Lotrel

Congestive Heart Failure, Primary Hypercholesterolemia, Coronary Disease + 13 more
Treatment
5 FDA approvals
20 Active Studies for Lotrel

What is Lotrel

AmlodipineThe Generic name of this drug
Treatment SummaryAmlodipine is a medication used to treat high blood pressure and chest pain. It belongs to a class of drugs called dihydropyridine calcium channel blockers, which are known for having fewer side effects than other types of hypertension medications. Amlodipine has antioxidant properties and works by increasing nitric oxide production, which helps to relax and widen the blood vessels, reducing blood pressure. It was approved by the FDA in 1987 and is often prescribed in a single daily dose.
Norvascis the brand name
image of different drug pills on a surface
Lotrel Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Norvasc
Amlodipine
1992
1199

Approved as Treatment by the FDA

Amlodipine, also known as Norvasc, is approved by the FDA for 5 uses like Angina, Stable and Coronary Artery Disease .
Angina, Stable
Used to treat Chronic Stable Angina Pectoris in combination with Atorvastatin
Coronary Artery Disease
Used to treat angiographically documented disease in combination with Atorvastatin
Coronary Artery Disease (CAD)
Used to treat Coronary Artery Disease (CAD) in combination with Atorvastatin
Vasospastic Angina
Used to treat Vasospastic Angina in combination with Atorvastatin
Coronary Disease
Used to treat Coronary Artery Disease (CAD) in combination with Atorvastatin

Effectiveness

How Lotrel Affects PatientsAmlodipine helps reduce blood pressure by blocking certain calcium channels in the body. It is usually taken once daily and its effects last up to 24 hours. Taking this drug does not usually affect heart rate or blood pressure in people with chronic stable angina. Amlodipine also helps relieve chest pain associated with angina by increasing exercise time, decreasing the frequency of angina attacks, and lowering the need for nitroglycerin tablets.
How Lotrel works in the bodyAmlodipine is a type of drug that helps to lower blood pressure and reduce the symptoms of angina. It works by blocking the influx of calcium ions into both cardiac and vascular smooth muscle cells, causing them to relax and widen. This results in a decrease in total peripheral resistance and myocardial oxygen use, as well as an increase in myocardial oxygen delivery in areas with ischemia. Additionally, amlodipine can cause coronary vessels to widen, reducing coronary vasoconstriction.

When to interrupt dosage

The endorsed dosage of Lotrel is contingent upon the diagnosed condition, including inadequate response to diet, High Cardiovascular Risk and Lifestyle Modification. The amount of dosage will vary, depending on the method of administration (e.g. Tablet, film coated or Tablet) detailed in the table below.
Condition
Dosage
Administration
Dyslipidemias
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
High Cardiovascular Risk
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Pharmacotherapy
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Homozygous Familial Hypercholesterolemia
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Vasospastic Angina
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
inadequate response to diet
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Congestive Heart Failure
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Primary Hypercholesterolemia
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Coronary Disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Cardiovascular Events
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Lifestyle Modification
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Hypertensive disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Hypertensive disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Angina, Stable
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Coronary Artery Disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Dyslipidemias
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension

Warnings

Lotrel has one contraindication, so it should not be combined with the circumstances specified in the following table.Lotrel Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Amlodipine may interact with Pulse Frequency
There are 20 known major drug interactions with Lotrel.
Common Lotrel Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Amlodipine may increase the hypotensive activities of Amifostine.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Hydroxyzine.
Mobocertinib
Major
The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Mobocertinib.
Ziprasidone
Major
The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Ziprasidone.
Abafungin
Minor
The therapeutic efficacy of Abafungin can be increased when used in combination with Amlodipine.
Lotrel Toxicity & Overdose RiskThe toxic dose of amlodipine in mice is 37 mg/kg. An overdose may cause a high level of blood vessel widening, a rapid heartbeat, and severe low blood pressure. Animal studies have not found any cancer-causing effects, although the drug has not been tested on pregnant or lactating women. Mothers should not take amlodipine while nursing.

Lotrel Novel Uses: Which Conditions Have a Clinical Trial Featuring Lotrel?

46 active studies are presently evaluating the potential of Lotrel to reduce High Cardiovascular Risk, Vasospastic Angina and Coronary Artery Disease (CAD).
Condition
Clinical Trials
Trial Phases
Congestive Heart Failure
176 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1
Dyslipidemias
1 Actively Recruiting
Phase 2
inadequate response to diet
0 Actively Recruiting
Homozygous Familial Hypercholesterolemia
1 Actively Recruiting
Phase 3
Hypertensive disease
3 Actively Recruiting
Not Applicable
Vasospastic Angina
1 Actively Recruiting
Phase 2, Phase 3
Dyslipidemias
0 Actively Recruiting
Primary Hypercholesterolemia
10 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Coronary Disease
1 Actively Recruiting
Not Applicable
Lifestyle Modification
2 Actively Recruiting
Not Applicable
Angina, Stable
1 Actively Recruiting
Not Applicable
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Coronary Artery Disease
0 Actively Recruiting
High Cardiovascular Risk
1 Actively Recruiting
Phase 2
Cardiovascular Events
4 Actively Recruiting
Not Applicable
Pharmacotherapy
0 Actively Recruiting

Lotrel Reviews: What are patients saying about Lotrel?

5Patient Review
3/12/2013
Lotrel for High Blood Pressure
I take Lotrel 5/20 (reduced from 5/40) in morning and BP is a little higher first in morning. Doc sugested taking it evening/night. Any comment would be appreciated
5Patient Review
7/29/2013
Lotrel for High Blood Pressure
This medication has been great for controlling my blood pressure, but I have noticed some negative effects on my kidney function.
5Patient Review
7/2/2012
Lotrel for High Blood Pressure
5Patient Review
10/29/2012
Lotrel for High Blood Pressure
5Patient Review
1/24/2014
Lotrel for High Blood Pressure
I'm really annoyed with the dry cough that seems to be getting worse.
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about lotrel

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Lotrel a good blood pressure medication?

"Both medications in Lotrel, amlodipine and benazepril, are recommended as first-choice medications to help lower blood pressure. The combination of these two medications lowers blood pressure better than either one by itself."

Answered by AI

What medications should not be taken with Lotrel?

"Some products that may interact with this drug include: aliskiren, certain drugs that weaken the immune system/increase the risk of infection (such as everolimus, sirolimus), lithium, drugs that may increase the level of potassium in the blood (such as ARBs including losartan/valsartan, birth control pills containing drospirenone)."

Answered by AI

Does Lotrel contain a diuretic?

"Lotrel is a combination of Lotensin and Norvasc. The other pill contains Lotensin and a diuretic called hydrochlorothiazide."

Answered by AI

What are the side effects of Lotrel?

"The symptoms of the flu can include coughing, dizziness, lightheadedness, headache, and swelling of the hands/ankles/feet."

Answered by AI

Clinical Trials for Lotrel

Have you considered Lotrel clinical trials? We made a collection of clinical trials featuring Lotrel, we think they might fit your search criteria.
Have you considered Lotrel clinical trials? We made a collection of clinical trials featuring Lotrel, we think they might fit your search criteria.
Have you considered Lotrel clinical trials? We made a collection of clinical trials featuring Lotrel, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top