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What is Lotrel
AmlodipineThe Generic name of this drug
Treatment SummaryAmlodipine is a medication used to treat high blood pressure and chest pain. It belongs to a class of drugs called dihydropyridine calcium channel blockers, which are known for having fewer side effects than other types of hypertension medications. Amlodipine has antioxidant properties and works by increasing nitric oxide production, which helps to relax and widen the blood vessels, reducing blood pressure. It was approved by the FDA in 1987 and is often prescribed in a single daily dose.
Norvascis the brand name
Lotrel Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Norvasc
Amlodipine
1992
1199
Approved as Treatment by the FDA
Amlodipine, also known as Norvasc, is approved by the FDA for 4 uses like angiographically documented disease and Chronic Stable Angina Pectoris .angiographically documented disease
Used to treat angiographically documented disease in combination with Atorvastatin
Chronic Stable Angina Pectoris
Used to treat Chronic Stable Angina Pectoris in combination with Atorvastatin
Coronary Artery Disease (CAD)
Used to treat Coronary Artery Disease (CAD) in combination with Atorvastatin
Vasospastic Angina
Used to treat Vasospastic Angina in combination with Atorvastatin
Effectiveness
How Lotrel Affects PatientsAmlodipine helps reduce blood pressure by blocking certain calcium channels in the body. It is usually taken once daily and its effects last up to 24 hours. Taking this drug does not usually affect heart rate or blood pressure in people with chronic stable angina. Amlodipine also helps relieve chest pain associated with angina by increasing exercise time, decreasing the frequency of angina attacks, and lowering the need for nitroglycerin tablets.
How Lotrel works in the bodyAmlodipine is a type of drug that helps to lower blood pressure and reduce the symptoms of angina. It works by blocking the influx of calcium ions into both cardiac and vascular smooth muscle cells, causing them to relax and widen. This results in a decrease in total peripheral resistance and myocardial oxygen use, as well as an increase in myocardial oxygen delivery in areas with ischemia. Additionally, amlodipine can cause coronary vessels to widen, reducing coronary vasoconstriction.
When to interrupt dosage
The endorsed dosage of Lotrel is contingent upon the diagnosed condition, including inadequate response to diet, High Cardiovascular Risk and Lifestyle Modification. The amount of dosage will vary, depending on the method of administration (e.g. Tablet, film coated or Tablet) detailed in the table below.Condition
Dosage
Administration
Hypertensive disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
angiographically documented disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Congestive Heart Failure
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Primary Hypercholesterolemia
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Coronary Artery Disease (CAD)
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Cardiovascular Events
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Lifestyle Modification
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Vasospastic Angina
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Hypertensive disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
High Cardiovascular Risk
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Dyslipidemias
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Chronic Stable Angina Pectoris
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
inadequate response to diet
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Mixed Dyslipidaemia
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Pharmacotherapy
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Homozygous Familial Hypercholesterolemia
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Warnings
Lotrel has one contraindication, so it should not be combined with the circumstances specified in the following table.Lotrel ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Amlodipine may interact with Pulse Frequency
Common Lotrel Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Amlodipine may increase the hypotensive activities of Amifostine.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Hydroxyzine.
Mobocertinib
Major
The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Mobocertinib.
Ziprasidone
Major
The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Ziprasidone.
Abafungin
Minor
The therapeutic efficacy of Abafungin can be increased when used in combination with Amlodipine.
Lotrel Toxicity & Overdose RiskThe toxic dose of amlodipine in mice is 37 mg/kg. An overdose may cause a high level of blood vessel widening, a rapid heartbeat, and severe low blood pressure. Animal studies have not found any cancer-causing effects, although the drug has not been tested on pregnant or lactating women. Mothers should not take amlodipine while nursing.
Lotrel Novel Uses: Which Conditions Have a Clinical Trial Featuring Lotrel?
46 active studies are presently evaluating the potential of Lotrel to reduce High Cardiovascular Risk, Vasospastic Angina and Coronary Artery Disease (CAD).Condition
Clinical Trials
Trial Phases
inadequate response to diet
0 Actively Recruiting
Primary Hypercholesterolemia
16 Actively Recruiting
Early Phase 1, Not Applicable, Phase 3, Phase 2
Hypertensive disease
2 Actively Recruiting
Not Applicable
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Mixed Dyslipidaemia
0 Actively Recruiting
Congestive Heart Failure
312 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4
Homozygous Familial Hypercholesterolemia
4 Actively Recruiting
Phase 3, Phase 2
Vasospastic Angina
0 Actively Recruiting
Coronary Artery Disease (CAD)
1 Actively Recruiting
Not Applicable
High Cardiovascular Risk
1 Actively Recruiting
Phase 2
Pharmacotherapy
0 Actively Recruiting
Dyslipidemias
1 Actively Recruiting
Phase 2
Cardiovascular Events
3 Actively Recruiting
Not Applicable
angiographically documented disease
0 Actively Recruiting
Lifestyle Modification
1 Actively Recruiting
Not Applicable
Chronic Stable Angina Pectoris
1 Actively Recruiting
Not Applicable
Lotrel Reviews: What are patients saying about Lotrel?
5Patient Review
3/12/2013 I take Lotrel 5/20 (reduced from 5/40) in morning and BP is a little higher first in morning. Doc sugested taking it evening/night. Any comment would be appreciated
5Patient Review
7/29/2013 This medication has been great for controlling my blood pressure, but I have noticed some negative effects on my kidney function.
5Patient Review
7/2/20125Patient Review
10/29/20125Patient Review
1/24/2014 I'm really annoyed with the dry cough that seems to be getting worse.
5Patient Review
12/29/2012 This medication effectively controls my blood pressure. The only downside is that I sometimes feel dizzy, which can be a problem if I'm driving.
4.7Patient Review
7/18/20124Patient Review
3/31/2013 I've been using the generic Lotrel for hypertension for about five years now. My blood pressure usually falls within the "normal" range, but there are times when it spikes up higher than usual. I think it might be time to talk to my doctor about potentially trying a different medication.
3.7Patient Review
1/10/2014 While this drug has lowered my blood pressure, I have experienced some severe side effects. These include swelling in my calves and feet, aching joints, muscle fatigue, and headaches. My urine has also changed coloration, which suggests to me that this medication is having a negative effect on my kidneys. I've been on the drug for four months now and am hopeful that my new doctor will be able to find a better solution for treating blood pressure without the use of Lotrel.
3.7Patient Review
11/24/2012 I've been taking this drug for over a decade to help control my high blood pressure. It's effective and I haven't experienced any negative side effects.
3.7Patient Review
11/30/2019 I am experiencing dry coughing spells that are quite bothersome.
3Patient Review
10/15/2013 Lotrel is the only drug that has been effective in treating my high blood pressure. I would love to be able to get it cheaper, as I had to pay $200 out of pocket despite having UnitedHealthcare prescription coverage.
3Patient Review
5/19/2014 I'm starting to wonder if Lotrel is the reason why my white blood cell count has been low lately.
2.3Patient Review
6/25/2014 I have a throat that's been making me cough nonstop for the past two months. It's gotten to the point where my legs hurt from all the coughing. I really don't like this medication.
2Patient Review
10/20/2013 I've been taking Lotrel 5/20 for 10 years with great results. Recently, I switched to the generic brand and am still seeing positive results while spending less money.
1Patient Review
9/16/20121Patient Review
11/25/2014 After taking this medication for a few months, my blood pressure started to rise. My numbers would be 158/108. I was also constantly dehydrated and had swollen fingers, ankles, and feet.
Patient Q&A Section about lotrel
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Lotrel a good blood pressure medication?
"Both medications in Lotrel, amlodipine and benazepril, are recommended as first-choice medications to help lower blood pressure. The combination of these two medications lowers blood pressure better than either one by itself."
Answered by AI
What medications should not be taken with Lotrel?
"Some products that may interact with this drug include: aliskiren, certain drugs that weaken the immune system/increase the risk of infection (such as everolimus, sirolimus), lithium, drugs that may increase the level of potassium in the blood (such as ARBs including losartan/valsartan, birth control pills containing drospirenone)."
Answered by AI
Does Lotrel contain a diuretic?
"Lotrel is a combination of Lotensin and Norvasc. The other pill contains Lotensin and a diuretic called hydrochlorothiazide."
Answered by AI
What are the side effects of Lotrel?
"The symptoms of the flu can include coughing, dizziness, lightheadedness, headache, and swelling of the hands/ankles/feet."
Answered by AI