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This trial is studying how two drugs affect people with different types of heart failure.
- Diastolic Heart Failure
- Chronic Kidney Disease
Inclusion CriteriaYou will be eligible if you check “Yes” for the criteria below
Study ObjectivesOutcome measures can provide a clearer picture of what you can expect from a treatment.
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Who is running the clinical trial?
- Your heart is working well with an ejection fraction of over 55%.Your heart has difficulty filling with blood, which can be detected by two out of the following: a ratio called average septal-lateral E/e' greater than 15, or tricuspid regurgitation peak velocity greater than 2.8 meters per second.Your kidneys are not functioning normally, which is determined by a blood test called the eGFR. You are taking a type of medication called a loop diuretic for a condition related to your kidneys, and you have been taking it at a stable dose for at least 4 weeks before the study. You will need to continue taking the same dose of medication for the entire duration of the study.An ultrasound test showed that your left atrial volume index is too high, which means your heart may not be working properly.You have been diagnosed with heart failure and have symptoms classified as II-III by the New York Heart Association. You are currently taking medication called loop diuretics to treat it.
- Group 1: HFpEF-CKD with MANP and oral placebo
- Group 2: HFpEF-EI with MANP and oral placebo
- Group 3: HFpEF-CKD with Sacbitril/Valsartan with an injected placebo
- Group 4: HFpEF-EI with Sacbitril/Valsartan with an injected placebo
- Group 5: HFpEF-CKD with an oral and injected placebo
- Group 6: HFpEF-EI with an oral and injected placebo
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Are there any more room for participants in this research project?
"The clinical trial you are inquiring about is not currently recruiting patients. Although this may be the case, it is important to know that there are 567 other trials which are actively seeking participants."
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