620 Participants Needed

PF-07328948 for Heart Failure

Recruiting at 4 trial locations
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this study is to learn about the safety and effects of the study medicine (PF-07328948) for the possible treatment of heart failure (HF).

Who Is on the Research Team?

PC

Pfizer CT.gov Call Center

Principal Investigator

Pfizer

Are You a Good Fit for This Trial?

Adults aged 18 or older with heart failure for at least 3 months, showing specific symptoms and physical capabilities. They must have a certain heart function level, body mass index, symptom severity score, and be able to walk more than 75 meters in six minutes.

Inclusion Criteria

Body mass index of 27 kg/m2 or higher
Kansas City Cardiomyopathy Questionnaire-23 Total Symptom Score < 85
I am 18 years old or older.
See 4 more

Exclusion Criteria

I have major surgery planned that will affect my ability to walk.
I have had a heart transplant, am waiting for one, or will use specific heart medications.
I am allergic or have had a bad reaction to SGLT2 inhibitors.
See 1 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive either PF-07328948 or placebo tablets once daily for 36 weeks

36 weeks
10 visits (in-person), 5 visits (phone)

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • PF-07328948
Trial Overview The trial is testing the safety and effects of PF-07328948 on heart failure. Participants will receive either a high, medium, or low dose of the medication or a placebo to compare outcomes.
How Is the Trial Designed?
4Treatment groups
Experimental Treatment
Placebo Group
Group I: ARM 4Experimental Treatment1 Intervention
Group II: ARM 3Experimental Treatment1 Intervention
Group III: ARM 2Experimental Treatment1 Intervention
Group IV: ARM 1Placebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Pfizer

Lead Sponsor

Trials
4,712
Recruited
50,980,000+
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Vaccine Innovations
Top Products
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Albert Bourla

Pfizer

Chief Executive Officer since 2019

PhD in Biotechnology of Reproduction, Aristotle University of Thessaloniki

Patrizia Cavazzoni profile image

Patrizia Cavazzoni

Pfizer

Chief Medical Officer

MD from McGill University

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