Lotrel

Congestive Heart Failure, Primary Hypercholesterolemia, Coronary Disease + 13 more
Treatment
5 FDA approvals
20 Active Studies for Lotrel

What is Lotrel

AmlodipineThe Generic name of this drug
Treatment SummaryAmlodipine is a medication used to treat high blood pressure and chest pain. It belongs to a class of drugs called dihydropyridine calcium channel blockers, which are known for having fewer side effects than other types of hypertension medications. Amlodipine has antioxidant properties and works by increasing nitric oxide production, which helps to relax and widen the blood vessels, reducing blood pressure. It was approved by the FDA in 1987 and is often prescribed in a single daily dose.
Norvascis the brand name
image of different drug pills on a surface
Lotrel Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Norvasc
Amlodipine
1992
1199

Approved as Treatment by the FDA

Amlodipine, also known as Norvasc, is approved by the FDA for 5 uses like Coronary Disease and Coronary Artery Disease (CAD) .
Coronary Disease
Used to treat Coronary Artery Disease (CAD) in combination with Atorvastatin
Coronary Artery Disease (CAD)
Used to treat Coronary Artery Disease (CAD) in combination with Atorvastatin
Coronary Artery Disease
Used to treat angiographically documented disease in combination with Atorvastatin
Vasospastic Angina
Used to treat Vasospastic Angina in combination with Atorvastatin
Angina, Stable
Used to treat Chronic Stable Angina Pectoris in combination with Atorvastatin

Effectiveness

How Lotrel Affects PatientsAmlodipine helps reduce blood pressure by blocking certain calcium channels in the body. It is usually taken once daily and its effects last up to 24 hours. Taking this drug does not usually affect heart rate or blood pressure in people with chronic stable angina. Amlodipine also helps relieve chest pain associated with angina by increasing exercise time, decreasing the frequency of angina attacks, and lowering the need for nitroglycerin tablets.
How Lotrel works in the bodyAmlodipine is a type of drug that helps to lower blood pressure and reduce the symptoms of angina. It works by blocking the influx of calcium ions into both cardiac and vascular smooth muscle cells, causing them to relax and widen. This results in a decrease in total peripheral resistance and myocardial oxygen use, as well as an increase in myocardial oxygen delivery in areas with ischemia. Additionally, amlodipine can cause coronary vessels to widen, reducing coronary vasoconstriction.

When to interrupt dosage

The endorsed dosage of Lotrel is contingent upon the diagnosed condition, including inadequate response to diet, High Cardiovascular Risk and Lifestyle Modification. The amount of dosage will vary, depending on the method of administration (e.g. Tablet, film coated or Tablet) detailed in the table below.
Condition
Dosage
Administration
High Cardiovascular Risk
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution - Oral, Solution, Suspension - Oral, Suspension
Dyslipidemias
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution - Oral, Solution, Suspension - Oral, Suspension
Pharmacotherapy
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution - Oral, Solution, Suspension - Oral, Suspension
Homozygous Familial Hypercholesterolemia
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution - Oral, Solution, Suspension - Oral, Suspension
Vasospastic Angina
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution - Oral, Solution, Suspension - Oral, Suspension
inadequate response to diet
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution - Oral, Solution, Suspension - Oral, Suspension
Congestive Heart Failure
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution - Oral, Solution, Suspension - Oral, Suspension
Primary Hypercholesterolemia
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution - Oral, Solution, Suspension - Oral, Suspension
Coronary Disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution - Oral, Solution, Suspension - Oral, Suspension
Cardiovascular Events
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution - Oral, Solution, Suspension - Oral, Suspension
Lifestyle Modification
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution - Oral, Solution, Suspension - Oral, Suspension
Hypertensive disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution - Oral, Solution, Suspension - Oral, Suspension
Hypertensive disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution - Oral, Solution, Suspension - Oral, Suspension
Angina, Stable
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution - Oral, Solution, Suspension - Oral, Suspension
Coronary Artery Disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution - Oral, Solution, Suspension - Oral, Suspension
Dyslipidemias
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution - Oral, Solution, Suspension - Oral, Suspension

Warnings

Lotrel has one contraindication, so it should not be combined with the circumstances specified in the following table.Lotrel Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Amlodipine may interact with Pulse Frequency
There are 20 known major drug interactions with Lotrel.
Common Lotrel Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Amlodipine may increase the hypotensive activities of Amifostine.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Hydroxyzine.
Mobocertinib
Major
The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Mobocertinib.
Ziprasidone
Major
The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Ziprasidone.
Abafungin
Minor
The therapeutic efficacy of Abafungin can be increased when used in combination with Amlodipine.
Lotrel Toxicity & Overdose RiskThe toxic dose of amlodipine in mice is 37 mg/kg. An overdose may cause a high level of blood vessel widening, a rapid heartbeat, and severe low blood pressure. Animal studies have not found any cancer-causing effects, although the drug has not been tested on pregnant or lactating women. Mothers should not take amlodipine while nursing.

Lotrel Novel Uses: Which Conditions Have a Clinical Trial Featuring Lotrel?

46 active studies are presently evaluating the potential of Lotrel to reduce High Cardiovascular Risk, Vasospastic Angina and Coronary Artery Disease (CAD).
Condition
Clinical Trials
Trial Phases
Congestive Heart Failure
186 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1
Hypertensive disease
3 Actively Recruiting
Not Applicable, Phase 3
inadequate response to diet
0 Actively Recruiting
Dyslipidemias
1 Actively Recruiting
Phase 2
Homozygous Familial Hypercholesterolemia
2 Actively Recruiting
Phase 3
Vasospastic Angina
1 Actively Recruiting
Phase 2, Phase 3
Dyslipidemias
0 Actively Recruiting
Primary Hypercholesterolemia
8 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Coronary Disease
1 Actively Recruiting
Not Applicable
Lifestyle Modification
2 Actively Recruiting
Not Applicable
Angina, Stable
0 Actively Recruiting
Hypertensive disease
28 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Coronary Artery Disease
0 Actively Recruiting
High Cardiovascular Risk
2 Actively Recruiting
Phase 2, Phase 3
Cardiovascular Events
4 Actively Recruiting
Not Applicable
Pharmacotherapy
0 Actively Recruiting

Lotrel Reviews: What are patients saying about Lotrel?

5Patient Review
3/12/2013
Lotrel for High Blood Pressure
I take Lotrel 5/20 (reduced from 5/40) in morning and BP is a little higher first in morning. Doc sugested taking it evening/night. Any comment would be appreciated
5Patient Review
7/29/2013
Lotrel for High Blood Pressure
This medication has been great for controlling my blood pressure, but I have noticed some negative effects on my kidney function.
5Patient Review
7/2/2012
Lotrel for High Blood Pressure
5Patient Review
10/29/2012
Lotrel for High Blood Pressure
5Patient Review
1/24/2014
Lotrel for High Blood Pressure
I'm really annoyed with the dry cough that seems to be getting worse.
5Patient Review
12/29/2012
Lotrel for High Blood Pressure
This medication effectively controls my blood pressure. The only downside is that I sometimes feel dizzy, which can be a problem if I'm driving.
4.7Patient Review
7/18/2012
Lotrel for High Blood Pressure
4Patient Review
3/31/2013
Lotrel for High Blood Pressure
I've been using the generic Lotrel for hypertension for about five years now. My blood pressure usually falls within the "normal" range, but there are times when it spikes up higher than usual. I think it might be time to talk to my doctor about potentially trying a different medication.
3.7Patient Review
1/10/2014
Lotrel for High Blood Pressure
While this drug has lowered my blood pressure, I have experienced some severe side effects. These include swelling in my calves and feet, aching joints, muscle fatigue, and headaches. My urine has also changed coloration, which suggests to me that this medication is having a negative effect on my kidneys. I've been on the drug for four months now and am hopeful that my new doctor will be able to find a better solution for treating blood pressure without the use of Lotrel.
3.7Patient Review
11/24/2012
Lotrel for High Blood Pressure
I've been taking this drug for over a decade to help control my high blood pressure. It's effective and I haven't experienced any negative side effects.
3.7Patient Review
11/30/2019
Lotrel for High Blood Pressure
I am experiencing dry coughing spells that are quite bothersome.
3Patient Review
10/15/2013
Lotrel for High Blood Pressure
Lotrel is the only drug that has been effective in treating my high blood pressure. I would love to be able to get it cheaper, as I had to pay $200 out of pocket despite having UnitedHealthcare prescription coverage.
3Patient Review
5/19/2014
Lotrel for High Blood Pressure
I'm starting to wonder if Lotrel is the reason why my white blood cell count has been low lately.
2.3Patient Review
6/25/2014
Lotrel for High Blood Pressure
I have a throat that's been making me cough nonstop for the past two months. It's gotten to the point where my legs hurt from all the coughing. I really don't like this medication.
2Patient Review
10/20/2013
Lotrel for High Blood Pressure
I've been taking Lotrel 5/20 for 10 years with great results. Recently, I switched to the generic brand and am still seeing positive results while spending less money.
1Patient Review
9/16/2012
Lotrel for High Blood Pressure
1Patient Review
11/25/2014
Lotrel for High Blood Pressure
After taking this medication for a few months, my blood pressure started to rise. My numbers would be 158/108. I was also constantly dehydrated and had swollen fingers, ankles, and feet.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about lotrel

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Lotrel a good blood pressure medication?

"Both medications in Lotrel, amlodipine and benazepril, are recommended as first-choice medications to help lower blood pressure. The combination of these two medications lowers blood pressure better than either one by itself."

Answered by AI

What medications should not be taken with Lotrel?

"Some products that may interact with this drug include: aliskiren, certain drugs that weaken the immune system/increase the risk of infection (such as everolimus, sirolimus), lithium, drugs that may increase the level of potassium in the blood (such as ARBs including losartan/valsartan, birth control pills containing drospirenone)."

Answered by AI

Does Lotrel contain a diuretic?

"Lotrel is a combination of Lotensin and Norvasc. The other pill contains Lotensin and a diuretic called hydrochlorothiazide."

Answered by AI

What are the side effects of Lotrel?

"The symptoms of the flu can include coughing, dizziness, lightheadedness, headache, and swelling of the hands/ankles/feet."

Answered by AI

Clinical Trials for Lotrel

Image of Yale New Haven Hospital-St. Raphael Campus in New Haven, United States.

Dapagliflozin for Heart Failure

18 - 85
All Sexes
New Haven, CT
The overall objective of this study is to determine whether the addition of SGLT2 inhibitors to usual care in hospitalized patients with heart failure associated acute kidney injury is safe and efficacious. Investigators will assess if SGLT2 inhibition improves a composite cardio-renal outcome (mortality, dialysis, AKI progression, decongestion metrics, heart failure symptoms). Secondary objectives of this study are to compare individual components of the composite outcome as well as changes in biomarkers of kidney injury, inflammation, repair and oxidative stress between those exposed to the SGLT2 inhibitor vs placebo.
Phase 2
Waitlist Available
Yale New Haven Hospital-St. Raphael Campus (+1 Sites)Abinet Aklilu, MD
Image of Cambride Cardiac Care Centre in Cambridge, Canada.

Finerenone for Heart Failure

18+
All Sexes
Cambridge, Canada
The goal of this clinical trial is to learn if the drug finerenone (Karendia) can improve heart function in participants who are at risk for heart and kidney disease. The main question it aims to answer is whether adding finerenone to standard-of-care heart failure medical therapies will beneficially alter the heart structure and function of people who have risk factors for heart and kidney complications and whose left side of the heart is enlarged. The researchers will compare finerenone to a placebo (a look-alike substance that contains no drug) to see if finerenone improves heart structure and function. Participants will: * take a finerenone or a placebo tablet once a day for 12 months * have a cardiac magnetic resonance imaging (cMRI; a safe, non-invasive scan to measure heart mass, stiffness and function) test at the beginning of the study and 12 months later * visit the clinic after one, three, six and twelve months to assess overall health and/or perform blood or urine tests
Phase 3
Waitlist Available
Cambride Cardiac Care Centre (+2 Sites)Subodh Verma, MD, PhDBayer
Image of Lakeland Regional Hospital in Lakeland, United States.

Furosemide for Heart Failure

18+
All Sexes
Lakeland, FL
The goal of this clinical trial is to learn if increasing the dose of diuretics to achieve a higher urine sodium target produces better clinical results when treating patients hospitalized with acute heart failure when compared to lower urine sodium target and standard of care. The main questions it aims to answer are: 1. Does targeting a higher urine sodium goal achieve greater natriuresis and diuresis? 2. Does targeting a higher urine sodium goal reduce frequency of hospital readmissions? 3. Does targeting a higher urine sodium goal reduce hospital length of stay? Researchers will compare natriuresis-guided arms with standard of care to see if targeting higher natriuresis goals improves significantly over current practice. Participants will submit urine samples at routine intervals after being given diuretics to evaluate urine sodium concentration. If urine sodium is low then diuretic dose will be increased.
Phase 4
Waitlist Available
Lakeland Regional HospitalAnas Bizanti, MD
Have you considered Lotrel clinical trials? We made a collection of clinical trials featuring Lotrel, we think they might fit your search criteria.Go to Trials
Image of U Health in Miami, United States.

Cuffless PPG Monitor for High Blood Pressure

18+
All Sexes
Miami, FL
This study aims to validate the accuracy and reliability of blood pressure (BP) estimates obtained over 24 hours using a PPG-based chest-patch device compared to the gold standard ambulatory blood pressure monitoring (ABPM) method using an upper arm cuff-based oscillometric BP device, in both hypertensive and normotensive individuals referred by their provider to undergo a 24-hours ABPM for clinical indication. The Awake/Asleep test, which is the primary test recommended for automated wearable cuffless BP devices that are cuff-calibrated (based on the 2023 European Society of Hypertension (ESH) recommendations for the validation of cuffless blood pressure measuring devices), will be conducted in this study. The secondary aim of the study is to assess the feasibility and convenience of the PPG-based device.
Waitlist Available
Has No Placebo
U Health (+1 Sites)Ziad Zoghby, M.D., M.B.A.Biobeat Technologies Ltd.
Have you considered Lotrel clinical trials? We made a collection of clinical trials featuring Lotrel, we think they might fit your search criteria.Go to Trials
Image of Los Angeles General Medical Center in Los Angeles, United States.

Supportive Management for Heart Failure and Methamphetamine Addiction

18+
All Sexes
Los Angeles, CA
Heart failure (HF) affects over 6 million people in the US and is a major cause of both hospital admissions and death. HF has many causes and contributing factors. One of the most aggressive forms of HF is associated with methamphetamine abuse, which has become its own epidemic in the US over the past twenty years. People who use methamphetamine tend to develop HF at a much younger age, with more severe disease and more serious consequences. A recent analysis using nationwide data, methamphetamine use doubled the risk of death or hospitalizations compared to non-users in patients with HF. Thus, methamphetamine users with HF represent a very high-risk group of patients from a healthcare perspective. HF may be reversible in some patients who use methamphetamine if patients can achieve 1) abstain from further methamphetamine use and 2) consistently take all the medications that can improve HF. These two goals are very difficult to achieve in practice, as the care of both methamphetamine addiction and HF requires specialized medical expertise and intensive regular follow up of patients. In general, achievement of one goal is not possible without the other. Patients who use methamphetamine have poor adherence to medical follow-up and therapies, and abstinence from methamphetamine is difficult to maintain. This is further complicated because the current model of HF care does not incorporate treatment for methamphetamine use. The current study proposes to launch a multidisciplinary clinic that treats both HF and methamphetamine use disorder at the same time. The HF care will be led by a cardiologist while the methamphetamine use treatment will be led by a psychiatric clinical pharmacist trained in addiction medicine. State-of-the-art HF care will include optimization of four pillar HF medications. Methamphetamine use treatment will include counseling and incentivized abstinence known as contingency management (CM). The investigators will manage the patients in the clinic for 6 months total. The investigators are interested in demonstrating that this integrated clinic model will result in improved delivery of care for these patients by reporting the rates of successful abstinence from methamphetamine, improved optimization of the four HF medications, and enhanced patient reported quality of life over the 6 months of follow up. The investigators will also collect data on the costs associated with providing this level of care and estimate a range of potential cost-savings.
Waitlist Available
Has No Placebo
Los Angeles General Medical Center (+1 Sites)Tien Ng, PharmD
Have you considered Lotrel clinical trials? We made a collection of clinical trials featuring Lotrel, we think they might fit your search criteria.Go to Trials
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