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What is Hyzaar
LosartanThe Generic name of this drug
Treatment SummaryHydrochlorothiazide is a diuretic drug used to treat fluid retention and high blood pressure. It is the most commonly prescribed thiazide diuretic, but is being replaced by angiotensin converting enzyme inhibitors in many cases. Combination products containing both hydrochlorothiazide and either angiotensin converting enzyme inhibitors or angiotensin II receptor blockers are widely available. The drug was approved by the FDA in 1959.
Cozaaris the brand name
Hyzaar Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Cozaar
Losartan
1995
813
Effectiveness
How Hyzaar Affects PatientsHydrochlorothiazide helps the body get rid of extra water by stopping the kidneys from reabsorbing sodium and water. The amount of hydrochlorothiazide taken can vary, but it is usually between 25 and 100mg. Care should be taken when taking this medication if the patient has poor kidney or liver function.
How Hyzaar works in the bodyHydrochlorothiazide is taken up into cells of the distal convoluted tubule in your kidneys, then transported to the lumen. Usually, sodium is reabsorbed into cells and pumped out, creating a concentration gradient that draws water back into the cells. Hydrochlorothiazide stops this process by blocking a specific transporter that moves sodium and chloride out of the cell. When this transporter is stopped, less water is reabsorbed, allowing it to pass through the kidneys and be removed from the body.
When to interrupt dosage
The proposed measure of Hyzaar is contingent upon the identified issue, including Antepartum magnesium sulfate prophylaxis, blood pressure inadequately regulated with monotherapy and antihypertensives. The extent of dosage fluctuates as per the method of delivery (e.g. Tablet, coated - Oral or Oral) featured in the table beneath.Condition
Dosage
Administration
increased serum creatinine
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Diabetic Nephropathy
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Type 2 Diabetes
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Marfan Syndrome
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Left Ventricular Hypertrophy
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Hypertensive disease
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Ischemic Stroke
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Ventricular Dysfunction
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Proteinuria
50.0 mg, , 100.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Warnings
Hyzaar ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Losartan may interact with Pulse Frequency
Common Hyzaar Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Losartan.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Losartan.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Losartan.
Amifostine
Major
Losartan may increase the hypotensive activities of Amifostine.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Losartan.
Hyzaar Toxicity & Overdose RiskThe toxic dose of hydrochlorothiazide in mice and rats is greater than 10g/kg. Symptoms of an overdose include low levels of potassium, chlorine, and sodium. Treatment may involve providing fluids and electrolytes, as well as using vasopressors to treat low blood pressure and oxygen for respiratory impairment.
Hyzaar Novel Uses: Which Conditions Have a Clinical Trial Featuring Hyzaar?
158 active trials are currently assessing the potential of Hyzaar to reduce Cirrhosis, Swelling and address Congestive Heart Failure symptoms.Condition
Clinical Trials
Trial Phases
Proteinuria
5 Actively Recruiting
Phase 2, Phase 3, Phase 4
Ischemic Stroke
1 Actively Recruiting
Not Applicable
Diabetic Nephropathy
1 Actively Recruiting
Phase 4
Marfan Syndrome
3 Actively Recruiting
Not Applicable
increased serum creatinine
0 Actively Recruiting
Ventricular Dysfunction
14 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Early Phase 1
Type 2 Diabetes
192 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Left Ventricular Hypertrophy
3 Actively Recruiting
Not Applicable, Phase 4
Hyzaar Reviews: What are patients saying about Hyzaar?
5Patient Review
6/13/2013 This medication caused me to have cramps in my feet, which I know is from a decrease in my potassium levels. Even with supplements and increased water intake, the cramping still occurred.
5Patient Review
1/23/2016 I've been on this medication for over a decade now, and recently I developed a dry cough and sore throat. My allergist believes it is due to the hyzaar. Has anyone else experienced this side effect?
5Patient Review
6/14/20124.7Patient Review
4/11/2013 I had a lot of issues with leg cramps, urination frequency, and headaches while taking this medication. It also killed my sex drive, which was a huge problem. I ended up having to call my doctor to get off the medicine because it had so many side effects.
4.7Patient Review
12/21/20124.7Patient Review
1/11/20134.7Patient Review
4/9/2014 The generic Hyzaar made in India caused me some intestinal distress after taking only ten pills.
3.7Patient Review
9/20/2013 I initially had a good experience with this medication. However, now I'm having issues with cramping in my extremities as well as feeling lightheaded.
3.7Patient Review
8/8/2013 This medication has been effective for me over a long period of time.
3Patient Review
8/7/2014 I have experienced a range of negative side-effects since taking this medication, including high uric acid levels in my urine, red dots on my skin, and increased blood sugar. Additionally, I have had ocular problems!
3Patient Review
1/11/2014 My physician withdrew this medication because of low blood pressure. However, about a week later I developed gout-like symptoms in my feet and overall foot pain. Although I have less upper body pain now, I still experience quite a bit of neck pain.
3Patient Review
4/1/2014 The generic form of Losartan wasn't working for me; I experienced chest pain, lightheadedness, and my blood pressure was higher than normal.
2.7Patient Review
10/25/20122.7Patient Review
2/14/2013 I've found that the generic version of this drug has some nasty side effects, like an upset stomach and swollen eyes.
2.3Patient Review
7/7/2015 I had some serious side effects from this medication, including muscle weakness and blurred vision. These made everyday activities very difficult for me. Once I stopped taking the medicine, these symptoms went away; however, as soon as I started taking it again they came back just as strong. So, I stopped taking the medication and contacted my doctor.
2.3Patient Review
2/4/2019 Although this medication did lower my blood pressure, it also came with a number of nasty side effects. These include a constant dry cough, sore throat, insomnia, cold and flu symptoms, blurred vision, back and chest pains, and rapid heartbeat.
2.3Patient Review
4/24/2013 Hyzaar was the most tolerable of the twelve hypertension medications I tried, and it actually managed to keep my blood pressure in check.
2.3Patient Review
8/31/2014 I've been on this medication for 8 months and it was working great to keep my blood pressure in check. However, I started having problems recently with back pain, blurred vision, tingling and pain in joints. I'm seeing the doctor soon to get off of this!
2Patient Review
8/9/2014 I was originally prescribed a high dose, but I cut it in half because I felt terrible and my mouth was constantly dry. Even at the lower dosage, I still experienced pressure in my head and chest pain, as well as an eye hemorrhage (not sure if that's related to the medication or not). The silver lining is that it did help with the swelling in my legs.
Patient Q&A Section about hyzaar
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Hyzaar being recalled?
"A pharmaceutical company has announced it will recall a medication used to treat high blood pressure after it was found to potentially increase the risk of cancer."
Answered by AI
What is the drug Hyzaar used for?
"Losartan is an angiotensin receptor blocker and works by relaxing blood vessels so that blood can flow more easily. Hydrochlorothiazide is a "water pill" (diuretic) that causes you to make more urine, which helps your body get rid of extra salt and water.
This drug lowers blood pressure and also reduces the risk of strokes in patients who have high blood pressure and an enlarged heart. The two medications in this product are losartan, an angiotensin receptor blocker, and hydrochlorothiazide, a "water pill" that helps rid the body of extra salt and water."
Answered by AI
Is Hyzaar discontinued?
"Merck has Hyzaar available. Rising has discontinued all losartan and hydrochlorothiazide presentations. Sandoz recalled one lot of losartan and hydrochlorothiazide 100 mg/25 mg tablets in 1000 count bottles due to an impurity found in the active pharmaceutical ingredient."
Answered by AI
What are the side effects of Hyzaar?
"You may feel dizzy or lightheaded as your body adjusts to the medication. You may also experience stomach pain, back pain, or a tired feeling. Some people also get a skin rash, a runny or stuffy nose, or a sore throat. Others may have a dry cough."
Answered by AI