to validate the accuracy and reliability of blood pressure (BP) estimates obtained over 24 hours using a PPG-based chest-patch device compared to the gold standard ambulatory blood pressure monitoring (ABPM) method using an upper arm cuff-based oscillometric BP device, in both hypertensive and normotensive individuals referred by their provider to undergo a 24-hours ABPM for clinical indication. The Awake/Asleep test, which is the primary test recommended for automated wearable cuffless BP devices that are cuff-calibrated (based on the 2023 European Society of Hypertension (ESH) recommendations for the validation of cuffless blood pressure measuring devices), will be conducted in this study. The secondary aim of the study is to assess the feasibility and convenience of the PPG-based device.
Waitlist Available
Has No Placebo
U Health (+1 Sites)Ziad Zoghby, M.D., M.B.A.Biobeat Technologies Ltd.
Image of University of California, Los Angeles in Los Angeles, United States.

Tailored DPP for Prediabetes

17 - 25
All Sexes
Los Angeles, CA
The goal of this study is to enhance reach and uptake of diabetes prevention among young adults, with a focus on recruiting underserved and high-need students who face additional challenges, including food and financial insecurity. The specific aims are: Aim 1 - Evaluate the efficacy of an AYA-tailored version of the UC DPP for mitigating type 2 diabetes risk (i.e., weight change) in a pre/post pilot trial. The investigators hypothesize that the AYA-tailored intervention will be effective at producing 5% weight loss from baseline to program completion (at 9-months). Aim 2 - Assess the feasibility and acceptability of an AYA-tailored version of the UC DPP program. The investigators hypothesize that it will be feasible to recruit the desired number of participants given proposed innovative outreach strategies, and that the AYA-tailored intervention will be deemed acceptable to participants both qualitatively and in regards to their retention in the program at rates similar to the larger UC DPP. The investigators will recruit 80 UCLA undergraduate students. Participants will be asked to complete a brief screening online form to assess eligibility and to collect contact information. The PI and/or Research Assistants (RAs) will reach out to eligible participants to obtain informed consent and enroll them in the pilot trial. The investigators will randomize participants to the tailored DPP cohort vs control cohort. Control participants will be offered the opportunity to participate in the tailored DPP in the following academic year. The tailored DPP intervention will be online and asynchronously. Participants will be asked to complete the intervention lessons on their own time. Each lesson typically takes on average 15 minutes to complete. Control group will receive each intervention materials via e-mail for participants to review on their own time and will receive acceptability surveys. The interventions for the control group will be remote. A research assistant will meet with control participants via Zoom to explain the intervention materials. Control group will receive access to a study habits intervention, alcohol use intervention, and financial literacy intervention. At the end of each quarter (Fall, Winter, and Spring), both control and intervention participants will receive an email with a unique link to a brief REDCap survey to ascertain acceptability of sessions/lessons. Furthermore, participants will complete baseline and 9-month follow-up assessments. Participants will complete a 30 minute questionnaire and height/weight measurements will be collected by a RA. Participants will be asked to self-report weight and physical activity at the end of the fall and winter quarter; data will be collected via brief REDCap survey.
Recruiting
Has No Placebo
University of California, Los AngelesLauren E Wisk, PhD
Have you considered Hyzaar clinical trials? We made a collection of clinical trials featuring Hyzaar, we think they might fit your search criteria.Go to Trials
Image of Medpace Clinical Pharmaology Unit in Cincinnati, United States.

PATAS for Type 2 Diabetes

18 - 55
All Sexes
Cincinnati, OH
The primary objective of Part 1 of this study is to evaluate safety and tolerability of single subcutaneous (SC) doses of PATAS in healthy subjects. The secondary objective of Part 1 of this study is to determine the pharmacokinetics (PK) of single SC doses of PATAS in healthy subjects. The primary objectives of Part 2 of this study are to evaluate the safety and tolerability of 4 weekly SC doses of PATAS in subjects with T2D; and to determine the PK and pharmacodynamics (PD) of 4 weekly SC doses of PATAS in subjects with T2D. The secondary objectives of Part 2 of this study are to evaluate the potential effect of multiple SC doses of PATAS on markers of glycemic control, as measured by glucose levels, insulin levels, and other metabolomic biomarkers; and to characterize the adverse event (AE) profiles of the various dose levels of PATAS.
Phase 1
Waitlist Available
Medpace Clinical Pharmaology UnitVincent Marion, Ph.D.AdipoPharma LLC
Image of The Worship Center Cristian Church in Birmingham, United States.

Black Impact for Heart Health

18+
Male
Birmingham, AL
The goal of this clinical trial is to evaluate the implementation and effectiveness of the Black Impact program-a church-based cardiovascular health (CVH) intervention-in Black men aged 35-70 who are at risk for heart disease, diabetes, obesity, and related conditions. The main questions this study aims to answer are: * Does participation in the Black Impact program improve cardiovascular health metrics (e.g., blood pressure, cholesterol, blood sugar) and health behaviors among Black men at The Worship Center Christian Church (TWC)? * What factors influence the adoption, delivery, and sustainability of the Black Impact program in a faith-based setting? Researchers will compare an immediate-start intervention group and a delayed-start (waitlist control) group to assess both short-term health outcomes and program implementation factors. Participants will: * Attend a 90-minute weekly session for 24 weeks, including 45 minutes of physical activity led by a certified trainer and 45 minutes of health education delivered by trained coaches. * Receive one-on-one support from a community health worker to reduce barriers to care and engage with primary care. * Complete biometric health screenings and surveys at baseline, 12 weeks, and 24 weeks to assess clinical and behavioral outcomes. * Use a smartwatch, blood pressure cuff, and other tools to track progress in real time. * Participate in exit focus groups or interviews to share feedback about the intervention. * A subset of TWC leaders and interventionists (N=15) will also be interviewed to assess implementation, resource needs, and sustainability. This study uses the RE-AIM framework to assess Reach, Effectiveness, Adoption, Implementation, and Maintenance, and aims to inform scalable strategies for improving CVH among Black men in trusted community settings.
Waitlist Available
Has No Placebo
The Worship Center Cristian Church
Have you considered Hyzaar clinical trials? We made a collection of clinical trials featuring Hyzaar, we think they might fit your search criteria.Go to Trials
Have you considered Hyzaar clinical trials? We made a collection of clinical trials featuring Hyzaar, we think they might fit your search criteria.Go to Trials
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Terms of Service·Privacy Policy·Cookies·Security